Ryanodine receptor 3

Details

Name
Ryanodine receptor 3
Synonyms
  • Brain ryanodine receptor-calcium release channel
  • Brain-type ryanodine receptor
  • HBRR
  • RYR-3
  • Type 3 ryanodine receptor
Gene Name
RYR3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009058|Ryanodine receptor 3
MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP
PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYL
TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER
YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD
QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED
QGLILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS
GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ
FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQNLFKEEG
MLALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN
NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDI
LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW
YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW
SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS
FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGIRDLLGT
TQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR
QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS
NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV
PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVSIDKIRFFRVERSY
AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWHQGSGYFGR
TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGR
MNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVMRID
GTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI
LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE
SVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEPN
TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSEEKNPVPQCPPRLDVQTIQPVLW
SRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYH
TLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASAKE
RKLMMKNEYIIPITSTTRNIRLFPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTGEDHQ
KQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD
DDVRQILLLIDPSVFGEHSAGTEEGAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLP
ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA
RKTKEFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEED
TSWTGKLCALVYKIKGPPKPEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDSELVR
MMFNLLRRQYDSIGELLQALRKTYTISHTSVSDTINLLAALGQIRSLLSVRMGKEEELLM
INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF
CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALSLEEPDLE
KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL
LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVSTGDDEEEEEIVH
MGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLP
SLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLD
TVSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTK
AQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCL
PSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDT
RITATLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKY
GISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRE
NEKLRSVSQANQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG
GSHPLLVPYDTLTAKEKFKDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKF
LKKILKYVDSAQEFIAHLEAIVSSGKTEKSPRDQEIKFFAKVLLPLVDQYFTSHCLYFLS
SPLKPLSSSGYASHKEKEMVAGLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT
VMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPI
LTSIFEHVTQHQFGMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA
AIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAES
GARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILKII
NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADG
KGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFI
LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLY
SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKS
DDPAVKWQLNLYKDVLKSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLS
KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEE
EEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEDEDK
EKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGN
AGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE
RGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQES
ISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV
VGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV
ESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEID
FLLSCAEADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAES
VLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQE
KMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLEPAS
AFAMACASVKRNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLF
TILGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGI
TTELVHFIKGEKGDTDIMSDLFGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLESTVQ
KKRKAQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRCGQK
VEKPEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEE
ETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKV
PLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVIN
KYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDN
SFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV
VYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD
PYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY
FDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDC
FRKQYEDQLG
Number of residues
4870
Molecular Weight
552037.115
Theoretical pI
Not Available
GO Classification
Functions
calcium ion binding / calcium-induced calcium release activity / calcium-release channel activity / ryanodine-sensitive calcium-release channel activity
Processes
calcium ion transmembrane transport / calcium ion transport / cellular response to ATP / cellular response to caffeine / cellular response to calcium ion / cellular response to magnesium ion / ion transmembrane transport / negative regulation of cytosolic calcium ion concentration / protein homotetramerization / striated muscle contraction / transmembrane transport
