Mediator of RNA polymerase II transcription subunit 1

Details

Name
Mediator of RNA polymerase II transcription subunit 1
Synonyms
  • Activator-recruited cofactor 205 kDa component
  • ARC205
  • CRSP1
  • CRSP200
  • DRIP205
  • DRIP230
  • Mediator complex subunit 1
  • p53 regulatory protein RB18A
  • PBP
  • Peroxisome proliferator-activated receptor-binding protein
  • PPAR-binding protein
  • PPARBP
  • PPARGBP
  • RB18A
  • Thyroid hormone receptor-associated protein complex 220 kDa component
  • Thyroid receptor-interacting protein 2
  • TR-interacting protein 2
  • TRAP220
  • TRIP-2
  • TRIP2
  • Vitamin D receptor-interacting protein complex component DRIP205
Gene Name
MED1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0008320|Mediator of RNA polymerase II transcription subunit 1
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVS
CLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQL
CDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPI
ILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLP
ACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTL
IGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLY
KGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNL
PPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQ
NPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTL
YGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQ
NPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVT
DILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPAD
LIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFAS
QALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTT
GDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGK
SPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSH
SQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGS
SQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPG
GSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTP
PSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPG
GEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSE
SKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGST
PKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKH
KKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRL
SPDFMIGEEDDDLMDVALIGN
Number of residues
1581
Molecular Weight
168476.57
Theoretical pI
9.1
GO Classification
Functions
chromatin binding / chromatin DNA binding / core promoter binding / estrogen receptor binding / LBD domain binding / ligand-dependent nuclear receptor binding / ligand-dependent nuclear receptor transcription coactivator activity / mediator complex binding / nuclear hormone receptor binding / peroxisome proliferator activated receptor binding / receptor activity / retinoic acid receptor binding / RNA polymerase II core promoter proximal