Glycine N-acyltransferase
Details
- Name
- Glycine N-acyltransferase
- Synonyms
- 2.3.1.13
- AAc
- ACGNAT
- Acyl-CoA:glycine N-acyltransferase
- Aralkyl acyl-CoA N-acyltransferase
- Aralkyl acyl-CoA:amino acid N-acyltransferase
- Benzoyl-coenzyme A:glycine N-acyltransferase
- CAT
- GAT
- Glycine N-benzoyltransferase
- HRP-1(CLP)
- Gene Name
- GLYAT
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037188|Glycine N-acyltransferase MMLPLQGAQMLQMLEKSLRKSLPASLKVYGTVFHINHGNPFNLKAVVDKWPDFNTVVVCP QEQDMTDDLDHYTNTYQIYSKDPQNCQEFLGSPELINWKQHLQIQSSQPSLNEAIQNLAA IKSFKVKQTQRILYMAAETAKELTPFLLKSKILSPNGGKPKAINQEMFKLSSMDVTHAHL VNKFWHFGGNERSQRFIERCIQTFPTCCLLGPEGTPVCWDLMDQTGEMRMAGTLPEYRLH GLVTYVIYSHAQKLGKLGFPVYSHVDYSNEAMQKMSYTLQHVPIPRSWNQWNCVPL
- Number of residues
- 296
- Molecular Weight
- 33923.995
- Theoretical pI
- 8.28
- GO Classification
- Functionsglycine N-acyltransferase activity / glycine N-benzoyltransferase activity / transferase activity, transferring acyl groupsProcessesacyl-CoA metabolic process / glycine metabolic process / monocarboxylic acid metabolic process / response to toxic substance / small molecule metabolic process / xenobiotic metabolic processComponentsextracellular exosome / mitochondrial matrix / mitochondrion
- General Function
- Transferase activity, transferring acyl groups
- Specific Function
- Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion
- Gene sequence
>lcl|BSEQ0011661|Glycine N-acyltransferase (GLYAT) ATGATGTTACCATTGCAAGGTGCCCAGATGCTGCAGATGCTGGAGAAATCCTTGAGGAAG AGCCTCCCAGCATCCTTAAAGGTTTATGGAACTGTCTTTCACATAAACCATGGAAATCCA TTCAATCTGAAGGCTGTGGTGGACAAGTGGCCTGATTTTAATACAGTGGTTGTCTGCCCT CAGGAGCAGGATATGACAGATGACCTTGATCACTATACCAATACTTACCAAATCTACTCC AAAGATCCCCAAAACTGTCAGGAATTCCTTGGATCACCAGAACTCATCAACTGGAAACAG CATTTACAGATTCAAAGTTCACAGCCTAGCCTGAATGAGGCTATACAAAATCTTGCAGCC ATTAAGTCCTTCAAAGTCAAACAAACACAACGCATTCTCTATATGGCAGCTGAAACAGCC AAGGAACTGACTCCTTTCCTGCTGAAATCAAAGATTTTATCTCCCAATGGTGGCAAACCC AAGGCCATGTGA
- Chromosome Location
- 11
- Locus
- 11q12.1
- External Identifiers
Resource Link UniProtKB ID Q6IB77 UniProtKB Entry Name GLYAT_HUMAN GenBank Protein ID 2554941 GenBank Gene ID AF023466 GenAtlas ID GLYAT HGNC ID HGNC:13734 - General References
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