Components
cytosol / integral component of membrane / junctional membrane complex / perinuclear region of cytoplasm / sarcoplasmic reticulum membrane
General Function
Ryanodine-sensitive calcium-release channel activity
Specific Function
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling.
Pfam Domain Function
Transmembrane Regions
4187-4207 4410-4430 4485-4505 4610-4630 4633-4653 4672-4692 4753-4773
Cellular Location
Sarcoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0021437|Ryanodine receptor 3 (RYR3)
ATGGCCGAAGGGGGAGAAGGAGGCGAGGACGAGATCCAGTTTCTGAGGACTGAGGATGAA
GTGGTACTCCAGTGCATCGCCACCATTCATAAGGAGCAGAGGAAGTTCTGCCTGGCAGCC
GAGGGACTTGGGAATCGCCTGTGCTTCTTGGAACCCACTTCAGAAGCCAAGTACATTCCT
CCAGATCTCTGCGTCTGCAATTTTGTGCTGGAACAGTCCCTATCTGTCAGAGCCCTGCAG
GAAATGCTTGCCAACACAGGTGAAAATGGCGGCGAAGGGGCAGCACAAGGAGGTGGCCAC
AGGACCCTGTTATACGGCCATGCAGTTCTCCTGAGGCACTCTTTCAGCGGAATGTATCTA
ACATGCTTGACTACATCAAGATCCCAGACAGACAAACTTGCCTTTGATGTAGGTCTACGG
GAACATGCCACAGGAGAAGCCTGTTGGTGGACTATACATCCTGCTTCCAAACAGAGGTCC
GAAGGAGAGAAAGTTCGAATTGGCGATGACCTCATCCTCGTCAGCGTGTCCTCTGAAAGA
TACCTTCATCTCTCAGTATCAAATGGTAACATACAAGTGGATGCCTCCTTTATGCAAACA
CTCTGGAATGTACATCCTACGTGCTCAGGAAGTAGCATCGAAGAAGGATACCTACTTGGT
GGGCATGTAGTACGTCTTTTCCATGGTCATGATGAATGTTTGACGATACCATCTACAGAC
CAGAATGATTCCCAGCACAGGAGGATATTCTACGAAGCTGGGGGAGCTGGGACTCGAGCC
AGGTCTCTTTGGAGAGTGGAACCCCTTCGGATAAGCTGGAGTGGCAGTAACATCAGATGG
GGCCAGGCTTTCCGACTCCGGCATCTCACCACAGGCCACTACCTGGCCTTGACAGAAGAC
CAAGGCCTTATACTGCAAGACCGGGCAAAGTCAGACACCAAGTCCACAGCTTTCTCTTTC
CGGGCATCAAAGGAACTCAAGGAGAAATTAGACTCCAGTCACAAGCGAGACATAGAAGGC
ATGGGAGTTCCAGAAATCAAGTATGGAGATTCTGTCTGCTTTGTGCAGCATATAGCCAGT
GGTCTGTGGGTGACCTACAAAGCACAAGACGCCAAAACTTCCCGCCTGGGACCTCTAAAA
AGAAAGGTCATACTCCATCAGGAAGGCCACATGGATGATGGATTAACACTGCAGAGATGC
CAGCGTGAGGAGTCCCAGGCTGCTCGGATCATCCGGAACACTACAGCCTTATTCAGCCAG
TTTGTCAGCGGAAACAATCGCACAGCTGCCCCCATCACCCTGCCTATAGAAGAAGTCCTG
CAGACCCTACAGGACTTGATCGCCTACTTCCAGCCCCCAGAGGAGGAGATGCGACATGAA
GACAAGCAGAACAAGCTCCGCTCACTCAAAAACAGACAAAATCTTTTCAAGGAAGAGGGA
ATGTTGGCCCTTGTCTTAAATTGCATTGACCGCTTAAATGTCTACAATAGCGTAGCACAC
TTTGCAGGGATTGCAAGGGAAGAGAGTGGCATGGCCTGGAAAGAAATTCTGAACCTCCTC
TACAAATTGCTGGCTGCTCTCATTCGCGGAAACAGAAACAATTGCGCTCAATTCTCCAAT
AACCTTGATTGGCTCATCAGTAAATTGGACAGACTAGAATCTTCCTCAGGTATCTTGGAA
GTTTTGCACTGCATCTTAACTGAAAGCCCAGAAGCCTTAAATCTGATAGCGGAGGGCCAC
ATCAAGTCGATCATCTCCCTGTTGGATAAGCACGGGCGGAATCACAAGGTTCTGGATATC
CTGTGCTCCCTCTGTCTCTGCAATGGGGTTGCAGTGAGAGCCAACCAGAATCTGATCTGT
GACAACTTGCTGCCCCGGAGAAACCTACTCCTGCAGACACGACTGATTAACGATGTAACC
AGTATCCGGCCAAACATCTTCCTGGGAGTCGCGGAGGGCTCAGCCCAGTACAAGAAGTGG
TACTTCGAGCTGATTATCGACCAGGTGGACCCCTTCCTAACAGCAGAGCCCACACATCTG
CGGGTGGGCTGGGCCTCTTCTTCAGGCTATGCCCCATACCCAGGAGGTGGAGAAGGATGG
GGAGGCAATGGTGTTGGTGACGACCTGTACTCCTATGGCTTTGATGGACTTCACCTTTGG
TCAGGCCGGATACCCAGAGCTGTGGCTTCCATCAACCAGCACCTCCTGAGATCGGATGAC
GTGGTAAGCTGCTGCCTGGACCTCGGGGTGCCCAGCATCTCATTCCGCATCAATGGGCAG
