CLIP-associating protein 1

Details

Name

CLIP-associating protein 1

Synonyms

• Cytoplasmic linker-associated protein 1
• hOrbit1
• KIAA0622
• MAST1
• Multiple asters homolog 1
• Protein Orbit homolog 1

Gene Name

CLASP1

Organism

Humans

Amino acid sequence

>lcl|BSEQ0051844|CLIP-associating protein 1
MEPRMESCLAQVLQKDVGKRLQVGQELIDYFSDKQKSADLEHDQTMLDKLVDGLATSWVN
SSNYKVVLLGMDILSALVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMD
QAANPQYVWDRMLGGFKHKNFRTREGICLCLIATLNASGAQTLTLSKIVPHICNLLGDPN
SQVRDAAINSLVEIYRHVGERVRADLSKKGLPQSRLNVIFTKFDEVQKSGNMIQSANDKN
FDDEDSVDGNRPSSASSTSSKAPPSSRRNVGMGTTRRLGSSTLGSKSSAAKEGAGAVDEE
DFIKAFDDVPVVQIYSSRDLEESINKIREILSDDKHDWEQRVNALKKIRSLLLAGAAEYD
NFFQHLRLLDGAFKLSAKDLRSQVVREACITLGHLSSVLGNKFDHGAEAIMPTIFNLIPN
SAKIMATSGVVAVRLIIRHTHIPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQEWQTHSL
ERHISVLAETIKKGIHDADSEARIEARKCYWGFHSHFSREAEHLYHTLESSYQKALQSHL
KNSDSIVSLPQSDRSSSSSQESLNRPLSAKRSPTGSTTSRASTVSTKSVSTTGSLQRSRS
DIDVNAAASAKSKVSSSSGTTPFSSAAALPPGSYASLGRIRTRRQSSGSATNVASTPDNR
GRSRAKVVSQSQRSRSANPAGAGSRSSSPGKLLGSGYGGLTGGSSRGPPVTPSSEKRSKI
PRSQGCSRETSPNRIGLARSSRIPRPSMSQGCSRDTSRESSRDTSPARGFPPLDRFGLGQ
PGRIPGSVNAMRVLSTSTDLEAAVADALKKPVRRRYEPYGMYSDDDANSDASSVCSERSY
GSRNGGIPHYLRQTEDVAEVLNHCASSNWSERKEGLLGLQNLLKSQRTLSRVELKRLCEI
FTRMFADPHSKRVFSMFLETLVDFIIIHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQ
KALDVTRDSFPFDQQFNILMRFIVDQTQTPNLKVKVAILKYIESLARQMDPTDFVNSSET
RLAVSRIITWTTEPKSSDVRKAAQIVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNH
LKNSSNTSVGSPSNTIGRTPSRHTSSRTSPLTSPTNCSHGGLSPSRLWGWSADGLAKHPP
PFSQPNSIPTAPSHKALRRSYSPSMLDYDTENLNSEEIYSSLRGVTEAIEKFSFRSQEDL
NEPIKRDGKKECDIVSRDGGAASPATEGRGGSEVEGGRTALDNKTSLLNTQPPRAFPGPR
ARDYNPYPYSDAINTYDKTALKEAVFDDDMEQLRDVPIDHSDLVADLLKELSNHNERVEE
RKGALLELLKITREDSLGVWEEHFKTILLLLLETLGDKDHSIRALALRVLREILRNQPAR
FKNYAELTIMKTLEAHKDSHKEVVRAAEEAASTLASSIHPEQCIKVLCPIIQTADYPINL
AAIKMQTKVVERIAKESLLQLLVDIIPGLLQGYDNTESSVRKASVFCLVAIYSVIGEDLK
PHLAQLTGSKMKLLNLYIKRAQTTNSNSSSSSDVSTHS

Number of residues

1538

Molecular Weight

169448.635

Theoretical pI

Not Available

GO Classification

Functions

dystroglycan binding / kinetochore binding / microtubule binding / microtubule plus-end binding

