Glycine receptor subunit alpha-4

Details

Name
Glycine receptor subunit alpha-4
Synonyms
Not Available
Gene Name
GLRA4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052086|Glycine receptor subunit alpha-4
MTTLVPATLSFLLLWTLPGQVLLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDA
RIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLD
PSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFP
MDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKHYNTG
KFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTT
QSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSRQHKEFIRLRRRQRRQR
LEEDIIQESRFYFRGYGLGHCLQARDGGPMEGSGIYSPQPPAPLLREGETTRKLYVD
Number of residues
417
Molecular Weight
47727.92
Theoretical pI
Not Available
GO Classification
Functions
extracellularly glycine-gated chloride channel activity / glycine binding / transmembrane signaling receptor activity / transmitter-gated ion channel activity
Processes
chemical synaptic transmission / chloride transmembrane transport / ion transmembrane transport / nervous system process / neuropeptide signaling pathway / regulation of membrane potential / response to amino acid / signal transduction / synaptic transmission, glycinergic
Components
cell junction / chloride channel complex / dendrite / glycinergic synapse / integral component of plasma membrane / integral component of postsynaptic specialization membrane / neuron projection / perikaryon / synapse
General Function
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents.
Specific Function
Extracellularly glycine-gated chloride channel activity
Pfam Domain Function
Transmembrane Regions
258-279 285-305 317-337
Cellular Location
Cell junction
Gene sequence
>lcl|BSEQ0052087|Glycine receptor subunit alpha-4 (GLRA4)
ATGACAACTCTTGTTCCTGCAACCCTCTCCTTCCTTCTTCTCTGGACCCTGCCAGGGCAG
GTCCTCCTCAGGGTGGCCTTGGCAAAAGAGGAAGTCAAATCTGGAACCAAGGGGTCCCAG
CCCATGTCCCCCTCTGATTTCCTAGACAAACTTATGGGGCGAACATCTGGATATGATGCC
AGGATTCGGCCCAATTTTAAAGGCCCACCCGTGAACGTGACCTGCAACATCTTCATCAAC
AGTTTCAGCTCCATCACCAAGACCACAATGGACTACCGGGTGAATGTCTTCTTGCGGCAA
CAGTGGAATGACCCACGCCTGTCCTACCGAGAATATCCTGATGACTCTCTGGACCTCGAT
CCCTCCATGCTGGACTCTATCTGGAAGCCAGACCTCTTCTTTGCTAATGAGAAAGGGGCC
AACTTCCATGAGGTGACCACGGACAACAAGTTACTGCGCATCTTCAAGAATGGGAATGTG
CTGTACAGCATCAGGCTGACCCTCATTTTGTCCTGCCTGATGGACCTCAAGAACTTCCCC
ATGGACATCCAGACCTGCACGATGCAGCTTGAGAGCTTTGGCTACACCATGAAAGACCTC
GTGTTTGAGTGGCTGGAAGATGCTCCTGCTGTCCAAGTGGCTGAGGGGCTGACTCTGCCC
CAGTTTATCTTGCGGGATGAGAAGGATCTAGGCTGTTGTACCAAGCACTACAACACAGGG
AAATTCACCTGCATCGAGGTAAAGTTTCACCTGGAACGGCAGATGGGCTACTATCTGATT
CAGATGTACATCCCCAGCCTACTCATCGTCATCCTGTCCTGGGTCTCCTTCTGGATCAAC
ATGGATGCTGCCCCTGCCCGTGTGGGCCTGGGCATCACCACCGTGCTCACCATGACCACC
CAGAGCTCTGGCTCCCGGGCCTCTTTGCCTAAGGTGTCCTACGTGAAGGCAATCGACATC
TGGATGGCTGTGTGTCTGCTCTTTGTGTTCGCTGCCTTGCTGGAGTATGCTGCCATAAAT
TTTGTTTCTCGTCAGCATAAAGAATTCATACGACTTCGAAGAAGGCAGAGGCGCCAACGC
TTGGAGGAAGATATCATCCAAGAAAGTCGTTTCTATTTCCGTGGCTATGGCTTGGGCCAC
TGCCTGCAGGCAAGAGATGGAGGTCCAATGGAAGGTTCTGGCATTTATAGTCCCCAACCT
CCAGCCCCTCTTCTAAGGGAAGGAGAAACCACGCGGAAACTCTACGTGGACTGA
Chromosome Location
X
Locus
Xq22.2
External Identifiers
ResourceLink
UniProtKB IDQ5JXX5
UniProtKB Entry NameGLRA4_HUMAN
HGNC IDHGNC:31715
General References