CCCGTGCAGGGGATGTTTGAGAACTTCAACACAGACGGGCTCTTCTTCCCTGTGATGAGC
TTTTCAGCAGGTGTCAAAGTACGTTTCCTGATGGGTGGACGTCATGGAGAGTTTAAGTTC
CTGCCTCCCTCTGGCTATGCCCCTTGCTATGAAGCCTTACTTCCAAAAGAGAAGATGAGA
TTGGAGCCTGTCAAAGAATATAAACGTGATGCTGATGGCATTAGAGATCTCTTGGGTACC
ACCCAGTTCCTCTCCCAAGCCTCTTTCATCCCATGCCCCGTAGACACCAGTCAGGTTATT
TTGCCACCTCACCTAGAAAAGATCCGAGACAGACTAGCTGAAAACATCCATGAGCTTTGG
GGAATGAATAAAATAGAACTTGGCTGGACTTTCGGCAAGATACGAGATGACAATAAAAGA
CAACACCCTTGCCTTGTGGAGTTTTCAAAGCTCCCAGAAACTGAGAAGAACTATAACCTG
CAAATGTCAACTGAAACCTTAAAAACCCTCTTGGCCCTGGGGTGCCACATTGCTCATGTT
AACCCAGCTGCTGAGGAGGATCTCAAGAAGGTCAAACTGCCCAAAAACTATATGATGTCC
AACGGCTATAAGCCAGCCCCTTTGGATTTGTCTGATGTGAAGCTGTTACCTCCTCAAGAA
ATTTTAGTGGATAAGCTTGCAGAAAATGCACACAATGTTTGGGCAAAAGACAGAATAAAA
CAAGGATGGACCTATGGCATCCAACAGGATTTGAAGAACAAAAGAAATCCCCGTCTGGTG
CCATATGCATTACTGGATGAGCGTACCAAGAAGTCAAACAGGGACAGCCTGCGGGAAGCT
GTGCGCACTTTTGTTGGTTACGGGTATAACATTGAGCCATCAGACCAAGAACTAGCTGAC
TCGGCTGTGGAGAAGGTCAGCATAGACAAGATCCGATTTTTCCGGGTAGAGCGATCTTAT
GCAGTGAGATCTGGAAAGTGGTATTTTGAGTTTGAAGTGGTGACTGGAGGAGACATGCGA
GTCGGCTGGGCGAGGCCAGGCTGTCGACCTGATGTCGAGCTGGGGGCCGATGACCAAGCC
TTTGTGTTTGAAGGCAACAGGGGCCAGCGTTGGCATCAAGGAAGTGGGTATTTTGGGCGT
ACCTGGCAGCCAGGGGATGTGGTCGGATGTATGATTAACCTGGATGATGCTTCAATGATC
TTCACACTGAATGGGGAGCTGCTGATCACCAACAAAGGCTCTGAACTTGCCTTCGCTGAC
TACGAGATTGAGAATGGCTTCGTGCCCATCTGCTGTCTGGGTCTATCTCAGATCGGCCGC
ATGAATCTCGGGACAGATGCCAGTACCTTCAAGTTTTATACCATGTGCGGTCTCCAAGAG
GGCTTTGAGCCTTTTGCTGTCAACATGAACAGAGATGTTGCTATGTGGTTCAGCAAGCGC
CTCCCGACGTTTGTCAACGTGCCAAAGGATCATCCACACATAGAGGTCATGAGGATTGAT
GGCACCATGGACAGCCCTCCGTGTCTCAAGGTGACGCATAAGACATTTGGCACACAGAAT
AGCAATGCCGACATGATCTATTGCCGCTTGAGCATGCCTGTCGAGTGCCACTCCTCCTTC
AGCCACAGCCCCTGTCTGGACAGTGAAGCTTTCCAGAAAAGGAAACAGATGCAAGAAATA
CTCTCTCATACAACAACACAGTGCTACTACGCCATCCGCATCTTTGCTGGACAGGATCCA
TCCTGTGTCTGGGTCGGATGGGTGACTCCAGACTATCACTTGTACAGTGAAAAGTTTGAC
CTGAATAAAAACTGCACAGTGACTGTCACCCTAGGGGATGAAAGAGGCCGGGTCCATGAA
AGTGTGAAACGCAGCAACTGCTACATGGTCTGGGGTGGAGACATTGTAGCCAGTTCCCAG
AGATCAAATCGGAGCAACGTGGACCTGGAGATCGGCTGTCTCGTGGATCTGGCCATGGGC
ATGTTGTCCTTCTCAGCCAATGGAAAGGAACTGGGCACCTGCTACCAGGTGGAGCCTAAT
ACCAAAGTGTTTCCAGCAGTCTTCCTGCAGCCTACAAGTACTTCTTTGTTTCAGTTTGAA
CTTGGAAAGCTGAAGAACGCAATGCCCCTGTCAGCGGCCATATTCAGGAGTGAAGAGAAG
AACCCAGTCCCACAGTGTCCACCTCGGCTGGACGTCCAAACCATCCAGCCCGTGCTCTGG
AGCCGCATGCCCAACAGCTTCCTGAAGGTGGAGACCGAGCGTGTGAGCGAGCGCCACGGC
TGGGTGGTGCAGTGCCTGGAGCCCCTGCAGATGATGGCGCTCCACATCCCCGAGGAGAAC
AGGTGTGTGGATATCCTGGAGCTCTGTGAGCAGGAGGACCTGATGCGGTTCCATTACCAC
ACGCTGAGGCTCTACAGCGCGGTGTGCGCCCTGGGAAACAGCCGCGTGGCCTACGCCCTG
TGCAGCCACGTGGACCTCTCCCAGCTCTTCTATGCCATTGACAACAAGTACCTCCCCGGC
CTCCTTCGATCTGGTTTCTATGACCTGCTCATCAGCATCCACCTGGCCAGCGCCAAGGAG
AGGAAGCTGATGATGAAGAACGAGTACATCATCCCCATTACCAGCACCACCAGGAATATC
CGCCTCTTCCCGGACGAGTCCAAGAGGCATGGACTGCCTGGGGTGGGCCTGAGAACATGT
CTCAAGCCCGGGTTCAGGTTCTCCACCCCTTGCTTTGTTGTGACTGGTGAGGATCACCAA
AAGCAGAGCCCCGAGATTCCCTTGGAGAGTCTCAGGACGAAGGCTCTGAGTATGCTGACA
GAGGCAGTGCAGTGCAGCGGGGCCCACATCCGAGACCCTGTAGGGGGGTCTGTGGAGTTC