region sequence-specific DNA binding / RNA polymerase II transcription cofactor activity / RNA polymerase II transcription factor activity, sequence-specific DNA binding / thyroid hormone receptor binding / thyroid hormone receptor coactivator activity / transcription coactivator activity / transcription cofactor activity / transcription factor binding / ubiquitin protein ligase activity / vitamin D receptor binding
Processes
androgen biosynthetic process / androgen receptor signaling pathway / angiogenesis / brain development / cell morphogenesis / cellular lipid metabolic process / cellular response to epidermal growth factor stimulus / cellular response to hepatocyte growth factor stimulus / cellular response to steroid hormone stimulus / cellular response to thyroid hormone stimulus / embryonic heart tube development / embryonic hemopoiesis / embryonic hindlimb morphogenesis / embryonic placenta development / enucleate erythrocyte development / epithelial cell proliferation involved in mammary gland duct elongation / ERK1 and ERK2 cascade / erythrocyte development / fat cell differentiation / gene expression / intracellular steroid hormone receptor signaling pathway / keratinocyte differentiation / lactation / lens development in camera-type eye / liver development / mammary gland branching involved in pregnancy / mammary gland branching involved in thelarche / megakaryocyte development / monocyte differentiation / mRNA transcription from RNA polymerase II promoter / negative regulation of apoptotic process / negative regulation of keratinocyte proliferation / negative regulation of neuron differentiation / negative regulation of transcription from RNA polymerase II promoter / organ regeneration / peroxisome proliferator activated receptor signaling pathway / positive regulation of erythrocyte differentiation / positive regulation of G0 to G1 transition / positive regulation of gene expression / positive regulation of hepatocyte proliferation / positive regulation of interferon-gamma-mediated signaling pathway / positive regulation of intracellular estrogen receptor signaling pathway / positive regulation of keratinocyte differentiation / positive regulation of mammary gland epithelial cell proliferation / positive regulation of protein import into nucleus, translocation / positive regulation of receptor activity / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / regulation of cell cycle / regulation of RNA biosynthetic process / regulation of transcription from RNA polymerase I promoter / regulation of vitamin D receptor signaling pathway / retinal pigment epithelium development / small molecule metabolic process / thyroid hormone generation / thyroid hormone mediated signaling pathway / transcription initiation from RNA polymerase II promoter / ventricular trabecula myocardium morphogenesis
