Macrophage erythroblast attacher

Details

Name
Macrophage erythroblast attacher
Synonyms
  • Cell proliferation-inducing gene 5 protein
  • EMP
  • Erythroblast macrophage protein
  • HLC-10
  • Human lung cancer oncogene 10 protein
Gene Name
MAEA
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006583|Macrophage erythroblast attacher
MAVQESAAQLSMTLKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSG
CPAVDSVVSLLDGVVEKLSVLKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASVW
KRKRMDRMMVEHLLRCGYYNTAVKLARQSGIEDLVNIEMFLTAKEVEESLERRETATCLA
WCHDNKSRLRKMKSCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAEGSQLDEVRQAM
GMLAFPPDTHISPYKDLLDPARWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTP
QCYKEDGSSKSPDCPVCSRSLNKLAQPLPMAHCANSRLVCKISGDVMNENNPPMMLPNGY
VYGYNSLLSIRQDDKVVCPRTKEVFHFSQAEKVYIM
Number of residues
396
Molecular Weight
45286.895
Theoretical pI
8.87
GO Classification
Functions
actin binding
Processes
cell adhesion / cell cycle / cell division / cytoskeleton organization / enucleate erythrocyte development / erythrocyte maturation / negative regulation of myeloid cell apoptotic process / regulation of mitotic cell cycle
Components
actomyosin contractile ring / cytoplasm / cytoskeleton / integral component of plasma membrane / nuclear matrix / nucleus / spindle
General Function
Actin binding
Specific Function
Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus matrix
Gene sequence
>lcl|BSEQ0012359|Macrophage erythroblast attacher (MAEA)
ATGGCGGTGCAGGAGTCGGCGGCTCAGTTGTCCATGACCCTGAAGGTCCAGGAGTACCCG
ACCCTCAAGGTGCCCTACGAGACGCTGAACAAACGCTTTCGCGCCGCTCAGAAGAACATT
GACCGGGAGACCAGCCACGTCACCATGGTGGTGGCCGAGCTGGAGAAGACGTTGAGCGGC
TGCCCCGCCGTGGACTCCGTGGTCAGCCTGCTGGACGGCGTGGTGGAGAAGCTCAGCGTC
CTCAAGAGGAAGGCGGTGGAATCCATCCAGGCCGAGGACGAGAGCGCCAAGCTGTGCAAG
CGCCGGATCGAGCACCTCAAAGAGCATAGCAGCGACCAGCCCGCGGCGGCCAGCGTGTGG
AAGAGGAAGCGCATGGATCGCATGATGGTGGAGCACCTGCTGCGTTGCGGCTACTACAAC
ACGGCTGTCAAGCTGGCGCGCCAGAGCGGCATCGAGGACCTAGTGAATATTGAGATGTTC
CTGACGGCCAAAGAGGTGGAGGAGTCCCTGGAGAGGCGTGAGACGGCCACCTGCCTGGCC
TGGTGCCATGACAACAAGTCCCGGCTCCGGAAGATGAAGAGCTGCCTGGAGTTCAGCCTC
AGAATCCAGGAGTTCATTGAACTCATCCGGCAGAATAAGAGACTGGACGCTGTGAGACAT
GCAAGAAAGCACTTCAGCCAAGCAGAAGGGAGCCAGCTGGACGAGGTGCGCCAGGCCATG
GGCATGCTGGCCTTCCCGCCCGACACGCACATCTCCCCGTACAAGGACCTTCTGGACCCT
GCACGGTGGCGGATGCTGATCCAGCAGTTCCGGTACGACAACTACCGACTACACCAGCTG
GGAAACAATTCTGTGTTCACCCTCACCCTGCAGGCTGGCCTCTCAGCCATCAAGACACCA
CAGTGCTACAAGGAGGACGGCAGCTCCAAGAGCCCTGACTGCCCTGTGTGCAGCCGCTCC
CTGAACAAGCTGGCGCAGCCCCTGCCCATGGCCCACTGTGCCAACTCCCGCCTGGTCTGC
AAGATTTCTGGCGACGTGATGAACGAGAACAATCCGCCCATGATGCTGCCCAACGGCTAC
GTCTACGGCTACAATTCTCTGCTTTCTATCCGTCAAGATGATAAAGTCGTGTGCCCGAGA
ACCAAAGAAGTCTTCCACTTCTCACAAGCCGAGAAGGTGTACATCATGTAG
Chromosome Location
4
Locus
4p16.3
External Identifiers
ResourceLink
UniProtKB IDQ7L5Y9
UniProtKB Entry NameMAEA_HUMAN
GenBank Gene IDAK001088
GenAtlas IDMAEA
HGNC IDHGNC:13731
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  3. Hanspal M, Smockova Y, Uong Q: Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages. Blood. 1998 Oct 15;92(8):2940-50. [Article]
  4. Bala S, Kumar A, Soni S, Sinha S, Hanspal M: Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division. Biochem Biophys Res Commun. 2006 Apr 21;342(4):1040-8. Epub 2006 Feb 21. [Article]
  5. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05389Tetrachlorodecaoxideapproved, investigationalunknownDetails