Zinc transporter ZIP4
Details
- Name
- Zinc transporter ZIP4
- Synonyms
- Solute carrier family 39 member 4
- ZIP-4
- ZIP4
- Zrt- and Irt-like protein 4
- Gene Name
- SLC39A4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052351|Zinc transporter ZIP4 MASLVSLELGLLLAVLVVTATASPPAGLLSLLTSGQGALDQEALGGLLNTLADRVHCANG PCGKCLSVEDALGLGEPEGSGLPPGPVLEARYVARLSAAAVLYLSNPEGTCEDARAGLWA SHADHLLALLESPKALTPGLSWLLQRMQARAAGQTPKMACVDIPQLLEEAVGAGAPGSAG GVLAALLDHVRSGSCFHALPSPQYFVDFVFQQHSSEVPMTLAELSALMQRLGVGREAHSD HSHRHRGASSRDPVPLISSSNSSSVWDTVCLSARDVMAAYGLSEQAGVTPEAWAQLSPAL LQQQLSGACTSQSRPPVQDQLSQSERYLYGSLATLLICLCAVFGLLLLTCTGCRGVTHYI LQTFLSLAVGAVTGDAVLHLTPKVLGLHTHSEEGLSPQPTWRLLAMLAGLYAFFLFENLF NLLLPRDPEDLEDGPCGHSSHSHGGHSHGVSLQLAPSELRQPKPPHEGSRADLVAEESPE LLNPEPRRLSPELRLLPYMITLGDAVHNFADGLAVGAAFASSWKTGLATSLAVFCHELPH ELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALAVGVSEESEAWILAVATGLFLYV ALCDMLPAMLKVRDPRPWLLFLLHNVGLLGGWTVLLLLSLYEDDITF
- Number of residues
- 647
- Molecular Weight
- 68406.75
- Theoretical pI
- Not Available
- GO Classification
- Functionszinc ion transmembrane transporter activityProcessescellular response to zinc ion starvation / cellular zinc ion homeostasis / signal transduction / zinc ion import across plasma membraneComponentsapical plasma membrane / cell / cytoplasmic vesicle / integral component of plasma membrane / plasma membrane / recycling endosome membrane
- General Function
- Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity).
- Specific Function
- Zinc ion transmembrane transporter activity
- Pfam Domain Function
- Transmembrane Regions
- 328-348 360-380 403-423 559-579 587-607 618-638
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052352|Zinc transporter ZIP4 (SLC39A4) ATGGCGTCCCTGGTCTCGCTGGAGCTGGGGCTGCTTCTGGCTGTGCTGGTGGTGACGGCG ACGGCGTCCCCGCCTGCTGGTCTGCTGAGCCTGCTCACCTCTGGCCAGGGCGCTCTGGAT CAAGAGGCTCTGGGCGGCCTGTTAAATACGCTGGCGGACCGTGTGCACTGCGCCAACGGG CCGTGTGGAAAGTGCCTGTCTGTGGAGGACGCCCTGGGCCTGGGCGAGCCTGAGGGGTCA GGGCTGCCCCCGGGCCCGGTCCTGGAGGCCAGGTACGTCGCCCGCCTCAGTGCCGCCGCC GTCCTGTACCTCAGCAACCCCGAGGGCACCTGTGAGGACGCTCGGGCTGGCCTCTGGGCC TCTCATGCAGACCACCTCCTGGCCCTGCTCGAGAGCCCCAAGGCCCTGACCCCGGGCCTG AGCTGGCTGCTGCAGAGGATGCAGGCCCGGGCTGCCGGCCAGACCCCCAAGATGGCCTGC GTAGATATCCCTCAGCTGCTGGAGGAGGCGGTGGGGGCGGGGGCTCCGGGCAGTGCTGGC GGCGTCCTGGCTGCCCTGCTGGACCATGTCAGGAGCGGGTCTTGCTTCCACGCCTTGCCG AGCCCTCAGTACTTCGTGGACTTTGTGTTCCAGCAGCACAGCAGCGAGGTCCCTATGACG