Serine/threonine-protein kinase TNNI3K
Details
- Name
- Serine/threonine-protein kinase TNNI3K
- Synonyms
- 2.7.11.1
- Cardiac ankyrin repeat kinase
- Cardiac troponin I-interacting kinase
- CARK
- TNNI3-interacting kinase
- Gene Name
- TNNI3K
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051680|Serine/threonine-protein kinase TNNI3K MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNL NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSL LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL DNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPG GDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKG RCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQ YISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDG HAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT GEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE ECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAA LSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
- Number of residues
- 835
- Molecular Weight
- 92849.73
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / metal ion binding / protein C-terminus binding / protein kinase activity / protein serine/threonine kinase activity / signal transducer activity / troponin I bindingProcessesbundle of His cell to Purkinje myocyte communication / intracellular signal transduction / protein phosphorylation / regulation of cardiac conduction / regulation of cardiac muscle contraction / regulation of heart rateComponentscytoplasm / nucleus
- General Function
- May play a role in cardiac physiology.
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0051681|Serine/threonine-protein kinase TNNI3K (TNNI3K) ATGCGTGCTGTGCGGCGCGGTCTCAGGGAAGGTGGGGCTATGGCAGCTGCTAGGGACCCT CCGGAAGTATCGCTGCGAGAAGCCACCCAGCGAAAATTGCGGAGGTTTTCCGAGCTAAGA GGCAAACTTGTAGCACGTGGAGAATTCTGGGACATAGTTGCAATAACAGCGGCTGATGAA AAACAGGAACTTGCTTACAACCAACAGCTGTCAGAAAAGCTGAAAAGAAAGGAGTTACCC CTTGGAGTTCAATATCACGTTTTTGTGGATCCTGCTGGAGCCAAAATTGGAAATGGAGGA TCAACACTTTGTGCCCTTCAATGTTTGGAAAAGCTATATGGAGATAAATGGAATTCTTTT ACCATCTTATTAATTCACTCTGATGAATGGAAGAAAAAAGTCAGTGAATCATATGTTATC ACAATAGAAAGATTAGAAGATGACCTGCAGATCAAGGAAAAAGAACTGACAGAACTAAGG AATATATTTGGCTCTGATGAAGCCTTCAGTAAAGTCAATTTAAATTACCGCACTGAAAAT GGGCTGTCTCTACTTCATTTATGTTGCATTTGTGGAGGCAAGAAATCACATATTCGAACT CTTATGTTGAAAGGGCTCCGCCCATCTCGACTGACAAGAAATGGATTTACAGCCTTGCAT TTAGCAGTTTACAAGGATAATGCAGAATTGATCACTTCTCTGCTTCACAGTGGAGCTGAT ATACAGCAGGTTGGATACGGTGGCCTCACTGCCCTCCATATTGCTACAATAGCTGGCCAC CTAGAGGCTGCTGATGTGCTGTTGCAACATGGAGCTAATGTCAATATTCAAGATGCAGTT TTTTTCACTCCATTGCATATTGCAGCGTACTATGGACATGAACAGGTAACTCGCCTTCTT TTGAAATTTGGTGCTGATGTAAATGTAAGTGGTGAAGTTGGAGATAGACCCCTCCACCTA GCATCTGCAAAAGGATTCTTGAATATTGCAAAACTCTTGATGGAAGAAGGCAGCAAAGCA GATGTGAATGCTCAAGATAATGAAGACCATGTCCCACTCCATTTCTGTTCTCGATTTGGA CACCATGATATAGTTAAGTATCTGCTGCAAAGTGATTTGGAAGTTCAACCTCATGTTGTT AATATCTATGGAGATACCCCCTTACACCTGGCATGCTACAATGGCAAATTTGAAGTTGCC AAGGAAATCATCCAAATATCAGGAACAGAAAGTCTGACTAAGGAAAACATCTTCAGTGAA ACAGCTTTTCATAGTGCTTGTACCTATGGCAAGAGCATTGACCTAGTCAAATTTCTTCTT GATCAGAATGTCATAAACATCAACCACCAAGGAAGGGATGGGCACACTGGATTACACTCT GCTTGCTACCACGGTCACATTCGCCTGGTTCAGTTCTTACTGGATAATGGAGCTGATATG AATCTAGTGGCTTGTGATCCCAGCAGGTCTAGTGGTGAAAAAGATGAGCAGACATGTTTG ATGTGGGCTTATGAAAAAGGGCATGATGCCATTGTCACACTCCTGAAGCATTATAAGAGA CCACAAGATGAATTGCCCTGTAATGAATATTCTCAGCCTGGAGGAGATGGCTCCTATGTG TCTGTTCCATCACCCTTGGGGAAGATTAAAAGCATGACAAAAGAGAAGGCAGATATTCTC CTCCTAAGAGCTGGATTGCCTTCACATTTCCATCTTCAGCTCTCAGAAATTGAGTTCCAT GAGATTATTGGCTCAGGTTCTTTTGGGAAAGTATATAAAGGACGATGCAGAAATAAAATA GTGGCTATAAAACGTTATCGAGCCAATACCTACTGCTCCAAGTCAGATGTGGATATGTTT TGCCGAGAGGTGTCCATTCTCTGCCAGCTCAATCATCCCTGCGTAATTCAGTTTGTGGGT GCTTGCTTGAATGATCCCAGCCAGTTTGCCATTGTCACTCAATACATATCAGGGGGTTCT CTGTTCTCCCTCCTTCATGAGCAGAAGAGGATTCTTGATTTGCAGTCTAAATTAATTATT GCAGTAGATGTTGCCAAAGGCATGGAGTACCTTCACAACCTGACACAGCCAATTATACAT CGTGACTTGAACAGTCACAATATTCTTCTCTATGAGGATGGGCATGCTGTGGTGGCAGAT TTTGGAGAATCAAGATTTCTACAGTCTCTGGATGAAGACAACATGACAAAACAACCTGGG AACCTCCGTTGGATGGCTCCTGAGGTGTTCACGCAGTGCACTCGGTACACCATCAAAGCA GATGTCTTCAGCTATGCTCTGTGTCTGTGGGAAATTCTCACTGGCGAAATTCCATTCGCT CATCTCAAGCCAGCGGCTGCGGCAGCAGACATGGCTTACCACCACATCAGACCTCCCATT GGCTATTCCATTCCCAAGCCCATATCATCTCTGCTGATACGAGGGTGGAACGCATGTCCT GAAGCAAAATCCAGACCAAGTCATTACCCAGTCTCATCTGTGTACACAGAAACTCTTAAG AAGAAAAATGAAGATCGTTTTGGGATGTGGATTGAGTATCTCAGAAGATAA
- Chromosome Location
- 1
- Locus
- 1p31.1
- External Identifiers
Resource Link UniProtKB ID Q59H18 UniProtKB Entry Name TNI3K_HUMAN HGNC ID HGNC:19661 - General References
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- Theis JL, Zimmermann MT, Larsen BT, Rybakova IN, Long PA, Evans JM, Middha S, de Andrade M, Moss RL, Wieben ED, Michels VV, Olson TM: TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy. Hum Mol Genet. 2014 Nov 1;23(21):5793-804. doi: 10.1093/hmg/ddu297. Epub 2014 Jun 11. [Article]