Protein mono-ADP-ribosyltransferase PARP15

Details

Synonyms

2.4.2.-
ADP-ribosyltransferase diphtheria toxin-like 7
ARTD7
B-aggressive lymphoma protein 3
BAL3
PARP-15
Poly [ADP-ribose] polymerase 15

Gene Name

PARP15

UniProtKB Entry

Q460N3Swiss-Prot

Organism

Humans

NCBI Taxonomy ID

9606

Amino acid sequence

>lcl|BSEQ0037277|Protein mono-ADP-ribosyltransferase PARP15
MAAPGPLPAAALSPGAPTPRELMHGVAGVTSRAGRDREAGSVLPAGNRGARKASRRSSSR
SMSRDNKFSKKDCLSIRNVVASIQTKEGLNLKLISGDVLYIWADVIVNSVPMNLQLGGGP
LSRAFLQKAGPMLQKELDDRRRETEEKVGNIFMTSGCNLDCKAVLHAVAPYWNNGAETSW
QIMANIIKKCLTTVEVLSFSSITFPMIGTGSLQFPKAVFAKLILSEVFEYSSSTRPITSP
LQEVHFLVYTNDDEGCQAFLDEFTNWSRINPNKARIPMAGDTQGVVGTVSKPCFTAYEMK
IGAITFQVATGDIATEQVDVIVNSTARTFNRKSGVSRAILEGAGQAVESECAVLAAQPHR
DFIITPGGCLKCKIIIHVPGGKDVRKTVTSVLEECEQRKYTSVSLPAIGTGNAGKNPITV
ADNIIDAIVDFSSQHSTPSLKTVKVVIFQPELLNIFYDSMKKRDLSASLNFQSTFSMTTC
NLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVK
KRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSA
KDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLF
VVFFDNQAYPEYLITFTA

Number of residues

678

Molecular Weight

74575.465

Theoretical pI

9.06

GO Classification

Functions

NAD+ binding / NAD+-protein ADP-ribosyltransferase activity / nucleotidyltransferase activity / transcription corepressor activity

Processes

negative regulation of gene expression / negative regulation of transcription by RNA polymerase II / protein poly-ADP-ribosylation

Components

cytoplasm

General Function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:16061477, PubMed:25043379, PubMed:25635049). Acts as a negative regulator of transcription (PubMed:16061477)

Specific Function

Nad+ adp-ribosyltransferase activity

Pfam Domain Function

PARP (PF00644)
Macro (PF01661)

