Response regulator RamR

Details

Name
Response regulator RamR
Synonyms
  • Transcriptional activator RamR
Gene Name
ramR
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Amino acid sequence
>lcl|BSEQ0052784|Response regulator RamR
MGEMVRIAVVHDEKLLRSALVQLLRSDDTLDVSSHCLDADGPELSAALPADVCVVDGECL
TGPEDAGAGRLRARYGDRLVVLATAKRPGVLRRAFDGGALGLVDKNAPAHRLITAVHTVA
RGERFLDETLTVALLKGAEMPLTTRELGVLTLASQGAPIAEIAARLHLSRGTVRNYMATA
VRKVGARNRVDAIRIVQSAGWT
Number of residues
202
Molecular Weight
21489.545
Theoretical pI
Not Available
GO Classification
Functions
DNA binding
Processes
regulation of transcription, DNA-templated
General Function
A transcription factor required for aerial hyphae formation on rich medium (PubMed:12100547, PubMed:12453210). Activates transcription of ramC. Might be part of a two-component regulatory system (PubMed:12453210). Binds the promoter of ramC (PubMed:12100547, PubMed:12453210). Non-phosphorylated protein cooperatively binds multiple sites in the ramC promoter. Has not been seen to autophosphorylate using the small molecule phosphodonors phosphoramidate, acetyl phosphate or carbamoyl phosphate (PubMed:16051268). Upon low expression suppresses the bald (bld, no aerial hyphae) phenotype of citA but not bldJ mutants; higher expression also suppresses the bldJ mutant as well as several other bld mutations, inducing SapB production even on media where SapB is normally not produced (PubMed:12453210). Expression of the ram locus (ramA, ramB and ramR) induces rapid aerial mycelium formation in S.lividans (PubMed:8206859). Overexpression suppresses the no aerial hyphae phenotype of a chaplin-negative strain, probably by inducing expression of SapB (PubMed:17462011). Overexpression of RamR show there are about 280 genes having at least a threefold increase or fourfold decrease in RNA abundance versus wild-type including gene cluster SCO4072-SCO4075 (PubMed:16925552).
Specific Function
Dna binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0052785|Response regulator RamR (ramR)
GTGGGGGAGATGGTTCGTATTGCCGTGGTGCACGACGAGAAGCTGCTGCGGTCGGCACTG
GTGCAACTGCTCAGATCCGACGACACGCTGGACGTGTCCTCGCACTGCCTCGACGCCGAC
GGTCCGGAGCTGAGTGCGGCATTGCCCGCCGACGTCTGTGTCGTGGACGGAGAGTGCCTG
ACGGGGCCGGAAGACGCGGGAGCCGGACGCCTGCGGGCCCGGTACGGGGACCGGCTCGTG
GTCCTCGCGACCGCCAAGCGGCCGGGAGTGCTGCGCCGGGCGTTCGACGGGGGCGCCCTC
GGGCTGGTCGACAAGAACGCCCCGGCCCACCGGCTGATCACCGCCGTGCACACGGTCGCC
CGGGGCGAACGCTTCCTGGACGAGACGCTCACCGTGGCCCTGCTGAAGGGTGCGGAGATG
CCGCTGACCACGAGGGAACTGGGCGTGCTGACCCTGGCTTCCCAGGGGGCGCCGATCGCC
GAGATCGCGGCGCGCCTGCACCTGTCCCGGGGGACGGTCCGCAACTACATGGCCACGGCG
GTCCGGAAGGTGGGTGCCCGCAACCGCGTCGACGCGATCCGCATCGTGCAGAGCGCCGGC
TGGACCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ7AKE4
UniProtKB Entry NameRAMR_STRCO
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04209Dequaliniumapproved, investigationalunknownregulatorDetails