CAGTTTGTGCCTGTGCTGAAACTCATTGGAACCCTGCTGGTCATGGGCGTGTTTGATGAT
GATGATGTTCGGCAGATCCTCCTCCTGATTGATCCCTCTGTGTTTGGGGAGCATAGTGCG
GGGACAGAGGAGGGAGCAGAAAAGGAGGAAGTGACCCAGGTGGAGGAGAAGGCTGTGGAG
GCTGGGGAGAAGGCCGGCAAGGAGGCTCCTGTCAAAGGCTTGTTGCAGACTCGATTACCC
GAATCCGTCAAGCTGCAGATGTGTGAGCTCCTCAGCTATCTCTGCGACTGTGAGCTGCAG
CACCGAGTGGAGGCCATTGTGGCATTTGGTGACATTTATGTCTCCAAGCTGCAGGCAAAT
CAGAAGTTCCGCTACAATGAGCTCATGCAGGCCCTGAACATGTCTGCGGCCCTGACTGCC
CGGAAGACCAAGGAGTTCCGCTCACCCCCACAGGAGCAGATCAACATGCTGCTTAACTTT
CAACTGGGAGAGAACTGCCCCTGCCCAGAGGAGATTCGGGAGGAGCTGTATGATTTCCAT
GAGGACCTTCTCCTTCACTGTGGGGTTCCTTTGGAAGAAGAGGAAGAGGAGGAGGAGGAC
ACCTCCTGGACAGGAAAACTCTGTGCCTTGGTTTACAAAATCAAAGGCCCACCCAAGCCA
GAGAAGGAGCAGCCGACGGAGGAGGAGGAGAGATGCCCCACAACATTGAAGGAACTCATC
TCACAGACGATGATCTGCTGGGCCCAGGAGGACCAGATCCAGGATTCAGAGCTGGTCCGA
ATGATGTTCAACCTCCTCCGGAGGCAGTATGACAGCATTGGGGAGCTGCTGCAGGCGCTG
CGGAAGACCTACACCATCAGCCACACCTCTGTAAGCGACACCATCAACCTGCTGGCTGCC
CTGGGCCAAATCCGCTCCCTCCTCAGTGTCAGGATGGGCAAGGAAGAGGAGTTGCTCATG
ATCAATGGGCTGGGAGACATAATGAACAACAAGGTGTTTTACCAGCATCCCAACCTCATG
AGAGTCCTGGGCATGCACGAGACGGTGATGGAGGTGATGGTGAACGTGTTGGGTACAGAG
AAATCTCAGATTGCATTTCCAAAGATGGTTGCTAGCTGCTGCCGTTTCCTTTGCTATTTC
TGTCGAATTAGCCGGCAAAATCAGAAGGCCATGTTTGAGCATCTGAGTTATCTTCTGGAG
AATAGCAGTGTTGGCCTAGCCTCCCCGTCGATGAGGGGATCCACCCCGCTGGATGTGGCA
GCTTCCTCTGTGATGGACAACAATGAGTTAGCGCTGAGCTTAGAGGAACCAGACCTCGAG
AAGGTGGTGACCTACTTGGCAGGCTGTGGCCTACAGAGCTGCCCCATGCTTCTGGCCAAA
GGATACCCTGATGTCGGCTGGAACCCCATTGAAGGGGAACGCTACCTGTCCTTCCTGAGG
TTTGCTGTCTTCGTGAACAGTGAGAGTGTGGAAGAAAACGCCAGCGTTGTGGTCAAGCTG
CTCATCAGACGCCCAGAGTGCTTCGGCCCGGCCCTGCGGGGTGAGGGGGGAAACGGGCTC
TTGGCAGCCATGCAGGGTGCCATTAAGATCTCTGAGAACCCAGCGCTCGACCTCCCCTCT
CAAGGATACAAAAGAGAAGTCAGCACGGGGGACGATGAAGAGGAAGAAGAAATCGTGCAT
ATGGGCAATGCAATTATGTCATTTTATTCGGCCCTTATAGATCTACTGGGCCGCTGTGCT
CCTGAAATGCACCTCATCCAGACAGGAAAGGGGGAAGCCATCCGCATCAGGTCCATCCTG
CGCTCCCTGGTCCCCACAGAAGACCTGGTTGGGATCATCAGCATCCCCTTGAAACTGCCC
TCCCTCAACAAAGATGGGTCGGTCAGTGAGCCAGATATGGCGGCCAATTTCTGCCCTGAC
CACAAGGCACCTATGGTGCTGTTCTTGGACCGCGTTTATGGCATTAAGGATCAAACTTTT
CTGCTCCACTTGCTGGAGGTTGGATTTTTACCTGACCTAAGAGCTTCTGCCTCTCTAGAT
ACAGTTTCCCTAAGCACCACAGAGGCTGCGCTTGCACTAAATAGGTATATATGTTCTGCT
GTGCTCCCGCTCCTCACAAGATGTGCCCCTCTCTTTGCCGGAACAGAACACTGCACCTCT
CTGATTGATTCCACACTGCAGACAATATACAGGCTATCCAAGGGACGTTCCCTCACCAAA
GCACAAAGGGACACTATAGAAGAATGTTTGCTTGCCATTTGCAATCACTTGAGGCCTTCC
ATGTTACAGCAACTCCTGCGACGCCTCGTTTTTGATGTGCCGCAACTCAATGAATACTGC
AAAATGCCTCTCAAGCTTCTGACGAATCACTATGAACAGTGTTGGAAGTATTACTGCCTG
CCTTCAGGATGGGGGAGCTACGGGCTAGCTGTGGAAGAAGAGCTGCACCTAACGGAGAAG
CTTTTCTGGGGGATTTTTGACTCGCTCTCCCATAAGAAATATGACCCAGATCTTTTCCGA
ATGGCCCTGCCTTGTCTCAGTGCTATAGCTGGGGCCTTGCCACCAGATTATTTAGATACC
AGAATCACAGCCACGTTGGAGAAACAGATCTCAGTGGATGCGGATGGCAACTTTGACCCA
AAACCTATTAACACCATGAATTTTTCCTTGCCTGAAAAATTGGAATACATCGTCACCAAG
TATGCTGAGCATTCACATGATAAATGGGCCTGTGACAAGAGTCAGAGTGGATGGAAATAT
GGGATTTCCCTGGATGAAAATGTGAAGACCCACCCACTGATAAGGCCTTTCAAGACATTA