Signal Regions

Not Available

Transmembrane Regions

Not Available

Cellular Location

Nucleus

Gene sequence

>lcl|BSEQ0019552|Poly [ADP-ribose] polymerase 15 (PARP15)
ATGGCTGCGCCAGGCCCCCTTCCTGCCGCTGCTCTGAGTCCAGGGGCTCCGACCCCCAGA
GAACTTATGCACGGAGTTGCAGGTGTTACTTCCAGAGCCGGACGAGATCGGGAGGCGGGG
AGCGTGCTGCCGGCCGGGAACCGTGGGGCGCGGAAGGCCTCCCGGCGCTCTTCCTCCCGG
AGTATGTCCAGAGACAACAAGTTCAGCAAGAAAGATTGTCTTTCAATCAGGAATGTTGTA
GCTTCAATCCAAACCAAAGAAGGTCTGAATCTCAAGTTGATAAGTGGAGATGTTCTGTAC
ATCTGGGCCGATGTCATTGTCAACAGCGTTCCCATGAATCTTCAGCTTGGAGGAGGACCA
CTATCTCGGGCATTTTTGCAGAAAGCTGGTCCCATGCTCCAGAAAGAGTTAGATGACAGA
AGGCGGGAAACAGAGGAAAAAGTAGGTAACATATTCATGACAAGCGGCTGCAATCTGGAC
TGCAAAGCTGTGCTCCATGCTGTGGCTCCATACTGGAATAATGGAGCAGAGACTTCTTGG
CAGATCATGGCAAATATAATCAAGAAATGTTTGACAACTGTAGAAGTGCTATCTTTCTCA
TCAATCACATTTCCCATGATTGGAACAGGAAGTTTGCAGTTTCCCAAAGCTGTTTTTGCT
AAACTAATCCTTTCAGAAGTGTTCGAATACAGTAGCAGCACAAGGCCGATAACTAGCCCT
TTACAAGAAGTCCACTTTCTGGTATATACAAATGACGATGAAGGCTGTCAGGCATTTTTA
GATGAATTCACTAACTGGTCAAGAATAAATCCCAACAAGGCCAGGATTCCCATGGCAGGA
GATACCCAAGGTGTGGTCGGGACTGTCTCTAAGCCTTGTTTCACAGCATATGAAATGAAA
ATCGGTGCAATTACTTTTCAGGTTGCTACTGGAGATATAGCCACTGAACAGGTAGATGTT
ATTGTAAACTCAACAGCAAGGACATTTAATCGGAAATCAGGTGTGTCAAGAGCTATTTTA
GAAGGTGCTGGACAAGCTGTGGAAAGTGAATGTGCTGTACTAGCTGCACAGCCTCACAGA
GATTTTATAATTACACCAGGTGGATGCTTAAAGTGCAAAATAATAATTCATGTTCCTGGG
GGAAAAGATGTCAGGAAAACGGTCACCAGTGTTCTAGAAGAGTGTGAACAGAGGAAGTAC
ACATCGGTTTCCCTTCCAGCCATTGGAACAGGAAATGCCGGAAAAAACCCTATCACAGTT
GCTGATAACATAATCGATGCTATTGTAGACTTCTCATCACAACATTCCACCCCATCATTA
AAAACAGTTAAAGTTGTCATTTTTCAACCTGAGCTGCTAAATATATTCTACGACAGCATG
AAAAAAAGAGACCTCTCTGCATCACTGAACTTTCAGTCCACATTCTCCATGACTACATGT
AATCTTCCTGAACACTGGACTGACATGAATCATCAGCTGTTTTGCATGGTCCAGCTAGAG
CCAGGACAATCAGAATATAATACCATAAAGGACAAGTTCACCCGAACTTGTTCTTCCTAC
GCAATAGAGAAGATTGAGAGGATACAGAATGCATTTCTCTGGCAGAGCTACCAGGTAAAG
AAAAGGCAAATGGATATCAAGAATGACCATAAGAATAATGAGAGACTCCTCTTCCATGGG
ACAGATGCAGACTCAGTGCCATATGTCAATCAGCACGGCTTTAATAGAAGTTGTGCTGGG
AAAAATGCTGTATCCTATGGAAAAGGAACCTATTTTGCTGTGGATGCCAGTTATTCTGCC
AAGGACACCTACTCCAAGCCAGACAGCAATGGGAGAAAGCACATGTACGTTGTGCGAGTA
CTTACTGGAGTCTTCACAAAGGGACGTGCAGGATTAGTCACCCCTCCACCCAAGAATCCT
CACAATCCCACAGATCTCTTTGACTCAGTGACAAACAATACACGATCTCCAAAGCTATTT
GTGGTATTCTTTGATAATCAGGCTTACCCAGAATATCTCATAACTTTCACGGCTTAA

Chromosome Location

Locus

3q21.1

External Identifiers

Resource	Link
UniProtKB ID	Q460N3
UniProtKB Entry Name	PAR15_HUMAN
GenBank Protein ID	67078854
GenBank Gene ID	DQ063586
GeneCard ID	PARP15
HGNC ID	HGNC:26876
PDB ID(s)	3BLJ, 3GEY, 3V2B, 4F0E, 6EK3, 6RY4, 7F41, 7F42, 7F43, 7OQQ, 7OSP, 7OSS, 7OSX, 7OTF, 7OTH, 7OUW, 7OUX, 7PW3, 7PWA, 7PWC, 7PWK, 7PWL, 7PWM, 7PWP, 7PWQ, 7PWR, 7PWS, 7PWU, 7PWW, 7PX6, 7PX7, 7R3O, 7R4A, 7R5D, 7Z1V, 7Z1W, 7Z1Y, 7Z2O, 7Z2Q, 7Z41
KEGG ID	hsa:165631
IUPHAR/Guide To Pharmacology ID	3270
NCBI Gene ID	165631

General References

Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8. [Article]
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
Aguiar RC, Takeyama K, He C, Kreinbrink K, Shipp MA: B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. J Biol Chem. 2005 Oct 7;280(40):33756-65. Epub 2005 Aug 1. [Article]
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Associated Data

Bio-Entities

Bio-Entity	Type
Protein mono-ADP-ribosyltransferase PARP15 (Humans)	protein primary
Poly [ADP-ribose] polymerases (Humans)	protein

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE	experimental	unknown	target		Details