Fiber
Details
- Name
- Fiber
- Synonyms
- Fiber protein
- Gene Name
- L5
- Organism
- Human adenovirus D37
- Amino acid sequence
>lcl|BSEQ0022064|Fiber MSKRLRVEDDFNPVYPYGYARNQNIPFLTPPFVSSDGFKNFPPGVLSLKLADPITITNGD VSLKVGGGLTLQDGSLTVNPKAPLQVNTDKKLELAYDNPFESSANKLSLKVGHGLKVLDE KSAAGLKDLIGKLVVLTGKGIGTENLENTDGSSRGIGINVRAREGLTFDNDGYLVAWNPK YDTRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHIINNKTNPK IKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEKAIGFMPNLVAYPKPSNSK KYARDIVYGTIYLGGKPDQPAVIKTTFNQETGCEYSITFNFSWSKTYENVEFETTSFTFS YIAQE
- Number of residues
- 365
- Molecular Weight
- 40092.19
- Theoretical pI
- 9.35
- GO Classification
- Functionsmetal ion bindingProcessescell adhesion / pathogenesis / virion attachment to host cellComponentsviral capsid
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0006185|1098 bp ATGTCAAAGAGGCTCCGGGTGGAAGATGACTTCAACCCCGTCTACCCCTATGGCTACGCG CGGAATCAGAATATCCCCTTCCTCACTCCCCCCTTTGTCTCCTCCGATGGATTCAAAAAC TTCCCCCCTGGGGTACTGTCACTCAAACTGGCTGATCCAATCACCATTACCAATGGGGAT GTATCCCTCAAGGTGGGAGGTGGTCTCACTTTGCAAGATGGAAGCCTAACTGTAAACCCT AAGGCTCCACTGCAAGTTAATACTGATAAAAAACTTGAGCTTGCATATGATAATCCATTT GAAAGTAGTGCTAATAAACTTAGTTTAAAAGTAGGACATGGATTAAAAGTATTAGATGAA AAAAGTGCTGCGGGGTTAAAAGATTTAATTGGCAAACTTGTGGTTTTAACAGGAAAAGGA ATAGGCACTGAAAATTTAGAAAATACAGATGGTAGCAGCAGAGGAATTGGTATAAATGTA AGAGCAAGAGAAGGGTTGACATTTGACAATGATGGATACTTGGTAGCATGGAACCCAAAG TATGACACGCGCACACTTTGGACAACACCAGACACATCTCCAAACTGCACAATTGCTCAA GATAAGGACTCTAAACTCACTTTGGTACTTACAAAGTGTGGAAGTCAAATATTAGCTAAT GTGTCTTTGATTGTGGTCGCAGGAAAGTACCACATCATAAATAATAAGACAAATCCAAAA ATAAAAAGTTTTACTATTAAACTGCTATTTAATAAGAACGGAGTGCTTTTAGACAACTCA AATCTTGGAAAAGCTTATTGGAACTTTAGAAGTGGAAATTCCAATGTTTCGACAGCTTAT GAAAAAGCAATTGGTTTTATGCCTAATTTGGTAGCGTATCCAAAACCCAGTAATTCTAAA AAATATGCAAGAGACATAGTTTATGGAACTATATATCTTGGTGGAAAACCTGATCAGCCA GCAGTCATTAAAACTACCTTTAACCAAGAAACTGGATGTGAATACTCTATCACATTTAAC TTTAGTTGGTCCAAAACCTATGAAAATGTTGAATTTGAAACCACCTCTTTTACCTTCTCC TATATTGCCCAAGAATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q64823 UniProtKB Entry Name Q64823_9ADEN GenBank Gene ID X94484 - General References
- Burmeister WP, Guilligay D, Cusack S, Wadell G, Arnberg N: Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites. J Virol. 2004 Jul;78(14):7727-36. [Article]
- Johansson S, Nilsson E, Qian W, Guilligay D, Crepin T, Cusack S, Arnberg N, Elofsson M: Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis. J Med Chem. 2009 Jun 25;52(12):3666-78. doi: 10.1021/jm801609s. [Article]
- Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S, Kremer EJ: The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution. PLoS Pathog. 2009 Jan;5(1):e1000277. doi: 10.1371/journal.ppat.1000277. Epub 2009 Jan 2. [Article]
- Spjut S, Qian W, Bauer J, Storm R, Frangsmyr L, Stehle T, Arnberg N, Elofsson M: A potent trivalent sialic acid inhibitor of adenovirus type 37 infection of human corneal cells. Angew Chem Int Ed Engl. 2011 Jul 11;50(29):6519-21. doi: 10.1002/anie.201101559. Epub 2011 Jun 6. [Article]
- Nilsson EC, Storm RJ, Bauer J, Johansson SM, Lookene A, Angstrom J, Hedenstrom M, Eriksson TL, Frangsmyr L, Rinaldi S, Willison HJ, Pedrosa Domellof F, Stehle T, Arnberg N: The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis. Nat Med. 2011 Jan;17(1):105-9. doi: 10.1038/nm.2267. Epub 2010 Dec 12. [Article]
- Caraballo R, Saleeb M, Bauer J, Liaci AM, Chandra N, Storm RJ, Frangsmyr L, Qian W, Stehle T, Arnberg N, Elofsson M: Triazole linker-based trivalent sialic acid inhibitors of adenovirus type 37 infection of human corneal epithelial cells. Org Biomol Chem. 2015 Sep 21;13(35):9194-205. doi: 10.1039/c5ob01025j. Epub 2015 Jul 16. [Article]