Processes

astral microtubule organization / cell division / ciliary basal body-plasma membrane docking / establishment of epithelial cell polarity / establishment of mitotic spindle localization / establishment of spindle orientation / establishment or maintenance of cell polarity / exit from mitosis / G2/M transition of mitotic cell cycle / Golgi organization / microtubule anchoring / microtubule bundle formation / microtubule cytoskeleton organization / microtubule nucleation / microtubule organizing center organization / mitotic spindle assembly / mitotic spindle organization / negative regulation of microtubule depolymerization / negative regulation of microtubule polymerization or depolymerization / negative regulation of stress fiber assembly / negative regulation of wound healing, spreading of epidermal cells / positive regulation of basement membrane assembly involved in embryonic body morphogenesis / positive regulation of epithelial cell migration / positive regulation of exocytosis / positive regulation of extracellular matrix disassembly / positive regulation of microtubule polymerization / regulation of epithelial to mesenchymal transition / regulation of focal adhesion assembly / regulation of G2/M transition of mitotic cell cycle / regulation of gastrulation / regulation of microtubule cytoskeleton organization / sister chromatid cohesion / vesicle targeting

Components

basal cortex / cell cortex / centrosomal corona / centrosome / condensed chromosome kinetochore / cortical microtubule cytoskeleton / cytoplasmic microtubule / cytosol / extracellular exosome / Golgi apparatus / kinetochore / kinetochore microtubule / membrane / microtubule plus-end / spindle microtubule

General Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.

