V-type proton ATPase catalytic subunit A
Details
- Name
- V-type proton ATPase catalytic subunit A
- Synonyms
- 3.6.3.14
- V-ATPase 69 kDa subunit
- V-ATPase subunit A
- Vacuolar proton pump subunit alpha
- Gene Name
- vapA
- Organism
- Plasmodium falciparum (isolate 3D7)
- Amino acid sequence
>lcl|BSEQ0051413|V-type proton ATPase catalytic subunit A MTKVAVEKEEPGVVYKVAGSLVIAENMSGTRMYELAKVGWNKLVGEIIRLEGNYAYIQVY EDTSGLSVGDPVIKTGNALSVELGPGILDNIYDGIQRPLERIANVCGDVYIYKGIDMTSL DHDKQWQFYADKKLKLNDIVTGGDIFGFVDENKLFKEHKIMAPPNAKGRLTYIAPDGSYT LKDKIFELEYQGKKYTYGLSHLWPVRDPRPVLEKVTGDTLLLTGQRVLDSLFPTVQGGTC AIPGAFGCGKTCVSQALSKYSNSEVIIYVGCGERGNEMAEILSDFPELTTKVDNEDVGIM QRTCLVANTSNMPVAAREASIYTGITLCEYFRDMGYNATMMADSTSRWAEALREISGRLA EMPADSGYPAYLGARLASFYERAGKVKCIGSPSRIGSITIVGAVSPPGGDFSDPVTTATM SIVQAFWGLDKKLAQRKHFPSVNWSTSFSKYVRQLEQYFDNFDQDFLSLRQKISDILQQE SDLNDIVQLVGKDSLSEDQKVVMEVAKIIREDFLQQNAFSDYDYMCPLQKTVGMMRIICH FYAQCLRTLQEYDSRERKIGWGSIYNTLRPTINKITHMKFENPKNSDEYFKKYFKALEEE ITVGLRNLMEK
- Number of residues
- 611
- Molecular Weight
- 68575.81
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / proton-transporting ATPase activity, rotational mechanismProcessesATP hydrolysis coupled proton transport / ATP metabolic process / vacuolar acidificationComponentsfood vacuole / plasma membrane / vacuolar membrane / vacuolar proton-transporting V-type ATPase, V1 domain
- General Function
- Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051414|V-type proton ATPase catalytic subunit A (vapA) ATGACAAAAGTTGCTGTTGAAAAAGAGGAACCAGGAGTTGTTTATAAGGTGGCTGGTTCA TTAGTTATTGCTGAGAATATGAGTGGAACTCGTATGTACGAGTTAGCTAAAGTAGGATGG AATAAATTGGTTGGAGAAATTATTAGATTAGAAGGGAATTATGCATATATACAAGTTTAT GAAGATACTTCAGGTTTATCTGTAGGAGACCCTGTTATAAAAACAGGAAATGCTTTATCA GTCGAATTGGGTCCTGGTATTTTAGATAATATTTATGATGGTATTCAAAGACCATTAGAA AGAATAGCAAATGTGTGTGGTGATGTATATATATATAAAGGTATTGATATGACATCTTTA GATCATGATAAACAATGGCAATTTTATGCTGATAAGAAATTAAAATTAAATGATATTGTT ACTGGTGGAGATATCTTTGGATTTGTTGATGAAAATAAATTATTTAAAGAACACAAAATT ATGGCTCCACCTAATGCTAAAGGGAGGCTTACATATATTGCTCCAGATGGATCATATACT TTAAAAGATAAAATATTTGAATTAGAATATCAAGGAAAAAAATATACATATGGTTTATCT CATTTATGGCCTGTTCGTGATCCTAGACCTGTTTTAGAAAAGGTAACAGGGGATACTTTA TTATTAACAGGGCAAAGAGTTTTAGATTCGTTATTTCCAACAGTTCAAGGAGGTACTTGT GCTATTCCTGGTGCATTTGGTTGTGGAAAAACTTGTGTTTCTCAGGCCTTATCAAAATAT TCTAATAGTGAAGTTATTATATATGTAGGATGTGGTGAAAGAGGTAATGAAATGGCTGAA ATTTTATCCGACTTTCCTGAATTAACTACTAAAGTAGATAATGAAGATGTAGGTATTATG CAAAGAACGTGTTTAGTTGCTAATACTTCTAACATGCCTGTCGCTGCAAGAGAAGCTAGT ATTTATACAGGTATTACTTTATGTGAATATTTCCGTGATATGGGTTATAATGCTACCATG ATGGCTGATAGTACAAGTAGATGGGCAGAAGCCTTAAGAGAAATTTCAGGACGTTTAGCT GAAATGCCTGCAGATAGTGGTTATCCAGCTTATTTAGGTGCTAGATTAGCTTCCTTTTAT GAACGTGCAGGAAAAGTCAAATGTATTGGTTCTCCATCTCGTATAGGATCCATTACAATT GTGGGTGCTGTGTCTCCACCAGGTGGTGATTTCTCTGACCCTGTAACTACAGCAACCATG TCTATTGTTCAAGCATTTTGGGGGTTAGATAAAAAACTAGCTCAAAGAAAACATTTCCCT TCTGTTAATTGGTCTACATCCTTTTCAAAGTATGTCAGACAATTAGAACAATACTTTGAT AATTTTGATCAAGATTTCTTATCTTTAAGACAAAAAATTAGTGATATTTTACAACAAGAA AGTGACTTGAATGATATTGTTCAACTAGTAGGAAAGGATTCATTATCAGAAGACCAAAAA GTTGTTATGGAAGTAGCCAAAATTATTAGAGAAGATTTTCTTCAACAAAATGCATTTAGC GATTATGATTATATGTGCCCATTACAAAAAACAGTTGGTATGATGAGAATTATTTGCCAC TTTTATGCTCAATGCTTAAGAACATTACAAGAATATGACTCAAGAGAAAGAAAAATTGGT TGGGGATCTATATATAATACATTAAGACCAACTATAAATAAAATTACACATATGAAATTT GAAAACCCAAAAAATTCAGATGAATATTTCAAAAAGTATTTTAAGGCACTTGAAGAAGAA ATAACAGTAGGTTTAAGAAACTTGATGGAAAAATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q76NM6 UniProtKB Entry Name VATA_PLAF7 - General References
- Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. [Article]
- Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG: Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature. 2002 Oct 3;419(6906):527-31. [Article]
- Villard V, Agak GW, Frank G, Jafarshad A, Servis C, Nebie I, Sirima SB, Felger I, Arevalo-Herrera M, Herrera S, Heitz F, Backer V, Druilhe P, Kajava AV, Corradin G: Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif. PLoS One. 2007 Jul 25;2(7):e645. [Article]