Penicillin-binding protein 1b
Details
- Name
- Penicillin-binding protein 1b
- Synonyms
- Not Available
- Gene Name
- pbp1b
- UniProtKB Entry
- Q7CRA4TrEMBL
- Organism
- Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
- NCBI Taxonomy ID
- 171101
- Amino acid sequence
>lcl|BSEQ0022105|Penicillin-binding protein 1b MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKSAIFPAILLSIKALFNL LFVLGFLGGMLGAGIALGYGVALFDKVRVPQTEELVNQVKDISSISEITYSDGTVIASIE SDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAVIRATLGKFVGLGSSSGGSTL TQQLIKQQVVGDAPTLARKAAEIVDALALERAMNKDEILTTYLNVAPFGRNNKGQNIAGA RQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPYENTGELKSDEDLEIGLRRAKAVLY SMYRTGALSKDEYSQYKDYDLKQDFLPSGTVTGISRDYLYFTTLAEAQERMYDYLAQRDN VSAKELKNEATQKFYRDLAAKEIENGGYKITTTIDQKIHSAMQSAVADYGYLLDDGTGRV EVGNVLMDNQTGAILGFVGGRNYQENQNNHAFDTKRSPASTTKPLLAYGIAIDQGLMGSE TILSNYPTNFANGNPIMYANSKGTGMMTLGEALNYSWNIPAYWTYRMLRENGVDVKGYME KMGYEIPEYGIESLPMGGGIEVTVAQHTNGYQTLANNGVYHQKHVISKIEAADGRVVYEY QDKPVQVYSKATATIMQGLLREVLSSRVTTTFKSNLTSLNPTLANADWIGKTGTTNQDEN MWLMLSTPRLTLGGWIGHDDNHSLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALD PSVVKSEVLKSTGQKPGKVSVEGKEVEVTGSTVTSYWANKSGAPATSYRFAIGGSDADYQ NAWSSIVGSLPTPSSSSSSSSSSSDSSNSSTTRPSSSRARR
- Number of residues
- 821
- Molecular Weight
- 89479.92
- Theoretical pI
- 8.82
- GO Classification
- Functionspenicillin binding / peptidoglycan glycosyltransferase activity / transferase activity, transferring acyl groupsComponentsintegral component of membrane
- General Function
- Not Available
- Specific Function
- acyltransferase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 60-84
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0022106|Penicillin-binding protein 1b (pbp1b) ATGCAAAATCAATTAAATGAATTAAAACGAAAAATGCTGGAATTTTTCCAGCAAAAACAA AAAAATAAAAAATCAGCTAGACCTGGCAAGAAAGGTTCAAGTACCAAAAAATCTAAAACC TTAGATAAGTCAGCCATTTTCCCAGCTATTTTACTGAGTATAAAAGCCTTATTTAACTTA CTCTTTGTACTCGGTTTTCTAGGAGGAATGTTGGGAGCTGGGATTGCTTTGGGGTACGGA GTGGCCTTATTTGACAAGGTTCGGGTGCCTCAGACAGAAGAATTGGTGAATCAGGTCAAG GACATCTCTTCTATTTCAGAGATTACCTATTCGGACGGGACGGTGATTGCTTCCATAGAG AGTGATTTGTTGCGCACTTCTATCTCATCTGAGCAAATTTCGGAAAATCTGAAGAAGGCT ATCATTGCGACAGAAGATGAACACTTTAAAGAACATAAGGGTGTAGTACCCAAGGCGGTG ATTCGTGCGACCTTGGGGAAATTTGTAGGTTTGGGTTCCTCTAGTGGGGGTTCAACCTTG ACCCAGCAACTAATTAAACAGCAGGTGGTTGGGGATGCGCCGACCTTGGCTCGTAAGGCG GCAGAGATTGTGGATGCTCTTGCCTTGGAACGCGCCATGAATAAAGATGAGATTTTAACG ACCTATCTCAATGTGGCTCCCTTTGGCCGAAATAATAAGGGACAGAATATTGCAGGGGCT CGGCAAGCAGCTGAGGGAATTTTCGGTGTAGATGCCAGTCAGTTGACTGTTCCTCAAGCA GCATTTTTAGCAGGACTTCCACAGAGTCCCATTACTTACTCTCCTTATGAAAATACTGGG GAGTTGAAGAGTGATGAAGACCTAGAAATTGGCTTAAGACGGGCTAAGGCAGTTCTTTAC AGTATGTATCGTACAGGTGCATTAAGCAAAGACGAGTATTCTCAGTACAAGGATTATGAC CTTAAACAGGACTTTTTACCATCGGGCACGGTTACAGGAATTTCACGAGACTATTTATAC TTTACAACTTTGGCAGAAGCTCAAGAACGTATGTATGACTATCTAGCTCAGAGAGACAAT GTCTCCGCTAAGGAGTTGAAAAATGAGGCAACTCAGAAGTTTTATCGAGATTTGGCAGCC AAGGAAATTGAAAATGGTGGTTATAAGATTACTACTACCATAGATCAGAAAATTCATTCT GCCATGCAAAGTGCGGTTGCTGATTATGGCTATCTTTTAGACGATGGAACAGGTCGTGTA GAAGTAGGGAATGTCTTGATGGACAACCAAACAGGTGCTATTCTAGGCTTTGTAGGTGGT CGTAATTATCAAGAAAATCAAAATAATCATGCCTTTGATACCAAACGTTCGCCAGCTTCT ACTACCAAGCCCTTGCTGGCCTACGGTATTGCTATTGACCAGGGCTTGATGGGAAGTGAA ACGATTCTATCTAACTATCCAACAAACTTTGCTAATGGCAATCCGATTATGTATGCTAAT AGCAAGGGAACAGGAATGATGACCTTGGGAGAAGCTCTGAACTACTCATGGAATATCCCT