Aclacinomycin methylesterase RdmC
Details
- Name
- Aclacinomycin methylesterase RdmC
- Synonyms
- 3.1.1.95
- Gene Name
- rdmC
- Organism
- Streptomyces purpurascens
- Amino acid sequence
>lcl|BSEQ0022290|Aclacinomycin methylesterase RdmC MSERIVPSGDVELWSDDFGDPADPALLLVMGGNLSALGWPDEFARRLADGGLHVIRYDHR DTGRSTTRDFAAHPYGFGELAADAVAVLDGWGVDRAHVVGLSMGATITQVIALDHHDRLS SLTMLLGGGLDIDFDANIERVMRGEPTLDGLPGPQQPFLDALALMNQPAEGRAAEVAKRV SKWRILSGTGVPFDDAEYARWEERAIDHAGGVLAEPYAHYSLTLPPPSRAAELREVTVPT LVIQAEHDPIAPAPHGKHLAGLIPTARLAEIPGMGHALPSSVHGPLAEVILAHTRSAA
- Number of residues
- 298
- Molecular Weight
- 31791.565
- Theoretical pI
- 4.92
- GO Classification
- Functionscarboxylic ester hydrolase activityProcessesantibiotic biosynthetic process
- General Function
- Not Available
- Specific Function
- Not Available
- Pfam Domain Function
- Abhydrolase_1 (PF00561)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0005021|897 bp ATGTCCGAACGCATCGTGCCGAGCGGGGACGTCGAGCTGTGGAGCGACGACTTCGGTGAC CCGGCGGACCCGGCGCTGCTGCTCGTCATGGGCGGCAACCTCTCCGCCCTCGGCTGGCCC GACGAGTTCGCCCGGCGGCTCGCCGACGGCGGCCTCCACGTCATCCGCTACGACCACCGC GACACCGGCCGCTCCACCACCCGCGACTTCGCCGCGCACCCCTACGGCTTCGGCGAGCTG GCCGCCGACGCGGTCGCCGTCCTCGACGGCTGGGGCGTCGACCGGGCCCATGTCGTCGGC CTCTCGATGGGGGCGACCATCACCCAGGTCATCGCCCTCGACCACCACGACCGGCTGAGC AGCCTGACCATGCTGCTCGGCGGCGGGCTCGACATCGACTTCGACGCCAACATCGAGCGC GTGATGCGCGGCGAACCCACGCTGGACGGCCTGCCCGGGCCCCAGCAGCCGTTCCTGGAC GCGCTCGCCCTGATGAACCAGCCGGCCGAGGGACGCGCCGCCGAGGTGGCCAAGCGCGTG AGCAAGTGGCGCATCCTCTCCGGCACGGGTGTGCCGTTCGACGACGCCGAGTACGCGCGG TGGGAGGAACGGGCGATCGACCACGCGGGGGGCGTCCTCGCCGAGCCGTACGCGCACTAC TCGCTGACCCTGCCGCCGCCGTCCCGGGCCGCCGAGCTGCGCGAGGTCACCGTGCCGACC CTGGTCATCCAGGCCGAGCACGACCCCATCGCCCCCGCGCCGCACGGCAAGCACCTCGCC GGGCTCATCCCCACCGCGCGCCTCGCGGAGATCCCGGGCATGGGGCACGCCCTGCCTTCC TCGGTCCACGGGCCGCTCGCCGAGGTCATCCTCGCCCACACCCGCTCGGCGGCCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q54528 UniProtKB Entry Name RDMC_STREF GenBank Gene ID U10405 - General References
- Niemi J, Ylihonko K, Hakala J, Parssinen R, Kopio A, Mantsala P: Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus. Microbiology. 1994 Jun;140 ( Pt 6):1351-8. [Article]
- Niemi J, Mantsala P: Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus. J Bacteriol. 1995 May;177(10):2942-5. [Article]
- Wang Y, Niemi J, Airas K, Ylihonko K, Hakala J, Mantsala P: Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens. Biochim Biophys Acta. 2000 Jul 14;1480(1-2):191-200. [Article]
- Jansson A, Niemi J, Mantsala P, Schneider G: Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism. J Biol Chem. 2003 Oct 3;278(40):39006-13. Epub 2003 Jul 23. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01806 10-decarboxymethylaclacinomycin A experimental unknown Details DB04131 10-(4-Dimethylamino-5-Hydroxy-6-Methyl-Tetrahydro-Pyran-2-Yloxy)-8-Ethyl-1,8,11-Trihydroxy-7,8,9,10-Tetrahydro-Naphthacene-5,12-Dione experimental unknown Details