Beta-lactamase Toho-1
Details
- Name
- Beta-lactamase Toho-1
- Synonyms
- 3.5.2.6
- Gene Name
- bla
- UniProtKB Entry
- Q47066Swiss-Prot
- Organism
- Escherichia coli
- NCBI Taxonomy ID
- 562
- Amino acid sequence
>lcl|BSEQ0021979|Beta-lactamase Toho-1 MMTQSIRRSMLTVMATLPLLFSSATLHAQANSVQQQLEALEKSSGGRLGVALINTADNSQ ILYRADERFAMCSTSKVMAAAAVLKQSESDKHLLNQRVEIKKSDLVNYNPIAEKHVNGTM TLAELGAAALQYSDNTAMNKLIAHLGGPDKVTAFARSLGDETFRLDRTEPTLNTAIPGDP RDTTTPLAMAQTLKNLTLGKALAETQRAQLVTWLKGNTTGSASIRAGLPKSWVVGDKTGS GDYGTTNDIAVIWPENHAPLVLVTYFTQPEQKAERRRDILAAAAKIVTHGF
- Number of residues
- 291
- Molecular Weight
- 31446.6
- Theoretical pI
- 9.6
- GO Classification
- Functionsbeta-lactamase activityProcessesbeta-lactam antibiotic catabolic process / response to antibiotic
- General Function
- Beta-lactamase activity
- Specific Function
- Has strong cefotaxime-hydrolyzing activity.
- Pfam Domain Function
- Beta-lactamase (PF00144)
- Signal Regions
- 1-29
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0003479|876 bp ATGATGACTCAGAGCATTCGCCGCTCAATGTTAACGGTGATGGCGACGCTACCCCTGCTA TTTAGCAGCGCAACGCTGCATGCGCAGGCGAACAGCGTGCAACAGCAGCTGGAAGCCCTG GAGAAAAGTTCGGGAGGTCGGCTTGGCGTTGCGCTGATTAACACCGCCGATAATTCGCAG ATTCTCTACCGTGCCGATGAACGTTTTGCGATGTGCAGTACCAGTAAGGTGATGGCGGCC GCGGCGGTGCTTAAACAGAGCGAGAGCGATAAGCACCTGCTAAATCAGCGCGTTGAAATC AAGAAGAGCGACCTGGTTAACTACAATCCCATTGCGGAGAAACACGTTAACGGCACGATG ACGCTGGCTGAGCTTGGCGCAGCGGCGCTGCAGTATAGCGACAATACTGCCATGAATAAG CTGATTGCCCATCTGGGTGGTCCCGATAAAGTGACGGCGTTTGCTCGCTCGTTGGGTGAT GAGACCTTCCGTCTGGACAGAACCGAGCCCACGCTCAATACCGCCATTCCAGGCGACCCG CGTGATACCACCACGCCGCTCGCGATGGCGCAGACCCTGAAAAATCTGACGCTGGGTAAA GCGCTGGCGGAAACTCAGCGGGCACAGTTGGTGACGTGGCTTAAGGGCAATACTACCGGT AGCGCGAGCATTCGGGCGGGTCTGCCGAAATCATGGGTAGTGGGCGATAAAACCGGCAGC GGAGATTATGGCACCACCAACGATATCGCGGTTATCTGGCCGGAAAACCACGCACCGCTG GTTCTGGTGACCTACTTTACCCAACCGGAGCAGAAGGCGGAAAGGCGTCGGGATATTCTG GCTGCGGCGGCGAAAATCGTAACCCACGGTTTCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q47066 UniProtKB Entry Name BLT1_ECOLX GenBank Protein ID 1037162 GenBank Gene ID D37830 PDB ID(s) 1BZA, 1IYO, 1IYP, 1IYQ, 1IYS, 1WE4, 2WYX, 2XQZ, 2XR0, 2ZQ7, 2ZQ8, 2ZQ9, 2ZQA, 2ZQC, 2ZQD, 4BD0, 4BD1, 4C3Q, 4X69 KEGG ID ag:BAA07082 - General References
- Ishii Y, Ohno A, Taguchi H, Imajo S, Ishiguro M, Matsuzawa H: Cloning and sequence of the gene encoding a cefotaxime-hydrolyzing class A beta-lactamase isolated from Escherichia coli. Antimicrob Agents Chemother. 1995 Oct;39(10):2269-75. [Article]
- Ibuka A, Taguchi A, Ishiguro M, Fushinobu S, Ishii Y, Kamitori S, Okuyama K, Yamaguchi K, Konno M, Matsuzawa H: Crystal structure of the E166A mutant of extended-spectrum beta-lactamase Toho-1 at 1.8 A resolution. J Mol Biol. 1999 Feb 5;285(5):2079-87. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Beta-lactamase Toho-1 (Escherichia coli) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Cephalothin Group experimental unknown target Details (2R)-2-[(1R)-1-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-2-oxoethyl]-5-methylidene-2H-1,3-thiazine-4-carboxylic acid experimental unknown target Details Carbenicillin approved, investigational unknown target substrate Details Oxacillin approved, investigational unknown target substrate Details Ceftazidime approved unknown target substrate Details Aztreonam approved unknown target substrate Details Threonine approved, nutraceutical unknown target unknown Details