Electroneutral sodium bicarbonate exchanger 1
Details
- Name
- Electroneutral sodium bicarbonate exchanger 1
- Synonyms
- Electroneutral Na(+)-driven Cl-HCO3 exchanger
- k-NBC3
- KIAA0739
- NBC
- NBC3
- NDCBE1
- Solute carrier family 4 member 8
- Gene Name
- SLC4A8
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009597|Electroneutral sodium bicarbonate exchanger 1 MPAAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQS HRHHRTHGQKHRRRGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTEL DEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGTVLL DMHANSIEEISDLILDQQELSSDLNDSMRVKVREALLKKHHHQNEKKRNNLIPIVRSFAE VGKKQSDPHLMDKHGQTVSPQSVPTTNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEA SNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSM ATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRK MPGVPNGNVCHIEQEPHGGHSGPELQRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLA SFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGP VLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASL ICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTLPENPNNHTLQYWKDHNIVTA EVHWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFTTFILSSTLKTFKTSRY FPTRVRSMVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPW WTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGL PWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAILK FIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLIQL TCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDAK KKAKEEEEAEKMLEIGGDKFPLESRKLLSSPGKNISCRCDPSEINISDEMPKTTVWKALS MNSGNAKEKSLFN
- Number of residues
- 1093
- Molecular Weight
- 122936.66
- Theoretical pI
- Not Available
- GO Classification
- Functionsinorganic anion exchanger activity / sodiumProcessesanion transmembrane transport / bicarbonate transport / ion transport / regulation of intracellular pH / sodium ion transmembrane transport / transmembrane transportComponentsintegral component of plasma membrane / neuron projection / neuronal cell body membrane / plasma membrane
- General Function
- Sodium:bicarbonate symporter activity
- Specific Function
- Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.
- Pfam Domain Function
- Transmembrane Regions
- 479-499 524-544 566-586 596-616 688-708 732-752 779-799 825-845 882-902 905-925 963-983
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0019610|Electroneutral sodium bicarbonate exchanger 1 (SLC4A8) ATGCCGGCCGCCGGGAGTAACGAGCCGGACGGCGTCCTCAGCTATCAGAGACCAGATGAA GAAGCTGTGGTGGATCAGGGTGGGACCAGTACAATTCTCAACATTCACTATGAAAAAGAA GAGCTGGAAGGTCACAGAACTCTGTATGTGGGAGTTCGGATGCCGCTTGGCCGGCAGAGC CATCGGCATCACCGCACTCATGGCCAGAAGCACCGGAGACGAGGGCGGGGCAAAGGAGCC AGCCAGGGGGAGGAAGGCCTGGAAGCCCTGGCCCACGACACACCATCTCAGCGTGTTCAG TTCATTCTTGGCACCGAGGAAGATGAAGAGCATGTGCCTCATGAGCTGTTTACAGAGCTG GATGAGATCTGTATGAAAGAGGGAGAAGATGCTGAGTGGAAGGAAACAGCCAGGTGGCTG AAGTTTGAAGAAGATGTTGAAGATGGGGGAGAACGCTGGAGCAAGCCTTATGTGGCAACC CTTTCATTGCACAGCCTGTTTGAGCTAAGGAGCTGCCTTATTAATGGAACAGTCCTCCTG