Cell division protein
Details
- Name
- Cell division protein
- Synonyms
- ftsI
- ftsI_1
- ftsI_2
- Penicillin-binding protein 3
- Peptidoglycan synthase FtsI
- Gene Name
- pbpB
- Organism
- Pseudomonas aeruginosa
- Amino acid sequence
>lcl|BSEQ0022449|Cell division protein MKLNYFQGALYPWRFCVIVGLLLAMVGAIVWRIVDLHVIDHDFLKGQGDARSVRHIAIPA HRGLITDRNGEPLAVSTPVTTLWANPKELMTAKERWPQLAAALGQDTKLFADRIEQNAER EFIYLVRGLTPEQGEGVIALKVPGVYSIEEFRRFYPAGEVVAHAVGFTDVDDRGREGIEL AFDEWLAGVPGKRQVLKDRRGRVIKDVQVTKNAKPGKTLALSIDLRLQYLAHRELRNALL ENGAKAGSLVIMDVKTGEILAMTNQPTYNPNNRRNLQPAAMRNRAMIDVFEPGSTVKPFS MSAALASGRWKPSDIVDVYPGTLQIGRYTIRDVSRNSRQLDLTGILIKSSNVGISKIAFD IGAESIYSVMQQVGLGQDTGLGFPGERVGNLPNHRKWPKAETATLAYGYGLSVTAIQLAH AYAALANDGKSVPLSMTRVDRVPDGVQVISPEVASTVQGMLQQVVEAQGGVFRAQVPGYH AAGKSGTARKVSVGTKGYRENAYRSLFAGFAPATDPRIAMVVVIDEPSKAGYFGGLVSAP VFSKVMAGALRLMNVPPDNLPTATEQQQVNAAPAKGGRG
- Number of residues
- 579
- Molecular Weight
- 62855.78
- Theoretical pI
- Not Available
- GO Classification
- Functionspenicillin binding / peptidoglycan glycosyltransferase activityProcessescell divisionComponentsintegral component of membrane
- General Function
- Peptidoglycan glycosyltransferase activity
- Specific Function
- Not Available
- Pfam Domain Function
- Transmembrane Regions
- 12-34
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0022450|Cell division protein (pbpB) ATGAAACTGAATTATTTCCAGGGCGCCCTCTACCCATGGCGGTTCTGCGTGATCGTCGGC CTGCTGCTGGCGATGGTCGGCGCCATCGTCTGGCGAATCGTCGACCTGCACGTGATCGAC CATGACTTCCTCAAGGGCCAGGGCGACGCGCGTAGCGTGCGGCATATCGCCATCCCTGCG CACCGGGGCCTGATCACTGACCGCAACGGCGAACCGCTGGCGGTGAGCACCCCGGTCACC ACCCTGTGGGCCAACCCCAAGGAGCTGATGACCGCCAAGGAACGCTGGCCGCAACTGGCG GCGGCGCTCGGGCAGGATACCAAGCTGTTCGCCGACCGCATCGAGCAGAACGCCGAGCGC GAGTTCATCTATCTGGTCCGTGGGCTGACCCCGGAGCAGGGCGAAGGCGTGATCGCCCTG AAGGTGCCCGGCGTGTACTCCATCGAGGAGTTTCGGCGTTTCTACCCGGCTGGCGAAGTG GTGGCCCATGCGGTCGGCTTTACCGATGTCGACGACCGCGGTCGCGAAGGTATCGAGCTG GCTTTCGACGAATGGCTGGCCGGCGTGCCGGGCAAGCGCCAGGTGCTCAAGGATCGCCGT GGCCGCGTGATCAAGGACGTGCAGGTCACCAAGAATGCCAAACCGGGCAAGACCCTTGCG CTGTCCATCGACCTGCGCCTGCAGTACCTGGCTCATCGCGAACTGCGCAACGCTCTGCTG GAAAACGGCGCCAAGGCCGGCAGCTTGGTGATCATGGACGTGAAGACCGGGGAGATCCTG GCCATGACCAACCAGCCCACCTACAACCCGAACAATCGTCGTAACCTGCAGCCGGCGGCC ATGCGCAACCGGGCGATGATCGACGTGTTCGAGCCGGGCTCGACGGTCAAGCCGTTCTCG ATGAGCGCGGCGCTGGCCAGCGGGCGCTGGAAACCCAGCGATATCGTCGACGTCTACCCG GGCACCCTGCAGATCGGCCGCTACACCATTCGCGACGTATCGCGCAATTCGCGGCAACTC GATCTCACCGGCATCCTGATCAAGTCGAGCAACGTCGGCATCAGCAAGATCGCCTTCGAC ATCGGCGCCGAATCCATCTACTCGGTCATGCAACAGGTCGGTCTCGGGCAGGACACGGGG TTGGGCTTCCCCGGCGAGCGCGTCGGCAACCTGCCCAACCACCGCAAGTGGCCGAAGGCG