Macrophage erythroblast attacher
Details
- Name
- Macrophage erythroblast attacher
- Synonyms
- Cell proliferation-inducing gene 5 protein
- EMP
- Erythroblast macrophage protein
- HLC-10
- Human lung cancer oncogene 10 protein
- Gene Name
- MAEA
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006583|Macrophage erythroblast attacher MAVQESAAQLSMTLKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSG CPAVDSVVSLLDGVVEKLSVLKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASVW KRKRMDRMMVEHLLRCGYYNTAVKLARQSGIEDLVNIEMFLTAKEVEESLERRETATCLA WCHDNKSRLRKMKSCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAEGSQLDEVRQAM GMLAFPPDTHISPYKDLLDPARWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTP QCYKEDGSSKSPDCPVCSRSLNKLAQPLPMAHCANSRLVCKISGDVMNENNPPMMLPNGY VYGYNSLLSIRQDDKVVCPRTKEVFHFSQAEKVYIM
- Number of residues
- 396
- Molecular Weight
- 45286.895
- Theoretical pI
- 8.87
- GO Classification
- Functionsactin bindingProcessescell adhesion / cell cycle / cell division / cytoskeleton organization / enucleate erythrocyte development / erythrocyte maturation / negative regulation of myeloid cell apoptotic process / regulation of mitotic cell cycleComponentsactomyosin contractile ring / cytoplasm / cytoskeleton / integral component of plasma membrane / nuclear matrix / nucleus / spindle
- General Function
- Actin binding
- Specific Function
- Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.
- Pfam Domain Function
- CLTH (PF10607)
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus matrix
- Gene sequence
>lcl|BSEQ0012359|Macrophage erythroblast attacher (MAEA) ATGGCGGTGCAGGAGTCGGCGGCTCAGTTGTCCATGACCCTGAAGGTCCAGGAGTACCCG ACCCTCAAGGTGCCCTACGAGACGCTGAACAAACGCTTTCGCGCCGCTCAGAAGAACATT GACCGGGAGACCAGCCACGTCACCATGGTGGTGGCCGAGCTGGAGAAGACGTTGAGCGGC TGCCCCGCCGTGGACTCCGTGGTCAGCCTGCTGGACGGCGTGGTGGAGAAGCTCAGCGTC CTCAAGAGGAAGGCGGTGGAATCCATCCAGGCCGAGGACGAGAGCGCCAAGCTGTGCAAG CGCCGGATCGAGCACCTCAAAGAGCATAGCAGCGACCAGCCCGCGGCGGCCAGCGTGTGG AAGAGGAAGCGCATGGATCGCATGATGGTGGAGCACCTGCTGCGTTGCGGCTACTACAAC ACGGCTGTCAAGCTGGCGCGCCAGAGCGGCATCGAGGACCTAGTGAATATTGAGATGTTC CTGACGGCCAAAGAGGTGGAGGAGTCCCTGGAGAGGCGTGAGACGGCCACCTGCCTGGCC TGGTGCCATGACAACAAGTCCCGGCTCCGGAAGATGAAGAGCTGCCTGGAGTTCAGCCTC AGAATCCAGGAGTTCATTGAACTCATCCGGCAGAATAAGAGACTGGACGCTGTGAGACAT GCAAGAAAGCACTTCAGCCAAGCAGAAGGGAGCCAGCTGGACGAGGTGCGCCAGGCCATG GGCATGCTGGCCTTCCCGCCCGACACGCACATCTCCCCGTACAAGGACCTTCTGGACCCT GCACGGTGGCGGATGCTGATCCAGCAGTTCCGGTACGACAACTACCGACTACACCAGCTG GGAAACAATTCTGTGTTCACCCTCACCCTGCAGGCTGGCCTCTCAGCCATCAAGACACCA CAGTGCTACAAGGAGGACGGCAGCTCCAAGAGCCCTGACTGCCCTGTGTGCAGCCGCTCC CTGAACAAGCTGGCGCAGCCCCTGCCCATGGCCCACTGTGCCAACTCCCGCCTGGTCTGC AAGATTTCTGGCGACGTGATGAACGAGAACAATCCGCCCATGATGCTGCCCAACGGCTAC GTCTACGGCTACAATTCTCTGCTTTCTATCCGTCAAGATGATAAAGTCGTGTGCCCGAGA ACCAAAGAAGTCTTCCACTTCTCACAAGCCGAGAAGGTGTACATCATGTAG
- Chromosome Location
- 4
- Locus
- 4p16.3
- External Identifiers
Resource Link UniProtKB ID Q7L5Y9 UniProtKB Entry Name MAEA_HUMAN GenBank Gene ID AK001088 GenAtlas ID MAEA HGNC ID HGNC:13731 - General References
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