Advanced glycosylation end product-specific receptor

Details

Name
Advanced glycosylation end product-specific receptor
Synonyms
  • RAGE
  • Receptor for advanced glycosylation end products
Gene Name
AGER
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052530|Advanced glycosylation end product-specific receptor
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA
WKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI
PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH
PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL
VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYS
CVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGV
ILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
Number of residues
404
Molecular Weight
42802.385
Theoretical pI
Not Available
GO Classification
Functions
advanced glycation end-product receptor activity / amyloid-beta binding / identical protein binding / protein-containing complex binding / S100 protein binding / scavenger receptor activity / signaling receptor activity / transmembrane signaling receptor activity
Processes
astrocyte activation / cell surface receptor signaling pathway / cellular response to amyloid-beta / glucose mediated signaling pathway / induction of positive chemotaxis / inflammatory response / innate immune response / learning or memory / microglial cell activation / modulation of age-related behavioral decline / negative regulation of blood circulation / negative regulation of connective tissue replacement involved in inflammatory response wound healing / negative regulation of interleukin-10 production / negative regulation of long-term synaptic depression / negative regulation of long-term synaptic potentiation / neuron projection development / positive regulation of activated T cell proliferation / positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / positive regulation of chemokine biosynthetic process / positive regulation of dendritic cell differentiation / positive regulation of endothelin production / positive regulation of ERK1 and ERK2 cascade / positive regulation of heterotypic cell-cell adhesion / positive regulation of interleukin-1 beta production / positive regulation of interleukin-12 production / positive regulation of interleukin-6 production / positive regulation of JNK cascade / positive regulation of JUN kinase activity / positive regulation of monocyte chemotactic protein-1 production / positive regulation of monocyte extravasation / positive regulation of NF-kappaB transcription factor activity / positive regulation of NIK/NF-kappaB signaling / positive regulation of p38MAPK cascade / positive regulation of protein phosphorylation / positive regulation of tumor necrosis factor biosynthetic process / protein localization to membrane / regulation of CD4-positive, alpha-beta T cell activation / regulation of DNA binding / regulation of long-term synaptic potentiation / regulation of NIK/NF-kappaB signaling / regulation of p38MAPK cascade / regulation of spontaneous synaptic transmission / regulation of synaptic plasticity / regulation of T cell mediated cytotoxicity / response to amyloid-beta / response to hypoxia / response to wounding / transcytosis / transport across blood-brain barrier
Components
apical plasma membrane / cell junction / cell surface / extracellular region / fibrillar center / integral component of plasma membrane / plasma membrane / postsynapse
General Function
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Specific Function
Advanced glycation end-product receptor activity
Pfam Domain Function
Transmembrane Regions
343-363
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052531|Advanced glycosylation end product-specific receptor (AGER)
ATGGCTGCCGGAACAGCAGTTGGAGCCTGGGTGCTGGTCCTCAGTCTGTGGGGGGCAGTA
GTAGGTGCTCAAAACATCACAGCCCGGATTGGCGAGCCACTGGTGCTGAAGTGTAAGGGG
GCCCCCAAGAAACCACCCCAGCGGCTGGAATGGAAACTGAACACAGGCCGGACAGAAGCT
TGGAAGGTCCTGTCTCCCCAGGGAGGAGGCCCCTGGGACAGTGTGGCTCGTGTCCTTCCC
AACGGCTCCCTCTTCCTTCCGGCTGTCGGGATCCAGGATGAGGGGATTTTCCGGTGCCAG
GCAATGAACAGGAATGGAAAGGAGACCAAGTCCAACTACCGAGTCCGTGTCTACCAGATT
CCTGGGAAGCCAGAAATTGTAGATTCTGCCTCTGAACTCACGGCTGGTGTTCCCAATAAG
GTGGGGACATGTGTGTCAGAGGGAAGCTACCCTGCAGGGACTCTTAGCTGGCACTTGGAT
GGGAAGCCCCTGGTGCCTAATGAGAAGGGAGTATCTGTGAAGGAACAGACCAGGAGACAC
CCTGAGACAGGGCTCTTCACACTGCAGTCGGAGCTAATGGTGACCCCAGCCCGGGGAGGA
GATCCCCGTCCCACCTTCTCCTGTAGCTTCAGCCCAGGCCTTCCCCGACACCGGGCCTTG
CGCACAGCCCCCATCCAGCCCCGTGTCTGGGAGCCTGTGCCTCTGGAGGAGGTCCAATTG
GTGGTGGAGCCAGAAGGTGGAGCAGTAGCTCCTGGTGGAACCGTAACCCTGACCTGTGAA
GTCCCTGCCCAGCCCTCTCCTCAAATCCACTGGATGAAGGATGGTGTGCCCTTGCCCCTT
CCCCCCAGCCCTGTGCTGATCCTCCCTGAGATAGGGCCTCAGGACCAGGGAACCTACAGC
TGTGTGGCCACCCATTCCAGCCACGGGCCCCAGGAAAGCCGTGCTGTCAGCATCAGCATC
ATCGAACCAGGCGAGGAGGGGCCAACTGCAGGCTCTGTGGGAGGATCAGGGCTGGGAACT
CTAGCCCTGGCCCTGGGGATCCTGGGAGGCCTGGGGACAGCCGCCCTGCTCATTGGGGTC
ATCTTGTGGCAAAGGCGGCAACGCCGAGGAGAGGAGAGGAAGGCCCCAGAAAACCAGGAG
GAAGAGGAGGAGCGTGCAGAACTGAATCAGTCGGAGGAACCTGAGGCAGGCGAGAGTAGT
ACTGGAGGGCCTTGA
Chromosome Location
6
Locus
6p21.32
External Identifiers
ResourceLink
UniProtKB IDQ15109
UniProtKB Entry NameRAGE_HUMAN
HGNC IDHGNC:320
General References
  1. Neeper M, Schmidt AM, Brett J, Yan SD, Wang F, Pan YC, Elliston K, Stern D, Shaw A: Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem. 1992 Jul 25;267(21):14998-5004. [Article]
  2. Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T: Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3. Genomics. 1994 Sep 15;23(2):408-19. [Article]
  3. Yonekura H, Yamamoto Y, Sakurai S, Petrova RG, Abedin MJ, Li H, Yasui K, Takeuchi M, Makita Z, Takasawa S, Okamoto H, Watanabe T, Yamamoto H: Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury. Biochem J. 2003 Mar 15;370(Pt 3):1097-109. doi: 10.1042/BJ20021371. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00107Oxytocinapproved, vet_approvedunknownbinderDetails