ACGGAGAAGGAGAAGGAAATTTATCGCTGGCCTGCGCGAGAGTCCCTGAAAACCATGCTG
GCTGTGGGCTGGACTGTGGAGAGGACCAAAGAGGGAGAAGCTTTGGTTCAACAGCGGGAA
AATGAGAAGCTTCGAAGTGTGTCCCAGGCCAACCAGGGCAACAGCTACAGTCCTGCTCCC
CTCGACCTCTCAAACGTTGTGCTCTCCAGAGAGCTCCAGGGAATGGTGGAGGTCGTGGCT
GAGAACTATCACAATATCTGGGCCAAGAAGAAGAAGCTGGAGCTGGAGAGCAAAGGTGGT
GGCAGCCACCCTCTTCTGGTACCATATGACACCTTGACTGCCAAGGAAAAGTTCAAGGAC
CGGGAGAAGGCACAGGACCTGTTTAAGTTCCTCCAAGTGAATGGCATCATAGTTTCCAGG
GGTATGAAGGATATGGAGCTGGATGCCTCCTCCATGGAGAAGAGGTTTGCCTATAAGTTC
TTGAAGAAGATCCTGAAATACGTTGATTCTGCTCAAGAATTTATTGCCCATTTAGAAGCC
ATTGTCAGCAGTGGGAAAACTGAAAAGTCTCCCCGTGACCAGGAGATCAAATTCTTTGCC
AAAGTTCTCCTCCCGCTGGTTGACCAGTACTTCACCAGTCATTGCCTCTACTTCTTGTCA
TCCCCTCTGAAGCCCCTTAGCAGCAGCGGATATGCCTCCCATAAGGAGAAAGAAATGGTG
GCCGGCCTGTTCTGCAAACTTGCCGCTCTCGTTAGACACAGAATTTCCCTCTTTGGTAGT
GATTCTACTACAATGGTGAGCTGTCTTCACATCTTAGCTCAGACACTTGACACAAGGACT
GTCATGAAGTCAGGCTCAGAGCTGGTGAAGGCTGGGTTACGAGCATTCTTTGAAAATGCT
GCAGAAGATTTGGAGAAGACTTCAGAAAACCTGAAACTTGGGAAGTTCACCCATTCCCGA
ACGCAGATTAAAGGCGTTTCTCAGAATATTAACTACACTACAGTGGCTCTGCTCCCCATC
CTGACGTCCATCTTTGAGCACGTCACTCAGCATCAGTTTGGAATGGATCTACTCTTGGGT
GATGTGCAGATTTCATGCTACCACATACTGTGCAGCCTCTACTCCCTTGGGACGGGAAAG
AACATTTATGTTGAAAGGCAACGCCCTGCCCTTGGAGAATGTCTGGCCTCGCTGGCAGCT
GCCATACCAGTGGCATTCCTGGAGCCCACCCTTAATCGCTACAATCCACTCTCGGTCTTC
AACACCAAAACCCCCAGGGAGAGGTCTATTCTGGGGATGCCAGACACGGTAGAAGACATG
TGTCCTGACATCCCCCAGCTGGAAGGCCTGATGAAGGAAATCAACGACCTGGCCGAGTCA
GGGGCCCGGTACACAGAGATGCCCCATGTCATCGAGGTGATCTTACCCATGCTCTGCAAC
TACTTGTCCTACTGGTGGGAGCGGGGTCCTGAGAACCTGCCCCCCAGCACAGGGCCATGC
TGCACCAAGGTCACCTCTGAACACCTCAGTCTCATCCTGGGCAACATTCTGAAAATCATC
AACAACAACCTGGGCATCGATGAGGCCTCCTGGATGAAGCGCATTGCAGTGTATGCACAG
CCCATCATCAGCAAAGCCAGGCCCGACCTGCTGAGAAGCCACTTCATCCCAACTCTGGAG
AAGCTGAAGAAAAAGGCTGTCAAGACGGTGCAGGAGGAGGAGCAGTTGAAAGCCGATGGC
AAAGGGGACACCCAGGAGGCAGAACTCCTCATCCTGGACGAGTTCGCGGTCCTCTGCAGA
GATCTCTATGCCTTCTACCCCATGCTGATCCGCTACGTGGACAACAACAGATCTAACTGG
CTGAAAAGTCCTGATGCTGATTCTGACCAGCTCTTCCGCATGGTGGCAGAAGTCTTCATT
CTGTGGTGTAAATCTCATAACTTCAAGAGAGAAGAGCAAAATTTTGTGATTCAGAATGAA
ATTAATAATTTGGCATTTTTAACTGGAGACAGCAAAAGCAAGATGTCAAAAGCCATGCAA
GTAAAGTCTGGAGGACAAGACCAGGAGCGGAAGAAGACAAAGCGGCGGGGAGACTTGTAT
TCCATCCAGACCTCCCTCATCGTGGCTGCACTCAAGAAAATGCTGCCCATTGGTTTGAAT
ATGTGTACTCCAGGCGACCAGGAGCTGATCTCCCTCGCAAAATCGCGATACAGCCATAGG
GACACAGATGAAGAGGTCAGAGAACATCTGCGGAACAACTTGCACTTGCAGGAAAAGTCT
GATGACCCAGCTGTAAAATGGCAACTGAACCTCTACAAGGATGTTCTGAAGAGTGAAGAA
CCTTTCAATCCGGAAAAGACAGTGGAGCGTGTGCAGAGAATTTCAGCAGCTGTCTTCCAC
CTGGAACAGGTGGAACAGCCTTTGAGGTCCAAGAAGGCCGTCTGGCACAAACTGTTATCA
AAGCAACGGAAACGGGCAGTGGTGGCCTGTTTCAGGATGGCCCCTCTCTACAACCTGCCC
AGGCACCGCTCTATTAACCTCTTCCTCCATGGCTATCAGAGATTTTGGATAGAAACAGAG
GAGTATTCCTTTGAAGAGAAACTAGTACAGGATTTGGCTAAATCTCCAAAGGTGGAAGAG
GAGGAGGAGGAAGAGACAGAAAAACAACCTGACCCACTACATCAGATCATTCTCTATTTT
AGCCGCAACGCTCTCACGGAGAGGAGCAAATTGGAAGACGACCCTTTGTACACCTCCTAT
TCCAGCATGATGGCCAAGAGTTGTCAAAGTGGTGAGGATGAAGAAGAAGATGAAGACAAG
GAAAAAACATTCGAAGAGAAAGAGATGGAGAAGCAAAAAACCCTCTATCAGCAAGCTCGG