Components
chromatin / mediator complex / membrane / nucleolus / nucleoplasm / nucleus / protein-DNA complex / ubiquitin ligase complex
General Function
Vitamin d receptor binding
Specific Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0013052|Mediator of RNA polymerase II transcription subunit 1 (MED1)
ATGAAAGCTCAGGGGGAAACCGAGGAGTCAGAAAAGCTGAGTAAGATGAGTTCTCTCCTG
GAACGGCTCCATGCAAAATTTAACCAAAATAGACCCTGGAGTGAAACCATTAAGCTTGTG
CGTCAAGTCATGGAGAAGAGGGTTGTGATGAGTTCTGGAGGGCATCAACATTTGGTCAGC
TGTTTGGAGACATTGCAGAAGGCTCTCAAAGTAACATCTTTACCAGCAATGACTGATCGT
TTGGAGTCCATAGCAAGACAGAATGGACTGGGCTCTCATCTCAGTGCCAGTGGCACTGAA
TGTTACATCACGTCAGATATGTTCTATGTGGAAGTGCAGTTAGATCCTGCAGGACAGCTT
TGTGATGTAAAAGTGGCTCACCATGGGGAGAATCCTGTGAGCTGTCCGGAGCTTGTACAG
CAGCTAAGGGAAAAAAATTTTGATGAATTTTCTAAGCACCTTAAGGGCCTTGTTAATCTG
TATAACCTTCCAGGGGACAACAAACTGAAGACTAAAATGTACTTGGCTCTCCAATCCTTA
GAACAAGATCTTTCTAAAATGGCAATTATGTACTGGAAAGCAACTAATGCTGGTCCCTTG
GATAAGATTCTTCATGGAAGTGTTGGCTATCTCACACCAAGGAGTGGGGGTCATTTAATG
AACCTGAAGTACTATGTCTCTCCTTCTGACCTACTGGATGACAAGACTGCATCTCCCATC
ATTTTGCATGAGAATAATGTTTCTCGATCTTTGGGCATGAATGCATCAGTGACAATTGAA
GGAACATCTGCTGTGTACAAACTCCCAATTGCACCATTAATTATGGGGTCACATCCAGTT
GACAATAAATGGACCCCTTCCTTCTCCTCAATCACCAGTGCCAACAGTGTTGATCTTCCT
GCCTGTTTCTTCTTGAAATTTCCCCAGCCAATCCCAGTATCTAGAGCATTTGTTCAGAAA
CTGCAGAACTGCACAGGAATTCCATTGTTTGAAACTCAACCAACTTATGCACCCCTGTAT
GAACTGATCACTCAGTTTGAGCTATCAAAGGACCCTGACCCCATACCTTTGAATCACAAC
ATGAGATTTTATGCTGCTCTTCCTGGTCAGCAGCACTGCTATTTCCTCAACAAGGATGCT
CCTCTTCCAGATGGCCGAAGTCTACAGGGAACCCTTGTTAGCAAAATCACCTTTCAGCAC
CCTGGCCGAGTTCCTCTTATCCTAAATCTGATCAGACACCAAGTGGCCTATAACACCCTC
ATTGGAAGCTGTGTCAAAAGAACTATTCTGAAAGAAGATTCTCCTGGGCTTCTCCAATTT
GAAGTGTGTCCTCTCTCAGAGTCTCGTTTCAGCGTATCTTTTCAGCACCCTGTGAATGAC
TCCCTGGTGTGTGTGGTAATGGATGTGCAGGACTCAACACATGTGAGCTGTAAACTCTAC
AAAGGGCTGTCGGATGCACTGATCTGCACAGATGACTTCATTGCCAAAGTTGTTCAAAGA
TGTATGTCCATCCCTGTGACGATGAGGGCTATTCGGAGGAAAGCTGAAACCATTCAAGCC
GACACCCCAGCACTGTCCCTCATTGCAGAGACAGTTGAAGACATGGTGAAAAAGAACCTG
CCCCCGGCTAGCAGCCCAGGGTATGGCATGACCACAGGCAACAACCCAATGAGTGGTACC
ACTACACCAACCAACACCTTTCCGGGGGGTCCCATTACCACCTTGTTTAATATGAGCATG
AGCATCAAAGATCGGCATGAGTCGGTGGGCCATGGGGAGGACTTCAGCAAGGTGTCTCAG
AACCCAATTCTTACCAGTTTGTTGCAAATCACAGGGAACGGGGGGTCTACCATTGGCTCG
AGTCCGACCCCTCCTCATCACACGCCGCCACCTGTCTCTTCGATGGCCGGCAACACCAAG
AACCACCCGATGCTCATGAACCTTCTTAAAGATAATCCTGCCCAGGATTTCTCAACCCTT
TATGGAAGCAGCCCTTTAGAAAGGCAGAACTCCTCTTCCGGCTCACCCCGCATGGAAATA
TGCTCGGGGAGCAACAAGACCAAGAAAAAGAAGTCATCAAGATTACCACCTGAGAAACCA
AAGCACCAGACTGAAGATGACTTTCAGAGGGAGCTATTTTCAATGGATGTTGACTCACAG
AACCCTATCTTTGATGTCAACATGACAGCTGACACGCTGGATACGCCACACATCACTCCA
GCTCCAAGCCAGTGTAGCACTCCCCCAACAACTTACCCACAACCAGTACCTCACCCCCAA
CCCAGTATTCAAAGGATGGTCCGACTATCCAGTTCAGACAGCATTGGCCCAGATGTAACT
