Tyrosine--tRNA ligase

Details

Name

Tyrosine--tRNA ligase

Synonyms

• 6.1.1.1
• Tyrosyl-tRNA synthetase
• TyrRS

Gene Name

YARS

Organism

APMV

Amino acid sequence

>lcl|BSEQ0013041|Tyrosine--tRNA ligase
MENTDHTNNEHRLTQLLSIAEECETLDRLKQLVDSGRIFTAYNGFEPSGRIHIAQALITV
MNTNNIIECGGQMIIYIADWFAKMNLKMNGDINKIRELGRYFIEVFKACGINLDGTRFIW
ASEFIASNPSYIERMLDIAEFSTISRVKRCCQIMGRNESDCLKASQIFYPCMQAADVFEL
VPEGIDICQLGIDQRKVNMLAIEYANDRGLKIPISLSHHMLMSLSGPKKKMSKSDPQGAI
FMDDTEQEVSEKISRAYCTDETFDNPIFEYIKYLLLRWFGTLNLCGKIYTDIESIQEDFS
SMNKRELKTDVANYINTIIDLVREHFKKPELSELLSNVKSYQQPSK

Number of residues

346

Molecular Weight

39722.195

Theoretical pI

5.16

GO Classification

Functions

ATP binding / identical protein binding / tyrosine-tRNA ligase activity

Processes

tRNA aminoacylation for protein translation

General Function

Tyrosine-trna ligase activity

Specific Function

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).

Pfam Domain Function

• tRNA-synt_1b (PF00579)

Transmembrane Regions

Not Available

Cellular Location

Not Available

Gene sequence

>lcl|BSEQ0013042|Tyrosine--tRNA ligase (YARS)
ATGGAAAACACAGACCATACCAATAATGAACATCGTTTGACTCAACTTCTATCAATAGCA
GAAGAATGTGAAACATTAGATCGACTCAAACAATTAGTTGATTCAGGAAGAATTTTTACA
GCTTACAATGGTTTTGAACCTAGTGGTCGTATTCATATTGCTCAAGCTCTTATTACTGTA
ATGAACACCAATAATATTATTGAATGTGGTGGACAGATGATTATCTATATTGCCGATTGG
TTTGCCAAAATGAATTTGAAAATGAATGGAGATATTAATAAGATTAGAGAACTTGGAAGA
TATTTTATTGAAGTTTTCAAAGCATGTGGTATTAATTTGGATGGTACAAGATTTATTTGG
GCCAGTGAATTCATTGCTTCTAATCCATCTTATATCGAGAGAATGTTAGATATAGCTGAA
TTTTCTACTATATCTAGAGTTAAAAGATGTTGTCAAATCATGGGTCGTAATGAAAGTGAT
TGTTTAAAAGCCTCACAAATTTTCTATCCTTGTATGCAAGCTGCAGACGTATTTGAATTA
GTTCCTGAAGGAATTGACATTTGTCAACTAGGAATTGATCAACGTAAAGTCAATATGTTG
GCTATTGAATATGCAAATGACCGTGGATTAAAAATCCCAATTTCTCTATCACATCACATG
TTAATGAGTCTATCTGGTCCAAAAAAAAAAATGAGTAAATCTGATCCTCAAGGTGCAATT
TTTATGGATGATACTGAACAAGAAGTCAGTGAAAAAATATCTAGAGCATATTGTACTGAT
GAAACTTTTGACAATCCAATTTTCGAATACATCAAATATTTGCTTTTGAGATGGTTTGGT
ACATTAAACTTATGTGGTAAAATATACACAGATATCGAGTCAATTCAAGAAGATTTTTCC
AGTATGAATAAACGTGAACTTAAAACTGATGTAGCCAATTATATTAACACTATTATTGAT
CTAGTTAGAGAACACTTCAAAAAACCAGAATTGTCTGAATTGTTATCAAATGTCAAATCT
TACCAACAACCTTCAAAATAA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q5UPJ7
UniProtKB Entry Name	SYY_MIMIV
GenBank Protein ID	55416626
GenBank Gene ID	AY653733

General References

1. Raoult D, Audic S, Robert C, Abergel C, Renesto P, Ogata H, La Scola B, Suzan M, Claverie JM: The 1.2-megabase genome sequence of Mimivirus. Science. 2004 Nov 19;306(5700):1344-50. Epub 2004 Oct 14. [Article]
2. Abergel C, Chenivesse S, Byrne D, Suhre K, Arondel V, Claverie JM: Mimivirus TyrRS: preliminary structural and functional characterization of the first amino-acyl tRNA synthetase found in a virus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Feb 1;61(Pt 2):212-5. Epub 2005 Jan 20. [Article]
3. Abergel C, Rudinger-Thirion J, Giege R, Claverie JM: Virus-encoded aminoacyl-tRNA synthetases: structural and functional characterization of mimivirus TyrRS and MetRS. J Virol. 2007 Nov;81(22):12406-17. Epub 2007 Sep 12. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB03978	Tyrosinal	experimental	unknown		Details