Phosphonoacetate hydrolase

Details

Name
Phosphonoacetate hydrolase
Synonyms
  • 3.11.1.2
Gene Name
phnA
Organism
Pseudomonas fluorescens
Amino acid sequence
>lcl|BSEQ0022283|Phosphonoacetate hydrolase
MTQLISVNSRSYRLSSAPTIVICVDGCEQEYINQAIQAGQAPFLAELTGFGTVLTGDCVV
PSFTNPNNLSIVTGAPPSVHGICGNFFFDQETQEEVLMNDAKYLRAPTILAEMAKAGQLV
AVVTAKDKLRNLLGHQLKGICFSAEKADQVNLEEHGVENILARVGMPVPSVYSADLSEFV
FAAGLSLLTNERPDFMYLSTTDYVQHKHAPGTPEANAFYAMMDSYFKRYHEQGAIVAITA
DHGMNAKTDAIGRPNILFLQDLLDAQYGAQRTRVLLPITDPYVVHHGALGSYATVYLRDA
VPQRDAIDFLAGIAGVEAVLTRSQACQRFELPEDRIGDLVVLGERLTVLGSAADKHDLSG
LTVPLRSHGGVSEQKVPLIFNRKLVGLDSPGRLRNFDIIDLALNHLA
Number of residues
407
Molecular Weight
44239.04
Theoretical pI
5.37
GO Classification
Functions
metal ion binding / phosphonoacetate hydrolase activity
Processes
phosphonoacetate metabolic process
General Function
Phosphonoacetate hydrolase activity
Specific Function
Specifically hydrolyzes phosphonoacetate. Does not have activity on other organophosphonates or acetates.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0004924|1224 bp
ATGACACAACTTATCAGCGTGAACTCGCGCTCCTATCGCCTGTCGTCGGCACCGACGATT
GTTATCTGCGTCGACGGATGCGAGCAGGAATACATCAATCAAGCCATTCAAGCCGGACAG
GCACCGTTTCTCGCCGAACTTACCGGCTTCGGCACAGTGTTGACTGGCGATTGCGTGGTG
CCTTCGTTCACCAACCCGAACAATCTGTCGATCGTTACCGGGGCCCCGCCATCCGTTCAC
GGTATTTGCGGCAACTTCTTTTTTGACCAGGAGACGCAAGAGGAGGTGTTGATGAACGAC
GCGAAGTACCTTCGCGCGCCGACTATTCTTGCCGAGATGGCCAAAGCGGGCCAGCTCGTC
GCCGTGGTGACCGCAAAGGACAAGTTGCGCAACTTGCTGGGGCATCAACTGAAAGGGATC
TGTTTTTCCGCTGAAAAAGCCGACCAGGTGAATCTGGAGGAACACGGTGTCGAGAACATC
CTGGCAAGAGTCGGCATGCCCGTGCCTTCGGTATACAGCGCAGACCTTTCCGAGTTCGTG
TTTGCCGCCGGCCTCTCGTTGTTGACCAACGAACGCCCCGACTTCATGTACCTGTCCACT
ACCGATTATGTACAACACAAACATGCGCCAGGCACACCCGAAGCCAATGCGTTCTACGCA
ATGATGGACAGCTACTTCAAGCGTTATCACGAGCAAGGCGCGATCGTGGCGATTACGGCG
GATCACGGCATGAATGCCAAGACCGATGCGATAGGTCGCCCCAACATCCTGTTTTTGCAA
GACCTTCTCGATGCCCAATATGGCGCGCAGCGCACACGGGTATTACTGCCGATCACCGAC
CCTTACGTAGTGCATCACGGCGCGCTGGGCTCTTACGCGACCGTGTACTTGCGCGATGCG
GTACCGCAGCGCGATGCCATCGACTTTCTCGCAGGCATCGCCGGTGTCGAGGCAGTCTTG
ACGCGTTCGCAGGCCTGCCAGCGATTCGAACTGCCCGAAGACCGGATTGGCGACCTGGTG
GTACTCGGGGAACGACTGACGGTGCTTGGCAGTGCTGCCGACAAACACGACCTGTCCGGA
CTGACGGTGCCCTTGCGTTCCCACGGTGGTGTATCGGAGCAGAAAGTGCCACTGATCTTC
AACCGCAAGCTGGTCGGTCTCGACAGCCCCGGCCGACTGCGAAATTTCGACATTATCGAT
CTCGCGCTCAACCATCTCGCTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ51782
UniProtKB Entry NamePHNHY_PSEFL
GenBank Gene IDL49465
General References
  1. Kulakova AN, Kulakov LA, Quinn JP: Cloning of the phosphonoacetate hydrolase gene from Pseudomonas fluorescens 23F encoding a new type of carbon-phosphorus bond cleaving enzyme and its expression in Escherichia coli and Pseudomonas putida. Gene. 1997 Aug 11;195(1):49-53. [Article]
  2. Panas P, Ternan NG, Dooley JS, McMullan G: Detection of phosphonoacetate degradation and phnA genes in soil bacteria from distinct geographical origins suggest its possible biogenic origin. Environ Microbiol. 2006 May;8(5):939-45. [Article]
  3. McGrath JW, Wisdom GB, McMullan G, Larkin MJ, Quinn JP: The purification and properties of phosphonoacetate hydrolase, a novel carbon-phosphorus bond-cleavage enzyme from Pseudomonas fluorescens 23F. Eur J Biochem. 1995 Nov 15;234(1):225-30. [Article]
  4. McMullan G, Quinn JP: In vitro characterization of a phosphate starvation-independent carbon-phosphorus bond cleavage activity in Pseudomonas fluorescens 23F. J Bacteriol. 1994 Jan;176(2):320-4. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01694D-tartaric acidexperimentalunknownDetails