Specific Function

Dystroglycan binding

Pfam Domain Function

• CLASP_N (PF12348)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0051845|CLIP-associating protein 1 (CLASP1)
ATGGAGCCTCGCATGGAGTCCTGCCTGGCGCAGGTGTTGCAGAAGGATGTGGGGAAACGA
TTGCAGGTTGGCCAAGAACTGATAGACTATTTCTCAGACAAACAGAAGTCTGCTGACCTT
GAGCATGACCAGACCATGTTAGATAAACTTGTGGATGGACTTGCTACCTCTTGGGTGAAC
TCTAGCAATTACAAGGTGGTTCTGCTGGGCATGGACATCCTGTCCGCCCTGGTGACCCGG
CTGCAGGATCGGTTCAAGGCGCAGATCGGCACAGTGCTGCCAAGTCTAATAGACAGACTA
GGAGATGCTAAAGACTCTGTGAGGGAGCAGGACCAAACTCTGCTGCTAAAGATCATGGAT
CAAGCTGCTAATCCCCAGTACGTATGGGACAGAATGCTTGGAGGCTTCAAACACAAGAAT
TTCCGTACTCGAGAAGGCATCTGTCTCTGCCTTATAGCAACACTCAATGCCTCTGGAGCA
CAGACTTTAACACTAAGCAAGATTGTGCCACATATATGCAACTTACTTGGAGATCCAAAC
AGCCAGGTTCGAGATGCAGCAATAAACAGCTTAGTGGAAATTTACAGACATGTAGGAGAA
CGTGTGAGGGCAGATCTCAGTAAAAAAGGATTGCCACAGTCCCGGTTGAATGTAATTTTT
ACAAAATTTGATGAAGTCCAGAAATCTGGAAACATGATACAATCTGCAAATGATAAAAAT
TTCGACGATGAAGATTCTGTGGATGGTAACAGACCTTCCTCTGCTAGTTCTACATCATCC
AAGGCTCCACCAAGTTCTCGGAGAAACGTTGGAATGGGAACCACCCGCCGGCTTGGTTCA
TCCACCCTTGGATCCAAGTCTTCAGCTGCAAAAGAAGGAGCTGGTGCTGTTGATGAAGAG
GATTTTATTAAAGCATTTGATGATGTACCTGTAGTACAGATTTATTCCAGCCGAGACCTT
GAGGAATCCATAAACAAAATTAGGGAAATATTATCTGATGACAAGCATGATTGGGAGCAG
AGAGTAAATGCTCTAAAAAAGATTAGATCTTTACTTTTGGCTGGTGCTGCTGAGTATGAT
AACTTCTTTCAACATTTGCGTCTTTTGGATGGAGCCTTTAAACTCTCTGCTAAGGACCTG
CGGTCTCAGGTAGTGCGGGAGGCTTGTATCACGTTGGGGCATCTGTCATCAGTTCTGGGG
AATAAGTTTGACCATGGAGCTGAAGCCATTATGCCAACTATCTTTAATTTAATTCCAAAC
AGTGCCAAAATTATGGCCACATCTGGTGTTGTAGCTGTTAGGTTAATTATTCGGCACACA
CACATCCCTAGGTTAATACCTGTCATAACAAGCAACTGTACCTCTAAGTCTGTCGCAGTT
AGAAGGCGCTGTTTTGAATTTTTAGATTTGCTTTTACAAGAATGGCAGACACATTCACTA
GAACGACACATATCAGTATTAGCTGAAACAATAAAGAAGGGAATACATGATGCTGATTCC
GAAGCAAGAATAGAAGCCAGAAAATGTTACTGGGGTTTCCACAGTCACTTCAGCAGAGAA
GCAGAGCACTTGTACCACACCTTGGAGTCCTCCTACCAGAAAGCCCTGCAGTCCCACCTG
AAGAACTCAGACAGCATAGTGTCTCTGCCTCAGTCAGACCGCTCATCTTCCAGCTCTCAA
GAGAGTCTAAATCGTCCGCTGTCTGCCAAAAGAAGTCCTACTGGAAGTACCACATCTAGA
GCTTCTACAGTTAGTACCAAATCTGTGTCAACGACTGGGTCCCTCCAGCGATCTCGAAGT
GATATTGATGTGAACGCAGCAGCCAGTGCCAAATCCAAAGTCTCCTCATCTTCGGGCACG
ACGCCTTTCAGCTCTGCAGCAGCTTTGCCTCCAGGGTCATACGCATCCTTAGGTCGGATC
CGCACAAGACGGCAAAGCTCTGGGAGTGCCACCAACGTCGCCTCTACACCTGATAACCGG
GGCCGCAGTCGCGCTAAAGTGGTTTCACAGTCCCAGCGATCCAGATCTGCTAATCCTGCT
GGTGCTGGCAGCCGGTCAAGTTCCCCAGGAAAATTGTTGGGAAGTGGTTATGGTGGACTT
ACTGGGGGCTCCTCACGAGGCCCACCTGTGACACCGTCTTCAGAAAAGCGAAGCAAGATT
CCCAGGAGCCAGGGATGTAGCCGGGAAACAAGTCCAAACCGAATAGGATTAGCACGGAGC
AGCCGTATCCCTCGACCCAGCATGAGTCAGGGGTGCAGCCGCGATACCAGCCGTGAGAGC
AGCCGAGATACAAGCCCTGCTCGGGGCTTTCCTCCACTTGATCGGTTTGGGCTTGGCCAG
CCAGGAAGAATACCTGGTTCTGTGAATGCCATGAGAGTTCTGAGCACAAGTACAGATCTT