CTGCATGAGCGTGGTGCTGCAGAGATGGTCCTTCAGATGATAAGCGCTAGCAAAGGTGAG
ATGAGCCCCATGGTGGTTGAGACGCTGAAGCTGGGGATCGCCATTCTGAACGGAGGCAAT
GCTGGTGTGCAACAGAAAATGCTAGATTACCTAAAGGAGAAAAAGGATGCTGGATTCTTT
CAAAGCCTTTCTGGTCTTATGCAGTCTTGCAGTGTCCTTGATTTGAATGCATTTGAGAGG
CAGAATAAAGCTGAAGGCCTGGGGATGGTGACTGAAGAAGGAACACTCATTGTTCGGGAA
CGTGGTGAAAAAGTACTCCAGAATGACGAGTTCACGCGTGATCTCTTTAGATTCCTACAG
TTACTTTGTGAGGGACATAACAGTGACTTTCAGAACTTCCTGCGGACTCAGATGGGCAAC
ACCACCACCGTGAATGTCATCATCAGCACTGTGGACTACCTTCTGCGTCTGCAGGAATCA
ATCAGTGATTTCTACTGGTATTATTCAGGGAAGGACATCATTGATGAATCTGGACAGCAC
AATTTTTCCAAAGCTCTGGCAGTCACCAAGCAGATTTTCAATTCTCTTACAGAATACATC
CAGGGCCCTTGCATTGGTAATCAACAGAGCCTGGCTCACAGCAGGCTGTGGGACGCAGTG
GTTGGCTTCCTCCATGTCTTTGCTAATATGCAGATGAAACTCTCTCAGGATTCCAGTCAG
ATCGAGCTGCTGAAGGAACTCTTGGATCTCCTTCAGGACATGGTGGTGATGCTTCTGTCC
CTCCTGGAAGGGAATGTGGTAAATGGCACCATTGGCAAGCAGATGGTTGACACACTGGTA
GAATCATCTACCAATGTAGAAATGATCTTGAAATTCTTTGACATGTTCTTGAAACTTAAA
GACTTAACCAGCTCAGACACCTTCAAAGAATATGACCCAGATGGTAAAGGAATTATCTCC
AAAAAAGAATTCCAGAAGGCCATGGAAGGGCAAAAACAGTACACGCAGTCAGAGATTGAC
TTTCTCCTGTCGTGTGCAGAAGCTGATGAGAATGACATGTTTAATTACGTTGATTTTGTA
GACCGGTTCCATGAGCCAGCCAAGGACATAGGGTTTAATGTGGCTGTGTTATTGACAAAT
CTTTCTGAACACATGCCAAACGATTCCCGCCTGAAGTGTCTGTTGGACCCAGCAGAAAGT
GTGCTAAATTACTTCGAACCCTACCTAGGACGCATCGAGATCATGGGTGGGGCCAAGAAG
ATTGAGCGTGTTTATTTTGAGATCAGTGAATCCAGTCGCACTCAGTGGGAGAAGCCCCAG
GTGAAGGAATCTAAGCGACAGTTCATTTTTGATGTTGTCAATGAAGGTGGGGAGCAGGAA
AAGATGGAGCTGTTTGTGAACTTCTGTGAGGACACCATCTTTGAAATGCAGTTAGCATCT
CAGATCTCTGAATCCGATTCAGCTGACAGGCCAGAAGAGGAGGAAGAAGATGAAGATTCT
TCTTACGTGTTAGAAATTGCGGGTGAAGAGGAAGAAGACGGGTCTCTTGAGCCGGCCTCT
GCATTTGCTATGGCCTGTGCCTCTGTGAAGAGGAATGTCACCGACTTCCTGAAGAGAGCA
ACCCTGAAGAACCTCAGGAAGCAGTACAGGAACGTGAAAAAGATGACTGCGAAGGAGCTG
GTGAAGGTGCTCTTCTCCTTTTTCTGGATGCTGTTCGTGGGGCTATTCCAGTTGCTCTTC
ACCATCCTGGGAGGAATCTTTCAGATCCTCTGGAGCACAGTGTTTGGAGGGGGCCTGGTA
GAAGGGGCAAAGAACATCAGAGTGACCAAGATCCTGGGTGACATGCCTGACCCAACCCAA
TTTGGTATCCATGATGACACTATGGAGGCTGAGAGGGCAGAGGTGATGGAGCCAGGTATC
ACCACTGAACTAGTACACTTCATAAAGGGGGAGAAGGGAGATACAGATATCATGTCAGAC
CTCTTTGGACTCCACCCAAAGAAAGAGGGCAGCTTAAAGCATGGGCCTGAAGTGGGTTTG
GGTGACCTCTCAGAAATTATTGGCAAGGATGAACCCCCTACATTAGAGAGTACTGTACAG
AAGAAGAGGAAAGCTCAGGCAGCAGAAATGAAAGCAGCAAATGAAGCAGAAGGAAAAGTA
GAATCCGAGAAGGCAGACATGGAAGATGGAGAGAAGGAAGACAAAGACAAAGAAGAGGAG
CAAGCTGAGTACCTGTGGACAGAAGTGACAAAAAAGAAGAAGCGGCGGTGTGGTCAGAAG
GTTGAGAAGCCGGAAGCTTTCACAGCCAATTTCTTTAAAGGGCTGGAAATCTATCAGACC
AAGTTACTGCATTACCTGGCCAGGAATTTCTACAACCTGAGGTTCCTTGCTCTGTTTGTA
GCCTTCGCTATCAACTTCATCCTGCTTTTTTATAAGGTCACTGAAGAACCTTTAGAAGAA
GAGACAGAGGATGTTGCAAACCTATGGAATTCCTTTAATGACGAGGAAGAGGAAGAAGCG
ATGGTATTCTTTGTCCTTCAGGAGAGCACCGGGTATATGGCACCAACCCTGCGTGCCCTG
GCCATCATCCATACCATCATCTCTCTAGTCTGTGTGGTGGGCTACTACTGCCTGAAGGTG
CCTTTGGTGGTTTTCAAAAGGGAAAAAGAAATCGCCAGGAAGCTGGAGTTTGATGGCCTA
TATATCACCGAACAGCCATCTGAAGATGACATCAAGGGGCAGTGGGACCGCTTGGTGATC
AACACACCATCTTTTCCTAATAACTACTGGGACAAGTTTGTAAAGAGAAAGGTGATCAAC
AAGTATGGAGATCTCTACGGAGCAGAACGCATTGCTGAACTTCTGGGTTTGGACAAAAAT
