Aclacinomycin methylesterase RdmC

Details

Name
Aclacinomycin methylesterase RdmC
Synonyms
  • 3.1.1.95
Gene Name
rdmC
Organism
Streptomyces purpurascens
Amino acid sequence
>lcl|BSEQ0022290|Aclacinomycin methylesterase RdmC
MSERIVPSGDVELWSDDFGDPADPALLLVMGGNLSALGWPDEFARRLADGGLHVIRYDHR
DTGRSTTRDFAAHPYGFGELAADAVAVLDGWGVDRAHVVGLSMGATITQVIALDHHDRLS
SLTMLLGGGLDIDFDANIERVMRGEPTLDGLPGPQQPFLDALALMNQPAEGRAAEVAKRV
SKWRILSGTGVPFDDAEYARWEERAIDHAGGVLAEPYAHYSLTLPPPSRAAELREVTVPT
LVIQAEHDPIAPAPHGKHLAGLIPTARLAEIPGMGHALPSSVHGPLAEVILAHTRSAA
Number of residues
298
Molecular Weight
31791.565
Theoretical pI
4.92
GO Classification
Functions
carboxylic ester hydrolase activity
Processes
antibiotic biosynthetic process
General Function
Not Available
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0005021|897 bp
ATGTCCGAACGCATCGTGCCGAGCGGGGACGTCGAGCTGTGGAGCGACGACTTCGGTGAC
CCGGCGGACCCGGCGCTGCTGCTCGTCATGGGCGGCAACCTCTCCGCCCTCGGCTGGCCC
GACGAGTTCGCCCGGCGGCTCGCCGACGGCGGCCTCCACGTCATCCGCTACGACCACCGC
GACACCGGCCGCTCCACCACCCGCGACTTCGCCGCGCACCCCTACGGCTTCGGCGAGCTG
GCCGCCGACGCGGTCGCCGTCCTCGACGGCTGGGGCGTCGACCGGGCCCATGTCGTCGGC
CTCTCGATGGGGGCGACCATCACCCAGGTCATCGCCCTCGACCACCACGACCGGCTGAGC
AGCCTGACCATGCTGCTCGGCGGCGGGCTCGACATCGACTTCGACGCCAACATCGAGCGC
GTGATGCGCGGCGAACCCACGCTGGACGGCCTGCCCGGGCCCCAGCAGCCGTTCCTGGAC
GCGCTCGCCCTGATGAACCAGCCGGCCGAGGGACGCGCCGCCGAGGTGGCCAAGCGCGTG
AGCAAGTGGCGCATCCTCTCCGGCACGGGTGTGCCGTTCGACGACGCCGAGTACGCGCGG
TGGGAGGAACGGGCGATCGACCACGCGGGGGGCGTCCTCGCCGAGCCGTACGCGCACTAC
TCGCTGACCCTGCCGCCGCCGTCCCGGGCCGCCGAGCTGCGCGAGGTCACCGTGCCGACC
CTGGTCATCCAGGCCGAGCACGACCCCATCGCCCCCGCGCCGCACGGCAAGCACCTCGCC
GGGCTCATCCCCACCGCGCGCCTCGCGGAGATCCCGGGCATGGGGCACGCCCTGCCTTCC
TCGGTCCACGGGCCGCTCGCCGAGGTCATCCTCGCCCACACCCGCTCGGCGGCCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ54528
UniProtKB Entry NameRDMC_STREF
GenBank Gene IDU10405
General References
  1. Niemi J, Ylihonko K, Hakala J, Parssinen R, Kopio A, Mantsala P: Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus. Microbiology. 1994 Jun;140 ( Pt 6):1351-8. [Article]
  2. Niemi J, Mantsala P: Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus. J Bacteriol. 1995 May;177(10):2942-5. [Article]
  3. Wang Y, Niemi J, Airas K, Ylihonko K, Hakala J, Mantsala P: Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens. Biochim Biophys Acta. 2000 Jul 14;1480(1-2):191-200. [Article]
  4. Jansson A, Niemi J, Mantsala P, Schneider G: Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism. J Biol Chem. 2003 Oct 3;278(40):39006-13. Epub 2003 Jul 23. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB0180610-decarboxymethylaclacinomycin AexperimentalunknownDetails
DB0413110-(4-Dimethylamino-5-Hydroxy-6-Methyl-Tetrahydro-Pyran-2-Yloxy)-8-Ethyl-1,8,11-Trihydroxy-7,8,9,10-Tetrahydro-Naphthacene-5,12-DioneexperimentalunknownDetails