Caspase-8

Details

Name
Caspase-8
Synonyms
  • 3.4.22.61
  • Apoptotic cysteine protease
  • Apoptotic protease Mch-5
  • CAP4
  • CASP-8
  • FADD-homologous ICE/ced-3-like protease
  • FADD-like ICE
  • FLICE
  • ICE-like apoptotic protease 5
  • MACH
  • MCH5
  • MORT1-associated ced-3 homolog
Gene Name
CASP8
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006731|Caspase-8
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Number of residues
479
Molecular Weight
55390.53
Theoretical pI
4.73
GO Classification
Functions
cysteine-type endopeptidase activity / cysteine-type endopeptidase activity involved in apoptotic process / cysteine-type endopeptidase activity involved in apoptotic signaling pathway / cysteine-type peptidase activity / death effector domain binding / peptidase activity / scaffold protein binding / ubiquitin protein ligase binding
Processes
activation of cysteine-type endopeptidase activity / activation of cysteine-type endopeptidase activity involved in apoptotic process / activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / angiogenesis / apoptotic process / apoptotic signaling pathway / B cell activation / cell surface receptor signaling pathway / cellular component disassembly involved in execution phase of apoptosis / cellular response to mechanical stimulus / cellular response to organic cyclic compound / death-inducing signaling complex assembly / execution phase of apoptosis / extrinsic apoptotic signaling pathway / heart development / hepatocyte apoptotic process / innate immune response / intrinsic apoptotic signaling pathway / macrophage differentiation / MyD88-independent toll-like receptor signaling pathway / natural killer cell activation / necroptotic process / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / negative regulation of I-kappaB kinase/NF-kappaB signaling / negative regulation of necroptotic process / neural tube formation / nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway / nucleotide-binding oligomerization domain containing signaling pathway / positive regulation of extrinsic apoptotic signaling pathway / positive regulation of I-kappaB kinase/NF-kappaB signaling / positive regulation of macrophage differentiation / positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway / positive regulation of proteolysis / programmed cell death / programmed necrotic cell death / protein heterooligomerization / proteolysis / proteolysis involved in cellular protein catabolic process / regulation of extrinsic apoptotic signaling pathway via death domain receptors / regulation of necrotic cell death / regulation of thymocyte apoptotic process / regulation of tumor necrosis factor-mediated signaling pathway / response to antibiotic / response to cobalt ion / response to cold / response to estradiol / response to ethanol / response to lipopolysaccharide / response to tumor necrosis factor / stimulatory C-type lectin receptor signaling pathway / syncytiotrophoblast cell differentiation involved in labyrinthine layer development / T cell activation / toll-like receptor 3 signaling pathway / toll-like receptor 4 signaling pathway / toll-like receptor signaling pathway / TRAIL-activated apoptotic signaling pathway / TRIF-dependent toll-like receptor signaling pathway / tumor necrosis factor-mediated signaling pathway / viral process
Components
CD95 death-inducing signaling complex / cell body / cytoplasm / cytoskeleton / cytosol / death-inducing signaling complex / membrane raft / microtubule organizing center / mitochondrial outer membrane / mitochondrion / neuron projection / Noc1p-Noc2p complex / nucleoplasm / ripoptosome
General Function
Ubiquitin protein ligase binding
Specific Function
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0019424|Caspase-8 (CASP8)
ATGGACTTCAGCAGAAATCTTTATGATATTGGGGAACAACTGGACAGTGAAGATCTGGCC
TCCCTCAAGTTCCTGAGCCTGGACTACATTCCGCAAAGGAAGCAAGAACCCATCAAGGAT
GCCTTGATGTTATTCCAGAGACTCCAGGAAAAGAGAATGTTGGAGGAAAGCAATCTGTCC
TTCCTGAAGGAGCTGCTCTTCCGAATTAATAGACTGGATTTGCTGATTACCTACCTAAAC
ACTAGAAAGGAGGAGATGGAAAGGGAACTTCAGACACCAGGCAGGGCTCAAATTTCTGCC
TACAGGGTCATGCTCTATCAGATTTCAGAAGAAGTGAGCAGATCAGAATTGAGGTCTTTT
AAGTTTCTTTTGCAAGAGGAAATCTCCAAATGCAAACTGGATGATGACATGAACCTGCTG
GATATTTTCATAGAGATGGAGAAGAGGGTCATCCTGGGAGAAGGAAAGTTGGACATCCTG
AAAAGAGTCTGTGCCCAAATCAACAAGAGCCTGCTGAAGATAATCAACGACTATGAAGAA
TTCAGCAAAGGGGAGGAGTTGTGTGGGGTAATGACAATCTCGGACTCTCCAAGAGAACAG
GATAGTGAATCACAGACTTTGGACAAAGTTTACCAAATGAAAAGCAAACCTCGGGGATAC
TGTCTGATCATCAACAATCACAATTTTGCAAAAGCACGGGAGAAAGTGCCCAAACTTCAC
AGCATTAGGGACAGGAATGGAACACACTTGGATGCAGGGGCTTTGACCACGACCTTTGAA
GAGCTTCATTTTGAGATCAAGCCCCACGATGACTGCACAGTAGAGCAAATCTATGAGATT
TTGAAAATCTACCAACTCATGGACCACAGTAACATGGACTGCTTCATCTGCTGTATCCTC
TCCCATGGAGACAAGGGCATCATCTATGGCACTGATGGACAGGAGGCCCCCATCTATGAG
CTGACATCTCAGTTCACTGGTTTGAAGTGCCCTTCCCTTGCTGGAAAACCCAAAGTGTTT
TTTATTCAGGCTTGTCAGGGGGATAACTACCAGAAAGGTATACCTGTTGAGACTGATTCA
GAGGAGCAACCCTATTTAGAAATGGATTTATCATCACCTCAAACGAGATATATCCCGGAT
GAGGCTGACTTTCTGCTGGGGATGGCCACTGTGAATAACTGTGTTTCCTACCGAAACCCT
GCAGAGGGAACCTGGTACATCCAGTCACTTTGCCAGAGCCTGAGAGAGCGATGTCCTCGA
GGCGATGATATTCTCACCATCCTGACTGAAGTGAACTATGAAGTAAGCAACAAGGATGAC
AAGAAAAACATGGGGAAACAGATGCCTCAGCCTACTTTCACACTAAGAAAAAAACTTGTC
TTCCCTTCTGATTGA
Chromosome Location
2
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ14790
UniProtKB Entry NameCASP8_HUMAN
GenBank Gene IDAC007256
GenAtlas IDCASP8
HGNC IDHGNC:1509
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12651BardoxoloneinvestigationalunknownDetails
DB11752Bryostatin 1investigationalunknowninhibitorDetails
DB05103AN-9investigationalyesregulatorDetails
DB04297Trichostatin AexperimentalunknownactivatorDetails
DB12843Oleandrinexperimental, investigationalunknownregulatorDetails