GCTCTTGACTTTAGCCCAGTAGAAGAGACCAAAGCAGAAGCGGCTTCTCTGGTGTCATGG
CTAAGTTCCATAGACATGAAGTACCATATCTGGAAGCTTGGAGTTGTTTTTACTGACAAC
TCCTTTCTCTACCTTGCCTGGTATACAACCATGTCAGTCCTGGGCCACTACAATAACTTC
TTCTTTGCTGCTCACCTATTGGACATCGCAATGGGCTTCAAGACACTGAGGACCATTCTG
TCATCTGTAACTCACAATGGCAAACAGTTGGTTCTGACTGTCGGTCTCCTGGCCGTGGTG
GTTTATCTCTATACTGTGGTGGCTTTCAACTTCTTCCGCAAGTTCTACAACAAAAGCGAA
GACGATGACGAGCCCGATATGAAGTGCGACGACATGATGACGTGTTACCTTTTCCACATG
TACGTGGGAGTGAGAGCAGGAGGTGGCATTGGTGATGAAATTGAAGACCCTGCTGGTGAT
CCTTATGAAATGTATCGCATTGTCTTTGACATTACCTTTTTCTTCTTCGTCATTGTCATC
TTGCTGGCCATCATTCAAGGTCTTATTATTGATGCTTTCGGAGAGCTAAGAGACCAGCAG
GAACAAGTACGAGAAGATATGGAGACTAAATGTTTCATCTGTGGGATTGGCAATGACTAC
TTTGACACAACCCCTCATGGTTTTGAAACACATACATTACAAGAGCACAACTTAGCCAAC
TACTTGTTCTTTCTGATGTATTTGATTAATAAAGATGAAACAGAGCACACGGGTCAGGAA
TCTTATGTCTGGAAGATGTACCAAGAAAGGTGTTGGGATTTCTTCCCAGCCGGTGACTGC
TTTCGTAAACAATATGAAGATCAGCTTGGATAA
Chromosome Location
15
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ15413
UniProtKB Entry NameRYR3_HUMAN
HGNC IDHGNC:10485
General References
  1. Nakashima Y, Nishimura S, Maeda A, Barsoumian EL, Hakamata Y, Nakai J, Allen PD, Imoto K, Kita T: Molecular cloning and characterization of a human brain ryanodine receptor. FEBS Lett. 1997 Nov 3;417(1):157-62. [Article]
  2. Leeb T, Brenig B: cDNA cloning and sequencing of the human ryanodine receptor type 3 (RYR3) reveals a novel alternative splice site in the RYR3 gene. FEBS Lett. 1998 Feb 27;423(3):367-70. [Article]
  3. Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. [Article]
  4. Martin C, Chapman KE, Seckl JR, Ashley RH: Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum. Neuroscience. 1998 Jul;85(1):205-16. [Article]
  5. Hakamata Y, Nishimura S, Nakai J, Nakashima Y, Kita T, Imoto K: Involvement of the brain type of ryanodine receptor in T-cell proliferation. FEBS Lett. 1994 Sep 26;352(2):206-10. [Article]
  6. Sorrentino V, Giannini G, Malzac P, Mattei MG: Localization of a novel ryanodine receptor gene (RYR3) to human chromosome 15q14-q15 by in situ hybridization. Genomics. 1993 Oct;18(1):163-5. [Article]
  7. Lynn S, Morgan JM, Lamb HK, Meissner G, Gillespie JI: Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle. FEBS Lett. 1995 Sep 18;372(1):6-12. [Article]
  8. Schwarzmann N, Kunerth S, Weber K, Mayr GW, Guse AH: Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the T cell receptor/CD3 complex. J Biol Chem. 2002 Dec 27;277(52):50636-42. Epub 2002 Sep 26. [Article]
  9. Wen H, Kang S, Song Y, Song Y, Yang HJ, Kim MH, Park S: Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels. Arch Biochem Biophys. 2012 Jan 1;517(1):37-42. doi: 10.1016/j.abb.2011.11.004. Epub 2011 Nov 11. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11093Calcium citrateapproved, investigationalunknownsubstrateDetails
DB11348Calcium PhosphateapprovedunknownsubstrateDetails
DB14481Calcium phosphate dihydrateapprovedunknownDetails