  1. Ross MT, Grafham DV, Coffey AJ, Scherer S, McLay K, Muzny D, Platzer M, Howell GR, Burrows C, Bird CP, Frankish A, Lovell FL, Howe KL, Ashurst JL, Fulton RS, Sudbrak R, Wen G, Jones MC, Hurles ME, Andrews TD, Scott CE, Searle S, Ramser J, Whittaker A, Deadman R, Carter NP, Hunt SE, Chen R, Cree A, Gunaratne P, Havlak P, Hodgson A, Metzker ML, Richards S, Scott G, Steffen D, Sodergren E, Wheeler DA, Worley KC, Ainscough R, Ambrose KD, Ansari-Lari MA, Aradhya S, Ashwell RI, Babbage AK, Bagguley CL, Ballabio A, Banerjee R, Barker GE, Barlow KF, Barrett IP, Bates KN, Beare DM, Beasley H, Beasley O, Beck A, Bethel G, Blechschmidt K, Brady N, Bray-Allen S, Bridgeman AM, Brown AJ, Brown MJ, Bonnin D, Bruford EA, Buhay C, Burch P, Burford D, Burgess J, Burrill W, Burton J, Bye JM, Carder C, Carrel L, Chako J, Chapman JC, Chavez D, Chen E, Chen G, Chen Y, Chen Z, Chinault C, Ciccodicola A, Clark SY, Clarke G, Clee CM, Clegg S, Clerc-Blankenburg K, Clifford K, Cobley V, Cole CG, Conquer JS, Corby N, Connor RE, David R, Davies J, Davis C, Davis J, Delgado O, Deshazo D, Dhami P, Ding Y, Dinh H, Dodsworth S, Draper H, Dugan-Rocha S, Dunham A, Dunn M, Durbin KJ, Dutta I, Eades T, Ellwood M, Emery-Cohen A, Errington H, Evans KL, Faulkner L, Francis F, Frankland J, Fraser AE, Galgoczy P, Gilbert J, Gill R, Glockner G, Gregory SG, Gribble S, Griffiths C, Grocock R, Gu Y, Gwilliam R, Hamilton C, Hart EA, Hawes A, Heath PD, Heitmann K, Hennig S, Hernandez J, Hinzmann B, Ho S, Hoffs M, Howden PJ, Huckle EJ, Hume J, Hunt PJ, Hunt AR, Isherwood J, Jacob L, Johnson D, Jones S, de Jong PJ, Joseph SS, Keenan S, Kelly S, Kershaw JK, Khan Z, Kioschis P, Klages S, Knights AJ, Kosiura A, Kovar-Smith C, Laird GK, Langford C, Lawlor S, Leversha M, Lewis L, Liu W, Lloyd C, Lloyd DM, Loulseged H, Loveland JE, Lovell JD, Lozado R, Lu J, Lyne R, Ma J, Maheshwari M, Matthews LH, McDowall J, McLaren S, McMurray A, Meidl P, Meitinger T, Milne S, Miner G, Mistry SL, Morgan M, Morris S, Muller I, Mullikin JC, Nguyen N, Nordsiek G, Nyakatura G, O'Dell CN, Okwuonu G, Palmer S, Pandian R, Parker D, Parrish J, Pasternak S, Patel D, Pearce AV, Pearson DM, Pelan SE, Perez L, Porter KM, Ramsey Y, Reichwald K, Rhodes S, Ridler KA, Schlessinger D, Schueler MG, Sehra HK, Shaw-Smith C, Shen H, Sheridan EM, Shownkeen R, Skuce CD, Smith ML, Sotheran EC, Steingruber HE, Steward CA, Storey R, Swann RM, Swarbreck D, Tabor PE, Taudien S, Taylor T, Teague B, Thomas K, Thorpe A, Timms K, Tracey A, Trevanion S, Tromans AC, d'Urso M, Verduzco D, Villasana D, Waldron L, Wall M, Wang Q, Warren J, Warry GL, Wei X, West A, Whitehead SL, Whiteley MN, Wilkinson JE, Willey DL, Williams G, Williams L, Williamson A, Williamson H, Wilming L, Woodmansey RL, Wray PW, Yen J, Zhang J, Zhou J, Zoghbi H, Zorilla S, Buck D, Reinhardt R, Poustka A, Rosenthal A, Lehrach H, Meindl A, Minx PJ, Hillier LW, Willard HF, Wilson RK, Waterston RH, Rice CM, Vaudin M, Coulson A, Nelson DL, Weinstock G, Sulston JE, Durbin R, Hubbard T, Gibbs RA, Beck S, Rogers J, Bentley DR: The DNA sequence of the human X chromosome. Nature. 2005 Mar 17;434(7031):325-37. [Article]
  2. Yim PD, Gallos G, Xu D, Zhang Y, Emala CW: Novel expression of a functional glycine receptor chloride channel that attenuates contraction in airway smooth muscle. FASEB J. 2011 May;25(5):1706-17. doi: 10.1096/fj.10-170530. Epub 2011 Jan 31. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01043Memantineapproved, investigationalunknowninhibitorDetails