Plasmepsin-1

Details

Name
Plasmepsin-1
Synonyms
  • 3.4.23.38
  • Aspartic hemoglobinase I
  • PfAPG
Gene Name
Not Available
Organism
Plasmodium falciparum (isolate 3D7)
Amino acid sequence
>lcl|BSEQ0051421|Plasmepsin-1
MALSIKEDFSSAFAKNESAVNSSTFNNNMKTWKIQKRFQILYVFFFLLITGALFYYLIDN
VLFPKNKKINEIMNTSKHVIIGFSIENSHDRIMKTVKQHRLKNYIKESLKFFKTGLTQKP
HLGNAGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNL
YDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTL
GQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRF
YEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVV
KIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKN
TFILGDPFMRKYFTVFDYDNHTVGFALAKKKL
Number of residues
452
Molecular Weight
51460.555
Theoretical pI
Not Available
GO Classification
Functions
aspartic-type endopeptidase activity
Processes
hemoglobin catabolic process
Components
food vacuole
General Function
Participates in the digestion of the host hemoglobin. Initial cleavage at the hinge region of hemoglobin, than cleaves at other sites, leading to denaturation of the molecule and to further degradation (By similarity).
Specific Function
Aspartic-type endopeptidase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Vacuole
Gene sequence
>lcl|BSEQ0051422|Plasmepsin-1
ATGGCTTTATCAATTAAAGAAGATTTTTCAAGCGCTTTTGCGAAAAATGAATCAGCTGTG
AATAGCTCTACATTTAATAATAATATGAAAACATGGAAGATTCAGAAACGATTTCAAATA
TTATACGTGTTTTTTTTCTTATTGATTACCGGAGCATTATTTTATTATCTTATAGATAAT
GTATTATTCCCAAAAAATAAAAAGATAAATGAAATTATGAATACCTCAAAACATGTAATA
ATTGGATTTAGTATTGAAAATTCTCATGACAGAATTATGAAAACAGTAAAACAACACAGA
TTAAAAAATTATATTAAAGAATCCTTGAAATTTTTCAAAACAGGACTTACACAAAAACCA
CATTTAGGTAATGCTGGTGATAGTGTAACATTAAATGATGTAGCTAATGTAATGTATTAT
GGAGAAGCTCAAATTGGAGATAATAAACAAAAGTTTGCTTTTATTTTTGATACAGGATCA
GCAAATTTATGGGTTCCAAGTGCTCAATGTAATACTATTGGCTGTAAAACAAAAAATCTT
TATGATTCTAATAAATCCAAAACATATGAAAAAGATGGTACTAAAGTAGAAATGAATTAT
GTATCTGGAACAGTAAGCGGATTTTTTAGTAAAGATATAGTTACTATAGCAAATTTATCA
TTTCCATATAAATTTATTGAAGTTACAGATACCAATGGTTTCGAACCAGCTTATACCTTA
GGACAATTTGATGGTATAGTAGGTTTAGGATGGAAAGATTTGTCTATAGGTTCAGTAGAT
CCTGTTGTTGTCGAATTAAAAAATCAAAATAAAATCGAACAAGCCGTTTTTACCTTTTAT
TTACCATTTGATGATAAACACAAAGGTTATTTAACCATAGGAGGTATTGAAGATAGATTT
TATGAAGGTCAATTAACTTATGAAAAATTAAACCACGATTTATATTGGCAAGTTGATTTA
GATCTACATTTTGGTAATTTAACTGTAGAAAAAGCTACTGCAATTGTTGACAGTGGTACT
AGTTCTATAACGGCACCAACTGAATTCCTTAACAAATTCTTTGAAGGTTTAGATGTTGTT
AAAATACCTTTCTTACCATTATATATAACTACATGTAATAACCCTAAATTACCAACTCTA
GAATTCAGATCAGCAACAAATGTTTATACCTTAGAACCAGAATACTACTTACAACAAATA
TTCGATTTTGGTATATCATTATGTATGGTATCTATAATACCTGTTGATTTGAACAAAAAT
ACCTTCATATTAGGTGACCCATTCATGAGAAAATATTTCACCGTCTTTGATTATGATAAT
CACACTGTTGGTTTCGCCCTTGCCAAAAAAAAATTGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ7KQM4
UniProtKB Entry NamePLM1_PLAF7
General References
  1. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails