Acetylcholine receptor subunit beta-type lev-1

Details

Name
Acetylcholine receptor subunit beta-type lev-1
Synonyms
  • Levamisole-resistant protein 1
Gene Name
lev-1
Organism
Caenorhabditis elegans
Amino acid sequence
>lcl|BSEQ0017564|Acetylcholine receptor subunit beta-type lev-1
MMLGGGGGCGAGGTWLGFLVFLAVSLRNHSTCEDIDAEDRLMVDLFRGYNSLVQPVRNRS
ELPMIVKIGMQLVLLINVDEKEQVMHTNVWLTMKWDDFQLKWDPRDYANITQIRVAPEKV
WLPDIVLFNNADGNYEVSFMCNVLILSTGTVLWVPPAIYKSSCIIDVEFFPFDDQLCSLT
FGSWTYNRDEIKLDFLTSDRVDFSEYSTSSIWDMMDGPAVLTSDRSRIEFQIRIRRKTLF
YTVVLILPTVLMAFLNVTVFYLPTASGEKMGLTMNVLLSIVVFLLLVSKILPPTSSSIPL
VAKYLLLTFVLNIITIMVTTIICNIYFRSPITHRLPPWVRKVFLDILPLLMCMQRPHRKN
VIQRSHRRLLETGPSVEENPMRSGEHHPLCRHTHNQDSCRRVRIQSDELDDELSPEAQRA
IDAIEFITENRRDEEITKQFRDDWKFIASVVDRFLLYGFFGATVGGTIGIIFTAPSVFET
FDENATLVKLKQLYDMGLANDTVLGIF
Number of residues
507
Molecular Weight
58025.88
Theoretical pI
Not Available
GO Classification
Functions
acetylcholine-activated cation-selective channel activity
Processes
cation transmembrane transport / inorganic cation transmembrane transport / neurological system process / neuromuscular synaptic transmission / regulation of locomotion / regulation of membrane potential / regulation of oviposition / response to nicotine / signal transduction / synaptic transmission, cholinergic
Components
acetylcholine-gated channel complex / cell junction / neuron projection / neuronal cell body / postsynaptic membrane
General Function
Acetylcholine-activated cation-selective channel activity
Specific Function
Acetylcholine receptor.
Pfam Domain Function
Transmembrane Regions
139-159 243-263 271-291 305-325 454-474
Cellular Location
Cell junction
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ27218
UniProtKB Entry NameACH7_CAEEL
General References
  1. Fleming JT, Squire MD, Barnes TM, Tornoe C, Matsuda K, Ahnn J, Fire A, Sulston JE, Barnard EA, Sattelle DB, Lewis JA: Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits. J Neurosci. 1997 Aug 1;17(15):5843-57. [Article]
  2. Authors unspecified: Genome sequence of the nematode C. elegans: a platform for investigating biology. Science. 1998 Dec 11;282(5396):2012-8. [Article]
  3. Kaji H, Kamiie J, Kawakami H, Kido K, Yamauchi Y, Shinkawa T, Taoka M, Takahashi N, Isobe T: Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins. Mol Cell Proteomics. 2007 Dec;6(12):2100-9. Epub 2007 Aug 30. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00848Levamisoleapproved, investigational, vet_approved, withdrawnunknownactivatorDetails