GATATGCATGCAAATAGCATAGAAGAAATTTCAGACCTGATCCTGGATCAGCAAGAACTG TCCAGTGACCTGAATGACAGCATGAGGGTTAAAGTGCGGGAAGCCCTTCTCAAAAAGCAT CATCATCAGAATGAAAAGAAGAGAAACAACCTCATTCCCATTGTTCGCTCCTTTGCTGAG GTTGGCAAGAAGCAGTCTGATCCTCATTTGATGGATAAACATGGTCAAACCGTGTCTCCT CAGTCTGTTCCAACTACAAATCTTGAAGTAAAAAATGGAGTGAATTGTGAACATAGTCCT GTGGATTTAAGCAAGGTAGACCTTCATTTCATGAAAAAAATTCCTACTGGGGCCGAGGCC TCCAATGTCCTGGTTGGAGAGGTGGATATTTTGGACCGTCCCATTGTTGCCTTTGTGAGG CTGTCTCCAGCTGTTCTTCTCTCAGGCCTAACAGAAGTGCCAATCCCAACAAGATTTTTG TTTATCTTATTGGGTCCAGTAGGGAAAGGTCAGCAGTACCATGAGATTGGCAGATCCATG GCCACCATCATGACAGATGAGATTTTTCATGACGTAGCATATAAGGCAAAAGAGCGAGAT GATCTCCTGGCGGGGATTGATGAGTTCCTAGACCAGGTGACGGTGCTCCCTCCAGGAGAG TGGGATCCCTCCATTAGAATTGAGCCACCCAAAAATGTCCCTTCCCAGGAGAAAAGGAAA ATGCCTGGAGTTCCAAATGGAAATGTTTGCCACATAGAACAGGAACCACATGGGGGTCAC AGTGGGCCAGAACTTCAGCGCACTGGGCGGCTATTTGGGGGCTTGGTGCTGGACATCAAG CGGAAGGCCCCCTGGTACTGGAGCGACTACCGAGATGCACTCAGCTTACAGTGTTTGGCT TCCTTTCTGTTCCTGTACTGTGCCTGCATGTCACCTGTCATCACCTTTGGGGGACTGCTT GGAGAAGCCACTGAGGGACGCATAAGTGCAATTGAATCCTTGTTTGGAGCTTCCATGACT GGGATTGCTTATTCCTTGTTTGCGGGACAGGCTCTCACCATCCTGGGAAGTACTGGACCA GTGCTTGTGTTTGAAAAGATTTTGTTCAAATTCTGCAAAGACTATGCTCTTTCATACCTC TCCCTGCGAGCTTGTATTGGACTGTGGACCGCTTTCCTGTGTATTGTCCTTGTGGCAACT GATGCCAGTTCCCTTGTCTGCTACATTACCCGTTTCACTGAAGAAGCATTTGCCTCCCTA ATTTGCATTATTTTCATCTATGAAGCAATAGAAAAACTGATTCACCTGGCAGAGACCTAC CCCATCCACATGCACAGCCAGCTGGACCACCTTAGCCTCTATTACTGCAGGTGTACTCTG CCAGAGAATCCAAACAATCACACCCTCCAGTACTGGAAGGACCACAACATCGTGACAGCA GAAGTCCACTGGGCTAACCTGACTGTCAGTGAATGCCAGGAGATGCATGGAGAGTTCATG GGATCTGCGTGCGGCCATCATGGACCCTACACTCCTGATGTCCTCTTTTGGTCCTGTATT CTCTTTTTCACCACCTTCATCCTCTCAAGCACCTTAAAGACGTTTAAGACGAGCCGTTAT TTCCCAACCAGAGTACGCTCCATGGTGAGTGACTTTGCTGTTTTCCTCACTATCTTCACA ATGGTGATTATTGATTTTTTGATTGGAGTCCCATCACCAAAGCTTCAAGTTCCCAGTGTG TTCAAGCCAACAAGGGATGATCGCGGATGGATTATTAATCCCATTGGCCCCAATCCCTGG TGGACTGTGATAGCTGCAATTATCCCAGCTCTTCTCTGTACTATCTTGATATTCATGGAT CAGCAGATCACAGCCGTCATTATTAACAGGAAGGAACATAAGCTCAAGAAAGGCTGTGGC TACCACCTGGACCTACTGATGGTGGCCATCATGCTGGGTGTCTGCTCCATCATGGGCCTG CCCTGGTTTGTAGCTGCAACTGTCTTGTCCATCACACATGTGAACAGCCTCAAGCTAGAA TCTGAATGCTCTGCTCCTGGAGAACAGCCCAAGTTCCTGGGCATCCGAGAACAGAGAGTG ACAGGCCTTATGATCTTTGTGCTGATGGGCTGCTCAGTCTTCATGACGGCTATCTTAAAG TTTATTCCAATGCCAGTACTCTACGGAGTTTTCCTTTACATGGGAGTTTCTTCACTACAG GGAATTCAGTTCTTTGATCGTCTAAAGCTCTTTGGGATGCCCGCAAAGCACCAGCCAGAT TTCATCTACCTGCGGCATGTGCCGCTGCGCAAAGTGCACCTCTTCACCCTCATCCAGTTG ACCTGTCTCGTCCTGCTCTGGGTCATCAAGGCATCTCCAGCTGCCATTGTTTTCCCAATG ATGGTTTTGGCCTTGGTCTTTGTCAGGAAAGTCATGGATCTCTGTTTCTCTAAGCGAGAG CTGAGCTGGCTAGATGATCTCATGCCTGAAAGCAAAAAGAAGAAGTTGGATGATGCCAAA AAGAAGGCCAAGGAGGAAGAGGAGGCTGAGAAAATGTTAGAAATTGGGGGAGACAAGTTT CCCTTAGAGAGCAGGAAGTTACTAAGTAGTCCTGGAAAGAACATCAGTTGCAGATGTGAC CCCTCTGAGATTAATATATCTGATGAAATGCCTAAAACTACAGTTTGGAAAGCTCTCAGT ATGAATTCTGGAAATGCAAAGGAAAAGAGTCTCTTCAACTAA
- Chromosome Location
- 12
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q2Y0W8 UniProtKB Entry Name S4A8_HUMAN HGNC ID HGNC:11034 - General References
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