Ornithine aminotransferase

Details

Name
Ornithine aminotransferase
Synonyms
  • 2.6.1.13
  • Ornithine--oxo-acid aminotransferase
Gene Name
OAT
Organism
Plasmodium falciparum (isolate 3D7)
Amino acid sequence
>lcl|BSEQ0051352|Ornithine aminotransferase
MDFVKELKSSQDYMNNELTYGAHNYDPIPVVLKRGKGVFVYDIEDRRYYDFLSAYSSVNQ
GHCHPDILNAMINQAKKLTICSRAFFSDSLGVCERYLTNLFGYDKVLMMNTGAEASETAY
KLCRKWGYEVKKIPENSAKIIVCNNNFSGRTLGCVSASTDKKCKNNFGPFVPNFLKVPYD
DLEALEKELQDPNVCAFIVEPVQGEAGVIVPSDSYFPGVASLCKKYNVLFVADEVQTGLG
RTGKLLCTHHYGVKPDVILLGKALSGGHYPISAILANDDVMLVLKPGEHGSTYGGNPLAA
AICVEALKVLINEKLCENADKLGAPFLQNLKEQLKDSKVVREVRGKGLLCAIEFKNDLVN
VWDICLKFKENGLITRSVHDKTVRLTPPLCITKEQLDECTEIIVKTVKFFDDNL
Number of residues
414
Molecular Weight
46054.755
Theoretical pI
Not Available
GO Classification
Functions
identical protein binding / ornithine-oxo-acid transaminase activity / pyridoxal phosphate binding
Processes
L-proline biosynthetic process / ornithine metabolic process
Components
cytoplasm
General Function
The enzyme has a very narrow substrate specificity and can only catalyze the transamination of alpha-ketoglutarate with ornithine or N-acetylornithine and of glutamate-5-semialdehyde with glutamate and alanine.
Specific Function
Identical protein binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051353|Ornithine aminotransferase (OAT)
ATGGATTTCGTTAAAGAATTAAAAAGTAGTCAAGATTACATGAACAACGAATTAACCTAT
GGAGCTCACAACTATGACCCAATTCCAGTTGTTTTAAAGAGAGGTAAAGGTGTTTTCGTT
TACGATATTGAAGATAGGAGATATTACGACTTTTTATCTGCTTACTCATCAGTTAACCAA
GGACACTGCCACCCAGATATATTAAATGCTATGATCAACCAAGCAAAAAAATTAACCATT
TGCAGTAGAGCATTTTTCAGTGACTCATTAGGAGTATGTGAAAGATACCTTACTAATTTA
TTTGGTTATGACAAAGTATTAATGATGAACACTGGTGCTGAAGCTAGTGAAACCGCTTAC
AAATTATGTAGAAAATGGGGTTATGAAGTAAAAAAAATCCCAGAAAACTCAGCAAAAATT
ATTGTTTGTAACAATAACTTCTCTGGAAGAACCTTAGGTTGTGTATCAGCTTCCACTGAT
AAGAAATGCAAAAACAACTTTGGTCCATTCGTACCAAACTTCCTTAAAGTTCCATATGAT
GATTTAGAAGCTTTAGAAAAAGAATTACAAGACCCAAATGTCTGTGCCTTTATTGTTGAA
CCAGTACAAGGAGAAGCTGGTGTTATAGTACCATCAGATAGTTATTTCCCAGGTGTAGCT
TCCTTATGTAAGAAATACAATGTATTATTCGTAGCAGATGAAGTACAAACAGGTTTAGGA
AGAACCGGAAAATTATTATGTACTCACCACTATGGAGTAAAACCAGATGTCATCCTTTTA
GGAAAGGCTCTTTCTGGAGGTCACTACCCAATATCAGCTATATTAGCAAATGATGATGTT
ATGCTTGTATTGAAACCAGGAGAACACGGTTCAACCTATGGTGGTAACCCATTAGCTGCT
GCTATTTGCGTAGAAGCTTTAAAAGTTTTGATAAACGAAAAATTATGTGAAAATGCTGAT
AAATTAGGTGCTCCATTCTTACAAAATCTTAAAGAACAATTAAAAGACAGCAAAGTTGTT
CGTGAAGTAAGAGGAAAAGGTTTATTATGTGCCATTGAATTTAAAAACGACCTTGTCAAC
GTATGGGATATCTGCTTGAAATTTAAAGAAAACGGACTTATCACCAGATCTGTTCATGAC
AAAACAGTTCGTTTAACACCACCATTATGTATAACCAAAGAACAATTAGATGAATGTACT
GAAATTATTGTAAAAACTGTTAAATTTTTTGATGACAATTTATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ6LFH8
UniProtKB Entry NameOAT_PLAF7
General References
  1. Gafan C, Wilson J, Berger LC, Berger BJ: Characterization of the ornithine aminotransferase from Plasmodium falciparum. Mol Biochem Parasitol. 2001 Nov;118(1):1-10. [Article]
  2. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. [Article]
  3. Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG: Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature. 2002 Oct 3;419(6906):527-31. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails