Outer membrane protein OprM

Details

Name
Outer membrane protein OprM
Synonyms
  • oprK
Gene Name
oprM
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Amino acid sequence
>lcl|BSEQ0052195|Outer membrane protein OprM
MKRSFLSLAVAAVVLSGCSLIPDYQRPEAPVAAAYPQGQAYGQNTGAAAVPAADIGWREF
FRDPQLQQLIGVALENNRDLRVAALNVEAFRAQYRIQRADLFPRIGVDGSGTRQRLPGDL
STTGSPAISSQYGVTLGTTAWELDLFGRLRSLRDQALEQYLATEQAQRSAQTTLVASVAT
AYLTLKADQAQLQLTKDTLGTYQKSFDLTQRSYDVGVASALDLRQAQTAVEGARATLAQY
TRLVAQDQNALVLLLGSGIPANLPQGLGLDQTLLTEVPAGLPSDLLQRRPDILEAEHQLM
AANASIGAARAAFFPSISLTANAGTMSRQLSGLFDAGSGSWLFQPSINLPIFTAGSLRAS
LDYAKIQKDINVAQYEKAIQTAFQEVADGLAARGTFTEQLQAQRDLVKASDEYYQLADKR
YRTGVDNYLTLLDAQRSLFTAQQQLITDRLNQLTSEVNLYKALGGGWNQQTVTQQQTAKK
EDPQA
Number of residues
485
Molecular Weight
52597.63
Theoretical pI
Not Available
GO Classification
Functions
efflux transmembrane transporter activity / xenobiotic transmembrane transporter activity
Processes
response to antibiotic
Components
cell outer membrane / integral component of membrane
General Function
The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the MexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane.
Specific Function
Efflux transmembrane transporter activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell outer membrane
Gene sequence
>lcl|BSEQ0052196|Outer membrane protein OprM (oprM)
ATGAAACGGTCCTTCCTTTCCCTGGCGGTAGCCGCTGTCGTTCTGTCCGGCTGCTCGCTG
ATCCCCGACTACCAGCGCCCCGAGGCGCCGGTAGCCGCGGCCTACCCGCAAGGGCAGGCC
TACGGGCAGAACACCGGCGCGGCGGCCGTTCCGGCCGCCGACATCGGCTGGCGCGAGTTC
TTCCGCGACCCGCAGTTGCAGCAACTGATCGGCGTGGCGCTGGAAAACAACCGCGACCTG
CGGGTCGCCGCGCTGAACGTCGAGGCCTTCCGGGCGCAGTACCGCATCCAGCGGGCCGAC
CTGTTCCCGCGGATCGGCGTGGACGGTAGCGGCACCCGCCAGCGTTTGCCGGGCGACCTG
TCGACCACCGGCAGTCCGGCGATTTCCAGCCAGTACGGGGTGACCCTGGGCACTACCGCC
TGGGAACTCGATCTCTTCGGCCGCCTGCGCAGCCTGCGCGACCAGGCCCTGGAGCAGTAC
CTGGCGACCGAACAGGCGCAGCGCAGCGCGCAGACCACCCTGGTGGCCAGCGTGGCGACC
GCCTACCTGACGCTGAAGGCCGACCAGGCGCAGTTGCAGCTGACCAAGGACACCCTGGGC
ACCTACCAGAAGAGTTTCGACCTGACCCAGCGCAGCTACGACGTCGGCGTCGCCTCCGCG
CTCGACCTGCGCCAGGCGCAGACCGCCGTGGAAGGCGCCCGCGCGACCCTGGCGCAGTAC
ACCCGCCTGGTAGCCCAGGACCAGAATGCGCTGGTCCTGCTGCTGGGCTCCGGGATCCCG
GCGAACCTGCCGCAAGGCCTGGGCCTGGACCAGACCCTGCTGACCGAAGTGCCGGCGGGT
CTGCCGTCGGACCTGCTGCAACGGCGCCCGGACATCCTCGAGGCCGAGCACCAGCTCATG
GCTGCCAACGCCAGCATCGGCGCCGCGCGCGCGGCGTTCTTCCCGAGCATCAGCCTGACC
GCCAACGCCGGCACCATGAGCCGCCAACTGTCCGGCCTGTTCGACGCCGGTTCGGGTTCC
TGGTTGTTCCAGCCGTCGATCAACCTGCCGATCTTCACCGCCGGCAGCCTGCGTGCCAGC
CTGGACTACGCGAAGATCCAGAAGGACATCAACGTCGCGCAGTACGAGAAGGCGATCCAG
ACGGCGTTCCAGGAAGTCGCCGACGGCCTGGCCGCGCGCGGTACCTTCACCGAGCAGTTG
CAGGCGCAGCGCGATCTGGTCAAGGCCAGCGACGAGTACTACCAGCTCGCCGACAAGCGC
TATCGCACGGGGGTGGACAACTACCTGACCCTGCTCGACGCGCAACGCTCGCTGTTCACC
GCGCAGCAGCAACTGATCACCGACCGCCTCAATCAGCTGACCAGCGAGGTCAACCTGTAC
AAGGCCCTCGGCGGCGGCTGGAACCAGCAGACCGTGACCCAGCAGCAGACCGCGAAGAAG
GAAGATCCCCAGGCTTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ51487
UniProtKB Entry NameOPRM_PSEAE
General References
  1. Poole K, Krebes K, McNally C, Neshat S: Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J Bacteriol. 1993 Nov;175(22):7363-72. [Article]
  2. Nakajima A, Sugimoto Y, Yoneyama H, Nakae T: Localization of the outer membrane subunit OprM of resistance-nodulation-cell division family multicomponent efflux pump in Pseudomonas aeruginosa. J Biol Chem. 2000 Sep 29;275(39):30064-8. doi: 10.1074/jbc.M005742200. [Article]
  3. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
  4. Poole K, Heinrichs DE, Neshat S: Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: regulation by iron and possible involvement in the secretion of the siderophore pyoverdine. Mol Microbiol. 1993 Nov;10(3):529-44. [Article]
  5. Blonder J, Goshe MB, Xiao W, Camp DG 2nd, Wingerd M, Davis RW, Smith RD: Global analysis of the membrane subproteome of Pseudomonas aeruginosa using liquid chromatography-tandem mass spectrometry. J Proteome Res. 2004 May-Jun;3(3):434-44. [Article]
  6. Li XZ, Nikaido H, Poole K: Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1995 Sep;39(9):1948-53. [Article]
  7. Srikumar R, Li XZ, Poole K: Inner membrane efflux components are responsible for beta-lactam specificity of multidrug efflux pumps in Pseudomonas aeruginosa. J Bacteriol. 1997 Dec;179(24):7875-81. doi: 10.1128/jb.179.24.7875-7881.1997. [Article]
  8. Li XZ, Zhang L, Poole K: Role of the multidrug efflux systems of Pseudomonas aeruginosa in organic solvent tolerance. J Bacteriol. 1998 Jun;180(11):2987-91. [Article]
  9. Masuda N, Sakagawa E, Ohya S, Gotoh N, Tsujimoto H, Nishino T: Contribution of the MexX-MexY-oprM efflux system to intrinsic resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2000 Sep;44(9):2242-6. doi: 10.1128/aac.44.9.2242-2246.2000. [Article]
  10. Li XZ, Poole K: Mutational analysis of the OprM outer membrane component of the MexA-MexB-OprM multidrug efflux system of Pseudomonas aeruginosa. J Bacteriol. 2001 Jan;183(1):12-27. doi: 10.1128/JB.183.1.12-27.2001. [Article]
  11. Akama H, Kanemaki M, Yoshimura M, Tsukihara T, Kashiwagi T, Yoneyama H, Narita S, Nakagawa A, Nakae T: Crystal structure of the drug discharge outer membrane protein, OprM, of Pseudomonas aeruginosa: dual modes of membrane anchoring and occluded cavity end. J Biol Chem. 2004 Dec 17;279(51):52816-9. doi: 10.1074/jbc.C400445200. Epub 2004 Oct 26. [Article]
  12. Lambert O, Benabdelhak H, Chami M, Jouan L, Nouaille E, Ducruix A, Brisson A: Trimeric structure of OprN and OprM efflux proteins from Pseudomonas aeruginosa, by 2D electron crystallography. J Struct Biol. 2005 Apr;150(1):50-7. doi: 10.1016/j.jsb.2005.01.001. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB14879Cefiderocolapproved, investigationalnosubstrateDetails