Cathepsin L-like proteinase

Details

Name

Cathepsin L-like proteinase

Synonyms

• 3.4.22.-

Gene Name

Cat-1

Organism

Fasciola hepatica

Amino acid sequence

>lcl|BSEQ0052094|Cathepsin L-like proteinase
MRLFILAVLTVGVLGSNDDLWHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDL
GLVTYTLGLNQFTDMTFEEFKAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYV
TEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENA
YQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAA
VAVDVESDFMMYRSGIYQSQTCSPLRVNHAVLAVGYGTQGGTDYWIVKNSWGTYWGERGY
IRMARNRGNMCGIASLASLPMVARFP

Number of residues

326

Molecular Weight

36896.305

Theoretical pI

Not Available

GO Classification

Functions

cysteine-type endopeptidase activity / endopeptidase activity

Processes

proteolysis

Components

extracellular region

General Function

Thiol protease. Probably involved in interaction with host tissues. Displays a similar activity to that of papain. Has high activity on Z-Phe-Arg-NHMec, but no activity on Z-Arg-NHMec.

Specific Function

Cysteine-type endopeptidase activity

Pfam Domain Function

• Peptidase_C1 (PF00112)
• Inhibitor_I29 (PF08246)

Transmembrane Regions

Not Available

Cellular Location

Secreted

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q24940
UniProtKB Entry Name	CATLL_FASHE

General References

1. Wijffels GL, Panaccio M, Salvatore L, Wilson L, Walker ID, Spithill TW: The secreted cathepsin L-like proteinases of the trematode, Fasciola hepatica, contain 3-hydroxyproline residues. Biochem J. 1994 May 1;299 ( Pt 3):781-90. doi: 10.1042/bj2990781. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB12245	Triclabendazole	approved, investigational	unknown	inhibitor	Details