GAAACCGCGACCCTGGCCTACGGCTACGGTCTCTCGGTAACCGCGATCCAGTTGGCGCAT GCCTATGCGGCCCTGGCCAACGACGGCAAGAGCGTGCCGCTGAGCATGACCCGAGTCGAC CGCGTGCCGGATGGTGTGCAGGTGATCTCGCCTGAAGTGGCTTCCACCGTGCAGGGCATG CTGCAACAAGTGGTCGAGGCCCAGGGCGGGGTGTTCCGCGCCCAGGTGCCGGGTTACCAC GCCGCCGGCAAGAGCGGGACCGCGCGCAAGGTCTCGGTCGGCACCAAGGGCTACCGGGAA AACGCCTATCGCTCGCTGTTCGCCGGTTTCGCCCCGGCCACCGATCCGCGCATCGCGATG GTCGTGGTGATCGACGAGCCGAGCAAGGCGGGCTACTTCGGCGGCCTGGTGTCGGCGCCG GTGTTCAGTAAGGTCATGGCTGGCGCGCTGCGCCTGATGAACGTGCCGCCGGATAACCTG CCGACGGCCACCGAACAGCAGCAGGTCAATGCTGCGCCCGCAAAAGGAGGGCGTGGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q51504 UniProtKB Entry Name Q51504_PSEAI - General References
- Liao X, Hancock RE: Cloning and characterization of the Pseudomonas aeruginosa pbpB gene encoding penicillin-binding protein 3. Antimicrob Agents Chemother. 1995 Aug;39(8):1871-4. [Article]
- Han S, Zaniewski RP, Marr ES, Lacey BM, Tomaras AP, Evdokimov A, Miller JR, Shanmugasundaram V: Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22002-7. doi: 10.1073/pnas.1013092107. Epub 2010 Dec 6. [Article]
- Sainsbury S, Bird L, Rao V, Shepherd SM, Stuart DI, Hunter WN, Owens RJ, Ren J: Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms. J Mol Biol. 2011 Jan 7;405(1):173-84. doi: 10.1016/j.jmb.2010.10.024. Epub 2010 Oct 23. [Article]
- Mitton-Fry MJ, Arcari JT, Brown MF, Casavant JM, Finegan SM, Flanagan ME, Gao H, George DM, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Irvine R, Lall MS, Megan Lemmon M, Li C, Lin J, McCurdy SP, Mueller JP, Mullins L, Niosi M, Noe MC, Pattavina D, Penzien J, Plummer MS, Risley H, Schuff BP, Shanmugasundaram V, Starr JT, Sun J, Winton J, Young JA: Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5989-94. doi: 10.1016/j.bmcl.2012.07.005. Epub 2012 Jul 20. [Article]
- Brown MF, Mitton-Fry MJ, Arcari JT, Barham R, Casavant J, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Lall MS, Lemmon MM, Li C, Lin J, McCurdy SP, McElroy E, McPherson C, Marr ES, Mueller JP, Mullins L, Nikitenko AA, Noe MC, Penzien J, Plummer MS, Schuff BP, Shanmugasundaram V, Starr JT, Sun J, Tomaras A, Young JA, Zaniewski RP: Pyridone-conjugated monobactam antibiotics with gram-negative activity. J Med Chem. 2013 Jul 11;56(13):5541-52. doi: 10.1021/jm400560z. Epub 2013 Jun 27. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01413 Cefepime approved, investigational yes inhibitor Details DB09050 Ceftolozane approved, investigational yes inhibitor Details DB06211 Doripenem approved, investigational yes antagonistinhibitor Details DB14879 Cefiderocol approved, investigational yes inhibitor Details