Hyaluronidase-4
Details
- Name
- Hyaluronidase-4
- Synonyms
- 3.2.1.35
- Chondroitin sulfate endo-beta-N-acetylgalactosaminidase
- Chondroitin sulfate hydrolase
- CSHY
- Hyal-4
- Hyaluronoglucosaminidase-4
- Gene Name
- HYAL4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052549|Hyaluronidase-4 MKVLSEGQLKLCVVQPVHLTSWLLIFFILKSISCLKPARLPIYQRKPFIAAWNAPTDQCL IKYNLRLNLKMFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTSQGVPINGGLPQNISLQV HLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARNWNSKDVYRQKSRKLISDMGKNVSA TDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGLWGYYLYPDCHNYNVYAPNYSGSCPED EVLRNNELSWLWNSSAALYPSIGVWKSLGDSENILRFSKFRVHESMRISTMTSHDYALPV FVYTRLGYRDEPLFFLSKQDLVSTIGESAALGAAGIVIWGDMNLTASKANCTKVKQFVSS DLGSYIANVTRAAEVCSLHLCRNNGRCIRKMWNAPSYLHLNPASYHIEASEDGEFTVKGK ASDTDLAVMADTFSCHCYQGYEGADCREIKTADGCSGVSPSPGSLMTLCLLLLASYRSIQ L
- Number of residues
- 481
- Molecular Weight
- 54248.74
- Theoretical pI
- Not Available
- GO Classification
- Functionshyalurononglucosaminidase activityProcessescarbohydrate metabolic process / chondroitin sulfate catabolic process / glycosaminoglycan catabolic processComponentscell surface / integral component of membrane
- General Function
- Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.
- Specific Function
- Hyalurononglucosaminidase activity
- Pfam Domain Function
- Glyco_hydro_56 (PF01630)
- Transmembrane Regions
- 9-29 454-474
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0052550|Hyaluronidase-4 (HYAL4) ATGAAAGTATTATCTGAAGGACAGTTAAAGCTTTGTGTTGTTCAACCAGTACATCTCACT TCATGGCTCCTTATATTTTTTATTCTAAAGTCTATCTCTTGTCTAAAACCTGCTCGACTT CCAATTTATCAAAGGAAACCTTTTATAGCTGCTTGGAATGCTCCAACAGATCAGTGTTTG ATAAAATATAATTTAAGACTAAATTTGAAAATGTTTCCTGTGATTGGAAGCCCACTGGCC AAGGCCAGGGGGCAAAATGTCACTATATTTTATGTCAACAGATTGGGATACTATCCGTGG TATACATCACAAGGGGTCCCCATTAATGGAGGTCTCCCACAGAACATAAGTTTACAAGTA CATCTGGAAAAAGCTGACCAAGATATTAATTATTACATCCCTGCTGAAGATTTCAGTGGA CTTGCTGTTATAGATTGGGAATATTGGCGACCACAGTGGGCCCGGAACTGGAACTCAAAA GATGTTTACAGACAGAAGTCAAGAAAGCTTATTTCCGATATGGGAAAGAATGTATCAGCT ACCGATATTGAATATTTAGCCAAAGTGACCTTTGAAGAAAGTGCAAAAGCTTTCATGAAG GAAACCATCAAATTGGGAATTAAGAGCCGACCCAAAGGCCTTTGGGGTTATTATTTATAT CCTGATTGCCACAATTATAACGTTTATGCCCCAAACTACTCTGGGTCATGCCCAGAAGAC GAAGTCTTGAGGAACAATGAGCTCTCTTGGCTCTGGAACAGCAGTGCTGCTTTATATCCT TCTATCGGTGTCTGGAAATCCCTTGGAGACAGTGAAAACATTTTGCGCTTCTCCAAATTT CGGGTGCATGAATCCATGAGGATCTCCACCATGACATCTCATGATTATGCTCTGCCTGTA TTTGTCTACACAAGGCTAGGGTACAGAGATGAACCTTTATTTTTCCTTTCTAAGCAAGAT CTAGTCAGCACCATAGGAGAAAGTGCTGCCTTGGGAGCTGCAGGCATTGTTATTTGGGGA GACATGAATTTAACTGCATCCAAGGCCAACTGTACAAAGGTGAAGCAGTTTGTGAGTTCT GATTTAGGGAGCTACATAGCCAATGTGACCAGAGCTGCTGAGGTATGCAGCCTTCACCTC TGCAGGAACAATGGCAGGTGCATAAGGAAGATGTGGAACGCGCCCAGTTACCTTCACTTG AACCCTGCAAGTTACCACATAGAGGCCTCTGAGGACGGGGAGTTTACTGTGAAAGGAAAA GCATCTGATACAGACCTGGCAGTGATGGCAGATACATTTTCCTGTCATTGTTATCAGGGA TATGAAGGAGCTGATTGCAGAGAAATAAAGACGGCTGATGGCTGCTCTGGGGTTTCCCCT TCTCCTGGTTCACTAATGACACTTTGTCTACTGCTTTTAGCAAGTTATCGAAGCATTCAG TTGTGA
- Chromosome Location
- 7
- Locus
- 7q31.32
- External Identifiers
Resource Link UniProtKB ID Q2M3T9 UniProtKB Entry Name HYAL4_HUMAN HGNC ID HGNC:5323 - General References
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