DNA topoisomerase 4 subunit B

Details

Name
DNA topoisomerase 4 subunit B
Synonyms
  • 5.99.1.3
  • Topoisomerase IV subunit B
Gene Name
parE
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Amino acid sequence
>lcl|BSEQ0012600|DNA topoisomerase 4 subunit B
MSKKEININNYNDDAIQVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGF
GDRIDVTINKDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLH
GVGSSVVNALSSWLEVEITRDGAVYKQRFENGGKPVTTLKKIGTAPKSKTGTKVTFMPDA
TIFSTTDFKYNTISERLNESAFLLKNVTLSLTDKRTNEAIEFHYENGVQDFVSYLNEDKE
ILTPVLYFEGEDNGFQVEVALQYNDGFSDNILSFVNNVRTKDGGTHETGLKSAITKVMND
YARKTGLLKEKDKNLEGSDYREGLAAVLSILVPEEHLQFEGQTKDKLGSPLARPVVDGIV
ADKLTFFLMENGELASNLIRKAIKARDAREAARKARDESRNGKKNKKDKGLLSGKLTPAQ
SKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVVNTAKAKMADILKNEEINTMI
YTIGAGVGADFSIEDANYDKIIIMTDADTDGAHIQTLLLTFFYRYMRPLVEAGHVYIALP
PLYKMSKGKGKKEEVAYAWTDGELEELRKQFGKGATLQRYKGLGEMNADQLWETTMNPET
RTLIRVTIEDLARAERRVNVLMGDKVEPRRKWIEDNVKFTLEETTVF
Number of residues
647
Molecular Weight
71663.86
Theoretical pI
6.77
GO Classification
Functions
ATP binding / DNA binding / DNA topoisomerase type II (ATP-hydrolyzing) activity / magnesium ion binding
Processes
chromosome segregation / DNA topological change
Components
chromosome
General Function
Magnesium ion binding
Specific Function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0012601|DNA topoisomerase 4 subunit B (parE)
GTGTCAAAAAAGGAAATCAATATTAACAATTATAATGATGATGCTATTCAGGTGCTAGAA
GGGTTGGATGCGGTCCGAAAACGTCCAGGGATGTATATTGGATCGACCGATGGCGCTGGT
CTTCATCACCTAGTTTGGGAAATCGTTGATAATGCAGTCGATGAAGCCTTGTCTGGGTTT
GGTGATCGTATTGATGTAACTATCAATAAAGACGGTAGTCTAACGGTTCAAGACCATGGA
CGTGGGATGCCGACAGGTATGCACGCTATGGGAATTCCAACTGTTGAGGTTATCTTTACC
ATTCTTCATGCCGGAGGGAAATTCGGTCAAGGTGGCTATAAGACATCAGGTGGACTTCAC
GGAGTGGGTTCTTCCGTTGTTAACGCCCTTTCTAGCTGGTTAGAAGTTGAAATTACCCGT
GATGGCGCAGTTTACAAGCAACGTTTCGAAAATGGTGGAAAACCTGTCACGACTTTGAAG
AAAATCGGTACAGCACCCAAGTCTAAAACAGGCACCAAAGTTACTTTTATGCCTGACGCG
ACTATATTTTCTACGACAGATTTCAAGTACAATACCATTTCAGAGCGCCTTAATGAATCA
GCCTTTCTCTTGAAAAATGTGACCTTGTCTTTAACGGACAAGCGAACAAATGAAGCGATT
GAGTTCCACTATGAGAATGGAGTACAAGATTTTGTTTCTTATCTCAACGAAGATAAGGAA
ATCTTGACGCCAGTTCTTTACTTTGAAGGGGAAGACAATGGTTTTCAAGTGGAAGTAGCC
CTCCAGTACAATGACGGATTCTCAGATAACATTCTATCTTTTGTCAATAACGTTCGCACC
AAGGACGGTGGAACGCACGAGACAGGACTCAAGTCTGCCATTACCAAGGTCATGAATGAC
TATGCACGTAAAACAGGTCTTCTCAAGGAAAAAGATAAAAACCTTGAAGGTTCAGACTAT
CGTGAGGGACTAGCGGCCGTTCTTTCTATCTTAGTTCCTGAAGAACACTTGCAGTTTGAA
