GDP-L-fucose synthase
Details
- Name
- GDP-L-fucose synthase
- Synonyms
- 1.1.1.271
- GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase
- Protein FX
- Red cell NADP(H)-binding protein
- SDR4E1
- Short-chain dehydrogenase/reductase family 4E member 1
- Gene Name
- TSTA3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010461|GDP-L-fucose synthase MGEPQGSMRILVTGGSGLVGKAIQKVVADGAGLPGEDWVFVSSKDADLTDTAQTRALFEK VQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHMNDNVLHSAFEVGARKVVSCLSTCIFPD KTTYPIDETMIHNGPPHNSNFGYSYAKRMIDVQNRAYFQQYGCTFTAVIPTNVFGPHDNF NIEDGHVLPGLIHKVHLAKSSGSALTVWGTGNPRRQFIYSLDLAQLFIWVLREYNEVEPI ILSVGEEDEVSIKEAAEAVVEAMDFHGEVTFDTTKSDGQFKKTASNSKLRTYLPDFRFTP FKQAVKETCAWFTDNYEQARK
- Number of residues
- 321
- Molecular Weight
- 35892.46
- Theoretical pI
- 6.59
- GO Classification
- Functionscoenzyme binding / electron carrier activity / GDP-4-dehydro-D-rhamnose reductase activity / GDP-L-fucose synthase activity / isomerase activityProcesses'de novo' GDP-L-fucose biosynthetic process / cytolysis / GDP-mannose metabolic process / leukocyte cell-cell adhesionComponentscytoplasm / extracellular exosome
- General Function
- Isomerase activity
- Specific Function
- Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
- Pfam Domain Function
- Epimerase (PF01370)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0010462|GDP-L-fucose synthase (TSTA3) ATGGGTGAACCCCAGGGATCCATGCGGATTCTAGTGACAGGGGGCTCTGGGCTGGTAGGC AAAGCCATCCAGAAGGTGGTAGCAGATGGAGCTGGACTTCCTGGAGAGGACTGGGTGTTT GTCTCCTCTAAAGACGCCGATCTCACGGATACAGCACAGACCCGCGCCCTGTTTGAGAAG GTCCAACCCACACACGTCATCCATCTTGCTGCAATGGTGGGGGGCCTGTTCCGGAATATC AAATACAATTTGGACTTCTGGAGGAAAAACGTGCACATGAACGACAACGTCCTGCACTCG GCCTTTGAGGTGGGCGCCCGCAAGGTGGTGTCCTGCCTGTCCACCTGTATCTTCCCTGAC AAGACGACCTACCCGATAGATGAGACCATGATCCACAATGGGCCTCCCCACAACAGCAAT TTTGGGTACTCGTATGCCAAGAGGATGATCGACGTGCAGAACAGGGCCTACTTCCAGCAG TACGGCTGCACCTTCACCGCTGTCATCCCCACCAACGTCTTCGGGCCCCACGACAACTTC AACATCGAGGATGGCCACGTGCTGCCTGGCCTCATCCACAAGGTGCACCTGGCCAAGAGC AGCGGCTCGGCCCTGACGGTGTGGGGTACAGGGAATCCGCGGAGGCAGTTCATATACTCG CTGGACCTGGCCCAGCTCTTTATCTGGGTCCTGCGGGAGTACAATGAAGTGGAGCCCATC ATCCTCTCCGTGGGCGAGGAAGATGAGGTCTCCATCAAGGAGGCAGCCGAGGCGGTGGTG GAGGCCATGGACTTCCATGGGGAAGTCACCTTTGATACAACCAAGTCGGATGGGCAGTTT AAGAAGACAGCCAGTAACAGCAAGCTGAGGACCTACCTGCCCGACTTCCGGTTCACACCC TTCAAGCAGGCGGTGAAGGAGACCTGTGCTTGGTTCACTGACAACTACGAGCAGGCCCGG AAGTGA
- Chromosome Location
- 8
- Locus
- 8q24.3
- External Identifiers
Resource Link UniProtKB ID Q13630 UniProtKB Entry Name FCL_HUMAN GenBank Protein ID 1381179 GenBank Gene ID U58766 GenAtlas ID TSTA3 HGNC ID HGNC:12390 - General References
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- Zhou H, Sun L, Li J, Xu C, Yu F, Liu Y, Ji C, He J: The crystal structure of human GDP-L-fucose synthase. Acta Biochim Biophys Sin (Shanghai). 2013 Sep;45(9):720-5. doi: 10.1093/abbs/gmt066. Epub 2013 Jun 16. [Article]