GCTTACTGGACCTATCGTATGCTCCGTGAAAATGGTGTTGATGTCAAGGGTTATATGGAA AAGATGGGTTACGAGATTCCTGAGTACGGTATTGAGAGCTTGCCAATGGGTGGTGGTATT GAAGTCACAGTTGCCCAGCATACCAATGGCTATCAGACCTTAGCTAATAATGGAGTTTAT CATCAGAAGCATGTGATTTCAAAGATTGAAGCAGCAGATGGTAGAGTGGTGTATGAGTAT CAGGATAAACCGGTTCAAGTCTATTCAAAAGCTACTGCGACGATTATGCAGGGATTGCTA CGAGAAGTTCTATCCTCTCGTGTGACAACAACCTTCAAGTCTAACCTGACTTCTTTAAAT CCTACTCTGGCTAATGCAGATTGGATTGGGAAGACTGGTACAACCAACCAAGACGAAAAT ATGTGGCTCATGCTTTCGACACCTAGATTAACCCTAGGTGGCTGGATTGGGCATGATGAT AATCATTCATTGTCACGTAGAGCAGGTTATTCTAATAACTCTAATTACATGGCTCATCTG GTAAATGCGATTCAGCAAGCTTCCCCAAGCATTTGGGGGAACGAGCGCTTTGCTTTAGAT CCTAGTGTAGTGAAATCGGAAGTCTTGAAATCAACAGGTCAAAAACCAGGGAAGGTTTCT GTTGAAGGAAAAGAGGTAGAGGTCACAGGTTCGACTGTTACCAGCTATTGGGCTAATAAG TCAGGAGCGCCAGCGACAAGTTATCGCTTTGCTATTGGCGGAAGTGATGCGGATTATCAG AATGCTTGGTCTAGTATTGTGGGGAGTCTACCAACTCCATCCAGCTCCAGCAGTTCAAGT AGTAGTTCTAGCGATAGCAGTAACTCAAGTACTACACGACCTTCTTCTTCAAGGGCGAGA CGATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q7CRA4 UniProtKB Entry Name Q7CRA4_STRR6 GenBank Protein ID 15457529 GenBank Gene ID AE007317 PDB ID(s) 2UWX, 2XD1, 2XD5, 2Y2G, 2Y2H, 2Y2I, 2Y2J, 2Y2K, 2Y2L, 2Y2M, 2Y2N, 2Y2O, 2Y2P, 2Y2Q KEGG ID spr:spr1909 NCBI Gene ID 934893 - General References
- Hoskins J, Alborn WE Jr, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR Jr, Skatrud PL, Glass JI: Genome of the bacterium Streptococcus pneumoniae strain R6. J Bacteriol. 2001 Oct;183(19):5709-17. [Article]
- Macheboeuf P, Di Guilmi AM, Job V, Vernet T, Dideberg O, Dessen A: Active site restructuring regulates ligand recognition in class A penicillin-binding proteins. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):577-82. Epub 2005 Jan 6. [Article]
- Contreras-Martel C, Amoroso A, Woon EC, Zervosen A, Inglis S, Martins A, Verlaine O, Rydzik AM, Job V, Luxen A, Joris B, Schofield CJ, Dessen A: Structure-guided design of cell wall biosynthesis inhibitors that overcome beta-lactam resistance in Staphylococcus aureus (MRSA). ACS Chem Biol. 2011 Sep 16;6(9):943-51. doi: 10.1021/cb2001846. Epub 2011 Aug 3. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Penicillin-binding protein 1b (Streptococcus pneumoniae (strain ATCC BAA-255 / R6)) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details N-BENZOYL-D-ALANINE experimental unknown target Details Cefadroxil approved, vet_approved, withdrawn yes target inhibitor Details Cefotaxime approved yes target inhibitor Details Piperacillin approved yes target inhibitor Details Nafcillin approved, investigational yes target inhibitor Details Ampicillin approved, vet_approved yes target inhibitor Details Dicloxacillin approved, investigational, vet_approved yes target inhibitor Details Amdinocillin investigational, withdrawn yes target inhibitor Details Meticillin approved, investigational yes target inhibitor Details Cefalotin approved, investigational, vet_approved yes target inhibitor Details Oxacillin approved, investigational yes target inhibitor Details Cefoxitin approved yes target inhibitor Details Cephalexin approved, investigational, vet_approved yes target inhibitor Details Cephalosporin C experimental yes target inhibitor Details Azidocillin experimental yes target inhibitor Details Hetacillin approved, vet_approved, withdrawn yes target inhibitor Details