GAAGCTGCTGTTGCTGATGCTTTGAAGAAGCCTGTGAGGAGGAGATATGAGCCGTATGGG
ATGTATTCTGACGATGATGCCAACAGTGATGCCTCAAGTGTTTGCTCTGAGCGCTCATAT
GGCTCCAGGAATGGTGGCATTCCCCATTATCTGCGGCAGACTGAGGATGTAGCAGAAGTT
CTCAACCACTGTGCTAGTTCAAACTGGTCAGAAAGGAAAGAAGGGCTTCTGGGCCTGCAG
AACTTACTGAAGAGCCAAAGAACACTGAGTCGAGTTGAACTGAAAAGGTTGTGTGAGATC
TTCACTCGGATGTTTGCTGACCCTCATAGCAAGAGAGTTTTCAGTATGTTTTTGGAGACT
CTTGTGGATTTTATAATAATTCATAAGGATGATTTACAAGACTGGCTTTTTGTTCTTCTC
ACACAATTACTTAAGAAAATGGGAGCAGATTTACTTGGATCTGTGCAAGCAAAAGTTCAA
AAGGCTCTAGATGTCACAAGGGACTCCTTTCCATTTGATCAACAATTTAACATTTTGATG
AGATTTATTGTGGATCAAACTCAAACTCCAAACCTCAAGGTCAAAGTTGCAATCCTGAAA
TACATTGAGTCTCTGGCCAGACAGATGGATCCAACAGATTTTGTAAACTCTAGTGAGACA
AGGCTTGCTGTTTCTAGAATCATAACCTGGACAACAGAACCAAAGAGTTCAGACGTGAGA
AAGGCAGCACAGATTGTGCTAATCTCTCTGTTTGAATTGAATACTCCTGAATTTACCATG
TTACTTGGTGCCTTGCCAAAAACATTCCAGGATGGTGCCACCAAACTCCTGCACAACCAC
CTCAAGAATTCCAGTAACACCAGTGTGGGCTCTCCAAGCAATACGATTGGCCGGACGCCC
TCCCGACACACCAGCAGCAGGACCAGCCCCCTGACCTCACCCACCAACTGTTCCCATGGG
GGTCTGTCTCCAAGTCGGTTATGGGGTTGGAGTGCCGACGGGTTAGCGAAGCACCCACCT
CCCTTTTCTCAGCCTAACTCCATCCCCACCGCTCCCTCCCACAAGGCTCTCAGGCGCTCT
TACTCTCCCAGCATGCTGGACTATGATACAGAGAACCTGAACTCTGAAGAAATCTATAGT
TCTCTACGTGGAGTTACAGAAGCCATTGAAAAGTTTAGTTTTCGAAGCCAAGAAGATCTG
AATGAGCCAATTAAACGAGATGGCAAAAAGGAGTGTGATATTGTGTCCCGCGATGGGGGC
GCTGCCTCCCCTGCCACTGAGGGCCGGGGGGGTAGTGAAGTAGAAGGAGGCCGGACAGCT
CTGGATAACAAGACCTCACTACTCAACACCCAGCCTCCGCGCGCCTTCCCGGGGCCGCGG
GCGCGAGACTACAACCCGTACCCCTACTCAGATGCCATCAACACCTACGACAAGACCGCC
CTGAAAGAGGCTGTGTTCGATGACGACATGGAGCAGCTTCGAGACGTGCCCATCGACCAT
TCTGACCTGGTGGCTGACCTTCTGAAAGAGCTGTCCAACCACAATGAGCGAGTGGAGGAA
CGGAAGGGAGCCCTGCTGGAGCTGCTCAAGATCACGCGGGAAGACAGCCTTGGTGTCTGG
GAGGAGCACTTCAAGACCATTCTGCTCCTGCTGCTGGAGACCCTTGGAGACAAAGACCAT
TCAATTCGAGCACTGGCGTTAAGAGTTTTGAGGGAAATTCTGAGAAATCAACCAGCAAGA
TTTAAAAACTACGCCGAGCTGACGATTATGAAGACTCTGGAAGCCCACAAAGACTCCCAT
AAGGAGGTGGTGAGAGCGGCTGAGGAGGCTGCGTCCACACTGGCCAGTTCCATCCACCCG
GAGCAGTGCATCAAGGTGCTCTGCCCCATCATCCAGACGGCCGACTACCCCATCAACCTT
GCTGCCATCAAGATGCAGACCAAAGTCGTCGAGAGGATCGCAAAGGAGTCATTGCTGCAG
CTCCTTGTCGACATCATCCCAGGCTTGCTGCAGGGTTATGACAACACCGAAAGTAGTGTG
CGTAAGGCCAGCGTGTTTTGCTTAGTGGCAATTTATTCCGTAATCGGAGAAGACCTGAAA
CCTCACCTTGCACAGCTCACAGGGAGCAAGATGAAGCTACTAAACTTATACATAAAGAGG
GCCCAGACCACCAACAGCAACAGCAGCTCCTCCTCCGATGTCTCCACGCACAGCTAA

Chromosome Location

2

Locus

2q14.2-q14.3

External Identifiers

Resource	Link
UniProtKB ID	Q7Z460
UniProtKB Entry Name	CLAP1_HUMAN
HGNC ID	HGNC:17088

General References

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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB12010	Fostamatinib	approved, investigational	unknown	inhibitor	Details