Penicillin-binding protein 1b
Details
- Name
- Penicillin-binding protein 1b
- Synonyms
- Not Available
- Gene Name
- pbp1b
- Organism
- Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
- Amino acid sequence
>lcl|BSEQ0022105|Penicillin-binding protein 1b MQNQLNELKRKMLEFFQQKQKNKKSARPGKKGSSTKKSKTLDKSAIFPAILLSIKALFNL LFVLGFLGGMLGAGIALGYGVALFDKVRVPQTEELVNQVKDISSISEITYSDGTVIASIE SDLLRTSISSEQISENLKKAIIATEDEHFKEHKGVVPKAVIRATLGKFVGLGSSSGGSTL TQQLIKQQVVGDAPTLARKAAEIVDALALERAMNKDEILTTYLNVAPFGRNNKGQNIAGA RQAAEGIFGVDASQLTVPQAAFLAGLPQSPITYSPYENTGELKSDEDLEIGLRRAKAVLY SMYRTGALSKDEYSQYKDYDLKQDFLPSGTVTGISRDYLYFTTLAEAQERMYDYLAQRDN VSAKELKNEATQKFYRDLAAKEIENGGYKITTTIDQKIHSAMQSAVADYGYLLDDGTGRV EVGNVLMDNQTGAILGFVGGRNYQENQNNHAFDTKRSPASTTKPLLAYGIAIDQGLMGSE TILSNYPTNFANGNPIMYANSKGTGMMTLGEALNYSWNIPAYWTYRMLRENGVDVKGYME KMGYEIPEYGIESLPMGGGIEVTVAQHTNGYQTLANNGVYHQKHVISKIEAADGRVVYEY QDKPVQVYSKATATIMQGLLREVLSSRVTTTFKSNLTSLNPTLANADWIGKTGTTNQDEN MWLMLSTPRLTLGGWIGHDDNHSLSRRAGYSNNSNYMAHLVNAIQQASPSIWGNERFALD PSVVKSEVLKSTGQKPGKVSVEGKEVEVTGSTVTSYWANKSGAPATSYRFAIGGSDADYQ NAWSSIVGSLPTPSSSSSSSSSSSDSSNSSTTRPSSSRARR
- Number of residues
- 821
- Molecular Weight
- 89479.92
- Theoretical pI
- 8.82
- GO Classification
- Functionspenicillin binding / peptidoglycan glycosyltransferase activity / transferase activity, transferring acyl groupsComponentsintegral component of membrane
- General Function
- Transferase activity, transferring acyl groups
- Specific Function
- Not Available
- Pfam Domain Function
- Transmembrane Regions
- 60-84
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0022106|Penicillin-binding protein 1b (pbp1b) ATGCAAAATCAATTAAATGAATTAAAACGAAAAATGCTGGAATTTTTCCAGCAAAAACAA AAAAATAAAAAATCAGCTAGACCTGGCAAGAAAGGTTCAAGTACCAAAAAATCTAAAACC TTAGATAAGTCAGCCATTTTCCCAGCTATTTTACTGAGTATAAAAGCCTTATTTAACTTA CTCTTTGTACTCGGTTTTCTAGGAGGAATGTTGGGAGCTGGGATTGCTTTGGGGTACGGA GTGGCCTTATTTGACAAGGTTCGGGTGCCTCAGACAGAAGAATTGGTGAATCAGGTCAAG GACATCTCTTCTATTTCAGAGATTACCTATTCGGACGGGACGGTGATTGCTTCCATAGAG AGTGATTTGTTGCGCACTTCTATCTCATCTGAGCAAATTTCGGAAAATCTGAAGAAGGCT ATCATTGCGACAGAAGATGAACACTTTAAAGAACATAAGGGTGTAGTACCCAAGGCGGTG ATTCGTGCGACCTTGGGGAAATTTGTAGGTTTGGGTTCCTCTAGTGGGGGTTCAACCTTG ACCCAGCAACTAATTAAACAGCAGGTGGTTGGGGATGCGCCGACCTTGGCTCGTAAGGCG GCAGAGATTGTGGATGCTCTTGCCTTGGAACGCGCCATGAATAAAGATGAGATTTTAACG ACCTATCTCAATGTGGCTCCCTTTGGCCGAAATAATAAGGGACAGAATATTGCAGGGGCT CGGCAAGCAGCTGAGGGAATTTTCGGTGTAGATGCCAGTCAGTTGACTGTTCCTCAAGCA GCATTTTTAGCAGGACTTCCACAGAGTCCCATTACTTACTCTCCTTATGAAAATACTGGG GAGTTGAAGAGTGATGAAGACCTAGAAATTGGCTTAAGACGGGCTAAGGCAGTTCTTTAC AGTATGTATCGTACAGGTGCATTAAGCAAAGACGAGTATTCTCAGTACAAGGATTATGAC CTTAAACAGGACTTTTTACCATCGGGCACGGTTACAGGAATTTCACGAGACTATTTATAC TTTACAACTTTGGCAGAAGCTCAAGAACGTATGTATGACTATCTAGCTCAGAGAGACAAT GTCTCCGCTAAGGAGTTGAAAAATGAGGCAACTCAGAAGTTTTATCGAGATTTGGCAGCC AAGGAAATTGAAAATGGTGGTTATAAGATTACTACTACCATAGATCAGAAAATTCATTCT GCCATGCAAAGTGCGGTTGCTGATTATGGCTATCTTTTAGACGATGGAACAGGTCGTGTA GAAGTAGGGAATGTCTTGATGGACAACCAAACAGGTGCTATTCTAGGCTTTGTAGGTGGT CGTAATTATCAAGAAAATCAAAATAATCATGCCTTTGATACCAAACGTTCGCCAGCTTCT ACTACCAAGCCCTTGCTGGCCTACGGTATTGCTATTGACCAGGGCTTGATGGGAAGTGAA