GGACAGACCAAGGATAAACTAGGAAGCCCCCTAGCTCGCCCAGTTGTGGATGGAATAGTG
GCTGATAAGTTGACCTTTTTCCTTATGGAAAATGGGGAATTAGCTTCTAACCTCATCCGC
AAGGCTATCAAGGCCCGTGATGCTCGTGAAGCAGCACGTAAGGCGCGTGATGAGAGCCGA
AATGGGAAGAAAAACAAGAAAGATAAGGGCTTGTTGTCTGGGAAATTGACCCCAGCCCAA
TCTAAGAATCCTGCTAAGAATGAACTCTATCTAGTTGAGGGGGACTCTGCCGGTGGTTCT
GCCAAACAAGGTCGTGACCGCAAGTTCCAGGCTATTCTACCTCTTCGTGGTAAGGTTGTC
AATACAGCCAAGGCCAAGATGGCGGATATCCTCAAAAATGAAGAGATCAATACCATGATT
TATACCATTGGTGCGGGTGTTGGAGCAGACTTCTCTATTGAAGATGCCAACTATGATAAG
ATCATTATCATGACCGATGCGGATACCGACGGTGCCCATATCCAGACCTTGCTCTTGACA
TTTTTCTACCGTTACATGCGTCCGCTAGTCGAGGCAGGTCATGTCTATATTGCCCTCCCA
CCTCTTTACAAGATGTCCAAAGGTAAAGGCAAGAAAGAAGAAGTGGCCTACGCTTGGACG
GACGGAGAACTAGAAGAACTCCGTAAACAGTTCGGTAAAGGCGCTACCCTCCAACGATAC
AAAGGACTTGGTGAGATGAATGCGGACCAGCTCTGGGAAACAACCATGAACCCAGAAACA
CGTACCCTCATCCGTGTCACAATTGAAGATTTAGCGCGCGCCGAACGCCGCGTCAATGTT
CTCATGGGAGATAAGGTAGAACCACGCCGTAAATGGATTGAAGATAATGTCAAGTTTACG
CTAGAAGAAACGACAGTGTTTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ59961
UniProtKB Entry NamePARE_STRPN
GenBank Protein ID1490399
GenBank Gene IDZ67739
General References
  1. Pan XS, Fisher LM: Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance. J Bacteriol. 1996 Jul;178(14):4060-9. [Article]
  2. Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM: Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science. 2001 Jul 20;293(5529):498-506. [Article]
  3. Munoz R, De La Campa AG: ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype. Antimicrob Agents Chemother. 1996 Oct;40(10):2252-7. [Article]
  4. Laponogov I, Veselkov DA, Sohi MK, Pan XS, Achari A, Yang C, Ferrara JD, Fisher LM, Sanderson MR: Breakage-reunion domain of Streptococcus pneumoniae topoisomerase IV: crystal structure of a gram-positive quinolone target. PLoS One. 2007 Mar 21;2(3):e301. [Article]
  5. Laponogov I, Sohi MK, Veselkov DA, Pan XS, Sawhney R, Thompson AW, McAuley KE, Fisher LM, Sanderson MR: Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases. Nat Struct Mol Biol. 2009 Jun;16(6):667-9. doi: 10.1038/nsmb.1604. Epub 2009 May 17. [Article]
  6. Laponogov I, Pan XS, Veselkov DA, McAuley KE, Fisher LM, Sanderson MR: Structural basis of gate-DNA breakage and resealing by type II topoisomerases. PLoS One. 2010 Jun 28;5(6):e11338. doi: 10.1371/journal.pone.0011338. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01044Gatifloxacinapproved, investigational, withdrawnyesinhibitorDetails