Metabotropic glutamate receptor 2
Details
- Name
- Metabotropic glutamate receptor 2
- Synonyms
- GPRC1B
- MGLUR2
- Gene Name
- GRM2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010682|Metabotropic glutamate receptor 2 MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
- Number of residues
- 872
- Molecular Weight
- 95566.715
- Theoretical pI
- 8.16
- GO Classification
- Functionscalcium channel regulator activity / G-protein coupled receptor activity / glutamate receptor activity / group II metabotropic glutamate receptor activityProcessesG-protein coupled glutamate receptor signaling pathway / glutamate secretion / negative regulation of adenylate cyclase activity / regulation of synaptic transmission, glutamatergic / synaptic transmissionComponentsaxon / cell junction / dendrite / integral component of plasma membrane / intracellular / plasma membrane / presynaptic membrane
- General Function
- Group ii metabotropic glutamate receptor activity
- Specific Function
- G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
- Pfam Domain Function
- Transmembrane Regions
- 568-590 605-625 637-655 680-700 726-747 761-783 794-819
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010683|Metabotropic glutamate receptor 2 (GRM2) ATGGGATCGCTGCTTGCGCTCCTGGCACTGCTGCTGCTGTGGGGTGCTGTGGCTGAGGGC CCAGCCAAGAAGGTGCTGACCCTGGAGGGAGACTTGGTGCTGGGTGGGCTGTTCCCAGTG CACCAGAAGGGCGGCCCAGCAGAGGACTGTGGTCCTGTCAATGAGCACCGTGGCATCCAG CGCCTGGAGGCCATGCTTTTTGCACTGGACCGCATCAACCGTGACCCGCACCTGCTGCCT GGCGTGCGCCTGGGTGCACACATCCTCGACAGTTGCTCCAAGGACACACATGCGCTGGAG CAGGCACTGGACTTTGTGCGTGCCTCACTCAGCCGTGGTGCTGATGGCTCACGCCACATC TGCCCCGACGGCTCTTATGCGACCCATGGTGATGCTCCCACTGCCATCACTGGTGTTATT GGCGGTTCCTACAGTGATGTCTCCATCCAGGTGGCCAACCTCTTGAGGCTATTTCAGATC CCACAGATTAGCTACGCCTCTACCAGTGCCAAGCTGAGTGACAAGTCCCGCTATGACTAC TTTGCCCGCACAGTGCCTCCTGACTTCTTCCAAGCCAAGGCCATGGCTGAGATTCTCCGC TTCTTCAACTGGACCTATGTGTCCACTGTGGCGTCTGAGGGCGACTATGGCGAGACAGGC ATTGAGGCCTTTGAGCTAGAGGCTCGTGCCCGCAACATCTGTGTGGCCACCTCGGAGAAA GTGGGCCGTGCCATGAGCCGCGCGGCCTTTGAGGGTGTGGTGCGAGCCCTGCTGCAGAAG CCCAGTGCCCGCGTGGCTGTCCTGTTCACCCGTTCTGAGGATGCCCGGGAGCTGCTTGCT GCCAGCCAGCGCCTCAATGCCAGCTTCACCTGGGTGGCCAGTGATGGTTGGGGGGCCCTG GAGAGTGTGGTGGCAGGCAGTGAGGGGGCTGCTGAGGGTGCTATCACCATCGAGCTGGCC TCCTACCCCATCAGTGACTTTGCCTCCTACTTCCAGAGCCTGGACCCTTGGAACAACAGC CGGAACCCCTGGTTCCGTGAATTCTGGGAGCAGAGGTTCCGCTGCAGCTTCCGGCAGCGA GACTGCGCAGCCCACTCTCTCCGGGCTGTGCCCTTTGAGCAGGAGTCCAAGATCATGTTT GTGGTCAATGCAGTGTACGCCATGGCCCATGCGCTCCACAACATGCACCGTGCCCTCTGC CCCAACACCACCCGGCTCTGTGACGCGATGCGGCCAGTTAACGGGCGCCGCCTCTACAAG GACTTTGTGCTCAACGTCAAGTTTGATGCCCCCTTTCGCCCAGCTGACACCCACAATGAG GTCCGCTTTGACCGCTTTGGTGATGGTATTGGCCGCTACAACATCTTCACCTATCTGCGT GCAGGCAGTGGGCGCTATCGCTACCAGAAGGTGGGCTACTGGGCAGAAGGCTTGACTCTG GACACCAGCCTCATCCCATGGGCCTCACCCTCAGCCGGCCCCCTGCCCGCCTCTCGCTGC AGTGAGCCCTGCCTCCAGAATGAGGTGAAGAGTGTGCAGCCGGGCGAAGTCTGCTGCTGG CTCTGCATTCCGTGCCAGCCCTATGAGTACCGATTGGACGAATTCACTTGCGCTGATTGT GGCCTGGGCTACTGGCCCAATGCCAGCCTGACTGGCTGCTTCGAACTGCCCCAGGAGTAC ATCCGCTGGGGCGATGCCTGGGCTGTGGGACCTGTCACCATCGCCTGCCTCGGTGCCCTG GCCACCCTCTTTGTGCTGGGTGTCTTTGTGCGGCACAATGCCACACCAGTGGTCAAGGCC TCAGGTCGGGAGCTCTGCTACATCCTGCTGGGTGGTGTCTTCCTCTGCTACTGCATGACC TTCATCTTCATTGCCAAGCCATCCACGGCAGTGTGTACCTTACGGCGTCTTGGTTTGGGC ACTGCCTTCTCTGTCTGCTACTCAGCCCTGCTCACCAAGACCAACCGCATTGCACGCATC TTCGGTGGGGCCCGGGAGGGTGCCCAGCGGCCACGCTTCATCAGTCCTGCCTCACAGGTG GCCATCTGCCTGGCACTTATCTCGGGCCAGCTGCTCATCGTGGTCGCCTGGCTGGTGGTG GAGGCACCGGGCACAGGCAAGGAGACAGCCCCCGAACGGCGGGAGGTGGTGACACTGCGC TGCAACCACCGCGATGCAAGTATGTTGGGCTCGCTGGCCTACAATGTGCTCCTCATCGCG CTCTGCACGCTTTATGCCTTCAAGACTCGCAAGTGCCCCGAAAACTTCAACGAGGCCAAG TTCATTGGCTTCACCATGTACACCACCTGCATCATCTGGCTGGCATTCCTGCCCATCTTC TATGTCACCTCCAGTGACTACCGGGTACAGACCACCACCATGTGCGTGTCAGTCAGCCTC AGCGGCTCCGTGGTGCTTGGCTGCCTCTTTGCGCCCAAGCTGCACATCATCCTCTTCCAG CCGCAGAAGAACGTGGTTAGCCACCGGGCACCCACCAGCCGCTTTGGCAGTGCTGCTGCC AGGGCCAGCTCCAGCCTTGGCCAAGGGTCTGGCTCCCAGTTTGTCCCCACTGTTTGCAAT GGCCGTGAGGTGGTGGACTCGACAACGTCATCGCTTTGA
- Chromosome Location
- 3
- Locus
- 3p21.1
- External Identifiers
Resource Link UniProtKB ID Q14416 UniProtKB Entry Name GRM2_HUMAN GenBank Protein ID 999416 GenBank Gene ID L35318 GenAtlas ID GRM2 HGNC ID HGNC:4594 - General References
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