ACGATTCTATCTAACTATCCAACAAACTTTGCTAATGGCAATCCGATTATGTATGCTAAT AGCAAGGGAACAGGAATGATGACCTTGGGAGAAGCTCTGAACTACTCATGGAATATCCCT GCTTACTGGACCTATCGTATGCTCCGTGAAAATGGTGTTGATGTCAAGGGTTATATGGAA AAGATGGGTTACGAGATTCCTGAGTACGGTATTGAGAGCTTGCCAATGGGTGGTGGTATT GAAGTCACAGTTGCCCAGCATACCAATGGCTATCAGACCTTAGCTAATAATGGAGTTTAT CATCAGAAGCATGTGATTTCAAAGATTGAAGCAGCAGATGGTAGAGTGGTGTATGAGTAT CAGGATAAACCGGTTCAAGTCTATTCAAAAGCTACTGCGACGATTATGCAGGGATTGCTA CGAGAAGTTCTATCCTCTCGTGTGACAACAACCTTCAAGTCTAACCTGACTTCTTTAAAT CCTACTCTGGCTAATGCAGATTGGATTGGGAAGACTGGTACAACCAACCAAGACGAAAAT ATGTGGCTCATGCTTTCGACACCTAGATTAACCCTAGGTGGCTGGATTGGGCATGATGAT AATCATTCATTGTCACGTAGAGCAGGTTATTCTAATAACTCTAATTACATGGCTCATCTG GTAAATGCGATTCAGCAAGCTTCCCCAAGCATTTGGGGGAACGAGCGCTTTGCTTTAGAT CCTAGTGTAGTGAAATCGGAAGTCTTGAAATCAACAGGTCAAAAACCAGGGAAGGTTTCT GTTGAAGGAAAAGAGGTAGAGGTCACAGGTTCGACTGTTACCAGCTATTGGGCTAATAAG TCAGGAGCGCCAGCGACAAGTTATCGCTTTGCTATTGGCGGAAGTGATGCGGATTATCAG AATGCTTGGTCTAGTATTGTGGGGAGTCTACCAACTCCATCCAGCTCCAGCAGTTCAAGT AGTAGTTCTAGCGATAGCAGTAACTCAAGTACTACACGACCTTCTTCTTCAAGGGCGAGA CGATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q7CRA4 UniProtKB Entry Name Q7CRA4_STRR6 GenBank Protein ID 15457529 GenBank Gene ID AE007317 - General References
- Hoskins J, Alborn WE Jr, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR Jr, Skatrud PL, Glass JI: Genome of the bacterium Streptococcus pneumoniae strain R6. J Bacteriol. 2001 Oct;183(19):5709-17. [Article]
- Macheboeuf P, Di Guilmi AM, Job V, Vernet T, Dideberg O, Dessen A: Active site restructuring regulates ligand recognition in class A penicillin-binding proteins. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):577-82. Epub 2005 Jan 6. [Article]
- Contreras-Martel C, Amoroso A, Woon EC, Zervosen A, Inglis S, Martins A, Verlaine O, Rydzik AM, Job V, Luxen A, Joris B, Schofield CJ, Dessen A: Structure-guided design of cell wall biosynthesis inhibitors that overcome beta-lactam resistance in Staphylococcus aureus (MRSA). ACS Chem Biol. 2011 Sep 16;6(9):943-51. doi: 10.1021/cb2001846. Epub 2011 Aug 3. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB08508 N-BENZOYL-D-ALANINE experimental unknown Details DB01140 Cefadroxil approved, vet_approved, withdrawn yes inhibitor Details DB00493 Cefotaxime approved yes inhibitor Details DB00319 Piperacillin approved yes inhibitor Details DB00607 Nafcillin approved, investigational yes inhibitor Details DB00415 Ampicillin approved, vet_approved yes inhibitor Details DB00485 Dicloxacillin approved, investigational, vet_approved yes inhibitor Details DB01163 Amdinocillin investigational, withdrawn yes inhibitor Details DB01603 Meticillin approved, investigational yes inhibitor Details DB00456 Cefalotin approved, investigational, vet_approved yes inhibitor Details DB00713 Oxacillin approved, investigational yes inhibitor Details DB01331 Cefoxitin approved yes inhibitor Details DB00567 Cephalexin approved, investigational, vet_approved yes inhibitor Details DB03313 Cephalosporin C experimental yes inhibitor Details DB08795 Azidocillin experimental yes inhibitor Details DB00739 Hetacillin approved, vet_approved, withdrawn yes inhibitor Details