CTGGCCGAGCTGTCAGCCTTGATGCAGCGCCTGGGGGTGGGCAGGGAGGCCCACAGTGAC CACAGTCATCGGCACAGGGGAGCCAGCAGCCGGGACCCTGTGCCCCTCATCAGCTCCAGC AACAGCTCCAGTGTGTGGGACACGGTATGCCTGAGTGCCAGGGACGTGATGGCTGCATAT GGACTGTCGGAACAGGCTGGGGTGACCCCGGAGGCCTGGGCCCAACTGAGCCCTGCCCTG CTCCAACAGCAGCTGAGTGGAGCCTGCACCTCCCAGTCCAGGCCCCCCGTCCAGGACCAG CTCAGCCAGTCAGAGAGGTATCTGTACGGCTCCCTGGCCACGCTGCTCATCTGCCTCTGC GCGGTCTTTGGCCTCCTGCTGCTGACCTGCACTGGCTGCAGGGGGGTCACCCACTACATC CTGCAGACCTTCCTGAGCCTGGCAGTGGGTGCAGTCACTGGGGACGCTGTCCTGCATCTG ACGCCCAAGGTGCTGGGGCTGCATACACACAGCGAAGAGGGCCTCAGCCCACAGCCCACC TGGCGCCTCCTGGCTATGCTGGCCGGGCTCTACGCCTTCTTCCTGTTTGAGAACCTCTTC AATCTCCTGCTGCCCAGGGACCCGGAGGACCTGGAGGACGGGCCCTGCGGCCACAGCAGC CATAGCCACGGGGGCCACAGCCACGGTGTGTCCCTGCAGCTGGCACCCAGCGAGCTCCGG CAGCCCAAGCCCCCCCACGAGGGCTCCCGCGCAGACCTGGTGGCGGAGGAGAGCCCGGAG CTGCTGAACCCTGAGCCCAGGAGACTGAGCCCAGAGTTGAGGCTACTGCCCTATATGATC ACTCTGGGCGACGCCGTGCACAACTTCGCCGACGGGCTGGCCGTGGGCGCCGCCTTCGCG TCCTCCTGGAAGACCGGGCTGGCCACCTCGCTGGCCGTGTTCTGCCACGAGTTGCCACAC GAGCTGGGGGACTTCGCCGCCTTGCTGCACGCGGGGCTGTCCGTGCGCCAAGCACTGCTG CTGAACCTGGCCTCCGCGCTCACGGCCTTCGCTGGTCTCTACGTGGCACTCGCGGTTGGA GTCAGCGAGGAGAGCGAGGCCTGGATCCTGGCAGTGGCCACCGGCCTGTTCCTCTACGTA GCACTCTGCGACATGCTCCCGGCGATGTTGAAAGTACGGGACCCGCGGCCCTGGCTCCTC TTCCTGCTGCACAACGTGGGCCTGCTGGGCGGCTGGACCGTCCTGCTGCTGCTGTCCCTG TACGAGGATGACATCACCTTCTGA
- Chromosome Location
- 8
- Locus
- 8q24.3
- External Identifiers
Resource Link UniProtKB ID Q6P5W5 UniProtKB Entry Name S39A4_HUMAN HGNC ID HGNC:17129 - General References
- Kury S, Dreno B, Bezieau S, Giraudet S, Kharfi M, Kamoun R, Moisan JP: Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. Nat Genet. 2002 Jul;31(3):239-40. doi: 10.1038/ng913. Epub 2002 Jun 17. [Article]
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- Wang K, Zhou B, Kuo YM, Zemansky J, Gitschier J: A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am J Hum Genet. 2002 Jul;71(1):66-73. doi: 10.1086/341125. Epub 2002 May 24. [Article]
- Kim BE, Wang F, Dufner-Beattie J, Andrews GK, Eide DJ, Petris MJ: Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. J Biol Chem. 2004 Feb 6;279(6):4523-30. doi: 10.1074/jbc.M310799200. Epub 2003 Nov 11. [Article]
- Nakano A, Nakano H, Nomura K, Toyomaki Y, Hanada K: Novel SLC39A4 mutations in acrodermatitis enteropathica. J Invest Dermatol. 2003 Jun;120(6):963-6. doi: 10.1046/j.1523-1747.2003.12243.x. [Article]