3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Details

Name
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
Synonyms
  • (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
  • 4.2.1.59
  • Beta-hydroxyacyl-ACP dehydratase
Gene Name
fabZ
UniProtKB Entry
Q5G940TrEMBL
Organism
Helicobacter pylori
NCBI Taxonomy ID
210
Amino acid sequence
>lcl|BSEQ0022083|3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
MEQSHQNLQSQFFIEHILQILPHRYPMLLVDRITELQANQKIVAYKNITFNEDVFNGHFP
NKPIFPGVLIVEGMAQSGGFLAFTSLWGFDPEIAKTKIVYFMTIDKVKFRIPVTPGDRLE
YHLEVLKHKGMIWQVGGTAQVDGKVVAEAELKAMIAERE
Number of residues
159
Molecular Weight
18184.08
Theoretical pI
6.81
GO Classification
Functions
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Processes
fatty acid biosynthetic process / lipid A biosynthetic process
Components
cytoplasm
General Function
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Specific Function
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity).
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ5G940
UniProtKB Entry NameQ5G940_HELPX
GenBank Protein ID56684725
GenBank Gene IDAY725427
PDB ID(s)3B7J, 3CF8, 3CF9, 3D04, 3DOY, 3DOZ, 3DP0, 3DP1, 3DP2, 3DP3, 3ED0
General References
  1. Liu W, Luo C, Han C, Peng S, Yang Y, Yue J, Shen X, Jiang H: A new beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) from Helicobacter pylori: Molecular cloning, enzymatic characterization, and structural modeling. Biochem Biophys Res Commun. 2005 Aug 12;333(4):1078-86. [Article]
  2. Kong YH, Zhang L, Yang ZY, Han C, Hu LH, Jiang HL, Shen X: Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization. Acta Pharmacol Sin. 2008 Jul;29(7):870-6. doi: 10.1111/j.1745-7254.2008.00808.x. [Article]
  3. Zhang L, Kong Y, Wu D, Zhang H, Wu J, Chen J, Ding J, Hu L, Jiang H, Shen X: Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay. Protein Sci. 2008 Nov;17(11):1971-8. doi: 10.1110/ps.036186.108. Epub 2008 Sep 9. [Article]
  4. Chen J, Zhang L, Zhang Y, Zhang H, Du J, Ding J, Guo Y, Jiang H, Shen X: Emodin targets the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization. BMC Microbiol. 2009 May 12;9:91. doi: 10.1186/1471-2180-9-91. [Article]
  5. He L, Zhang L, Liu X, Li X, Zheng M, Li H, Yu K, Chen K, Shen X, Jiang H, Liu H: Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination. J Med Chem. 2009 Apr 23;52(8):2465-81. doi: 10.1021/jm8015602. [Article]

Associated Data

Bio-Entities
Bio-EntityType
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ (Helicobacter pylori)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]naphthalene-2-carbohydrazideexperimentalunknowntargetDetails
4-chloro-N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]benzohydrazideexperimentalunknowntargetDetails
N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]-4-methoxybenzohydrazideexperimentalunknowntargetDetails
3-bromo-N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]benzohydrazideexperimentalunknowntargetDetails
4-tert-butyl-N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]benzohydrazideexperimentalunknowntargetDetails
4-bromo-N'-[(1E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]benzohydrazideexperimentalunknowntargetDetails
ApigeninexperimentalunknowntargetDetails
EmodininvestigationalunknowntargetDetails
Quercetinexperimental, investigationalunknowntargetDetails
SakuranetinexperimentalunknowntargetDetails