GACATCCTTTCAGACATTGCAGAAGAAGCTTCTAAACTTCCCAGCACTAGTGATGATTGC
CCAGCCATTGGCACCCCTCTTCGAGATTCTTCAAGCTCTGGGCATTCTCAGAGTACCCTG
TTTGACTCTGATGTCTTTCAAACTAACAATAATGAAAATCCATACACTGATCCAGCTGAT
CTTATTGCAGATGCTGCTGGAAGCCCCAGTAGTGACTCTCCTACCAATCATTTTTTTCAT
GATGGAGTAGATTTCAATCCTGATTTATTGAACAGCCAGAGCCAAAGTGGTTTTGGAGAA
GAATATTTTGATGAAAGCAGCCAAAGTGGGGATAATGATGATTTCAAAGGATTTGCATCT
CAGGCACTAAATACTTTGGGGGTGCCAATGCTTGGAGGTGATAATGGGGAGACCAAGTTT
AAGGGCAATAACCAAGCCGACACAGTTGATTTCAGTATTATTTCAGTAGCCGGCAAAGCT
TTAGCTCCTGCAGATCTTATGGAGCATCACAGTGGTAGTCAGGGTCCTTTACTGACCACT
GGGGACTTAGGGAAAGAAAAGACTCAAAAGAGGGTAAAGGAAGGCAATGGCACCAGTAAT
AGTACTCTCTCGGGGCCCGGATTAGACAGCAAACCAGGGAAGCGCAGTCGGACCCCTTCT
AATGATGGGAAAAGCAAAGATAAGCCTCCAAAGCGGAAGAAGGCAGACACTGAGGGAAAG
TCTCCATCTCATAGTTCTTCTAACAGACCTTTTACCCCACCTACCAGTACAGGTGGATCT
AAATCGCCAGGCAGTGCAGGAAGATCTCAGACTCCCCCAGGTGTTGCCACACCACCCATT
CCCAAAATCACTATTCAGATTCCTAAGGGAACAGTGATGGTGGGCAAGCCTTCCTCTCAC
AGTCAGTATACCAGCAGTGGTTCTGTGTCTTCCTCAGGCAGCAAAAGCCACCATAGCCAT
TCTTCCTCCTCTTCCTCATCTGCTTCCACCTCAGGGAAGATGAAAAGCAGTAAATCAGAA
GGTTCATCAAGTTCCAAGTTAAGTAGCAGTATGTATTCTAGCCAGGGGTCTTCTGGATCT
AGCCAGTCCAAAAATTCATCCCAGTCTGGGGGGAAGCCAGGCTCCTCTCCCATAACCAAG
CATGGACTGAGCAGTGGCTCTAGCAGCACCAAGATGAAACCTCAAGGAAAGCCATCATCA
CTTATGAATCCTTCTTTAAGTAAACCAAACATATCCCCTTCTCATTCAAGGCCACCTGGA
GGCTCTGACAAGCTTGCCTCTCCAATGAAGCCTGTTCCTGGAACTCCTCCATCCTCTAAA
GCCAAGTCCCCTATCAGTTCAGGTTCTGGTGGTTCTCATATGTCTGGAACTAGTTCAAGC
TCTGGCATGAAGTCATCTTCAGGGTTAGGATCCTCAGGCTCGTTGTCCCAGAAAACTCCC
CCATCATCTAATTCCTGTACGGCATCTTCCTCCTCCTTTTCCTCAAGTGGCTCTTCCATG
TCATCCTCTCAGAACCAGCATGGGAGTTCTAAAGGAAAATCTCCCAGCAGAAACAAGAAG
CCGTCCTTGACAGCTGTCATAGATAAACTGAAGCATGGGGTTGTCACCAGTGGCCCTGGG
GGTGAAGACCCACTGGACGGCCAGATGGGGGTGAGCACAAATTCTTCCAGCCATCCTATG
TCCTCCAAACATAACATGTCAGGAGGAGAGTTTCAGGGCAAGCGTGAGAAAAGTGATAAA
GACAAATCAAAGGTTTCCACCTCCGGGAGTTCAGTGGATTCTTCTAAGAAGACCTCAGAG
TCAAAAAATGTGGGGAGCACAGGTGTGGCAAAAATTATCATCAGTAAGCATGATGGAGGC
TCCCCTAGCATTAAAGCCAAAGTGACTTTGCAGAAACCTGGGGAAAGTAGTGGAGAAGGG
CTTAGGCCTCAAATGGCTTCTTCTAAAAACTATGGCTCTCCACTCATCAGTGGTTCCACT
CCAAAGCATGAGCGTGGCTCTCCCAGCCATAGTAAGTCACCAGCATATACCCCCCAGAAT
CTGGACAGTGAAAGTGAGTCAGGCTCCTCCATAGCAGAGAAATCTTATCAGAATAGTCCC
AGCTCAGACGATGGTATCCGACCACTTCCAGAATACAGCACAGAGAAACATAAGAAGCAC
AAAAAGGAAAAGAAGAAAGTAAAAGACAAAGATAGGGACCGAGACCGGGACAAAGACCGA
GACAAGAAAAAATCTCATAGCATCAAGCCAGAGAGTTGGTCCAAATCACCCATCTCTTCA
GACCAGTCCTTGTCTATGACAAGTAACACAATCTTATCTGCAGACAGACCCTCAAGGCTC
AGCCCAGACTTTATGATTGGGGAGGAAGATGATGATCTTATGGATGTGGCCCTGATTGGG
AATTAG
Chromosome Location
17
Locus
17q12-q21.1
External Identifiers
ResourceLink
UniProtKB IDQ15648
UniProtKB Entry NameMED1_HUMAN
GenBank Protein ID2765322
GenBank Gene IDY13467
HGNC IDHGNC:9234
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04891BecocalcidiolinvestigationalunknownDetails