Glycosyltransferase 6 domain-containing protein 1

Details

Name

Glycosyltransferase 6 domain-containing protein 1

Synonyms

• 2.4.1.-
• Galactosyltransferase family 6 domain-containing 1
• GLTDC1
• GT6M7

Gene Name

GLT6D1

Organism

Humans

Amino acid sequence

>lcl|BSEQ0019580|Glycosyltransferase 6 domain-containing protein 1
MNSKRMLLLVLFAFSLMLVERYFRNHQVEELRLSDWFHPRKRPDVITKTDWLAPVLWEGT
FDRRVLEKHYRRRNITVGLAVFATGRFAEEYLRPFLHSANKHFMTGYRVIFYIMVDAFFK
LPDIEPSPLRTFKAFKVGTERWWLDGPLVHVKSLGEHIASHIQDEVDFLFSMAANQVFQN
EFGVETLGPLVAQLHAWWYFRNTKNFPYERRPTSAACIPFGQGDFYYGNLMVGGTPHNIL
DFIKEYLNGVIHDIKNGLNSTYEKHLNKYFYLNKPTKLLSPAYSWDLAFSPPPQIQYVKV
AHDSQRKL

Number of residues

308

Molecular Weight

36273.575

Theoretical pI

Not Available

GO Classification

Functions

transferase activity, transferring hexosyl groups

Processes

carbohydrate metabolic process

Components

integral component of membrane

General Function

Transferase activity, transferring hexosyl groups

Specific Function

Not Available

Pfam Domain Function

• Glyco_transf_6 (PF03414)

Transmembrane Regions

7-23

Cellular Location

Membrane

Gene sequence

>lcl|BSEQ0019581|Glycosyltransferase 6 domain-containing protein 1 (GLT6D1)
ATGAATTCTAAAAGAATGCTGTTATTGGTTTTATTTGCTTTTTCACTGATGTTGGTTGAG
CGTTATTTCAGGAATCACCAAGTAGAAGAACTTCGGCTCTCAGACTGGTTTCATCCTAGA
AAACGCCCTGATGTTATAACGAAAACAGACTGGCTCGCTCCTGTCCTATGGGAAGGGACT
TTCGACAGGCGGGTCCTGGAAAAACATTACAGAAGGCGGAATATCACTGTGGGCCTGGCC
GTCTTTGCTACTGGCAGGTTTGCAGAGGAGTACCTGAGGCCGTTCCTACACTCCGCAAAT
AAGCACTTCATGACAGGCTACCGAGTGATCTTCTACATCATGGTGGACGCCTTCTTCAAG
CTGCCTGACATAGAGCCCAGTCCTCTTCGAACGTTCAAAGCATTTAAAGTGGGCACCGAG
AGGTGGTGGCTCGATGGCCCCCTGGTGCATGTGAAGAGCCTGGGTGAACACATCGCCAGT
CACATCCAGGACGAGGTGGACTTCCTCTTCAGCATGGCTGCCAACCAGGTCTTCCAGAAT
GAGTTCGGGGTGGAGACCCTGGGCCCGTTGGTGGCCCAGCTCCACGCCTGGTGGTATTTC
AGAAACACCAAGAACTTCCCTTATGAGAGGAGGCCGACCTCAGCAGCTTGCATCCCGTTT
GGACAGGGAGATTTCTATTATGGCAACTTGATGGTTGGTGGCACACCCCATAATATTTTA
GACTTCATCAAAGAATATCTGAACGGAGTTATTCATGACATCAAAAATGGACTCAATAGC
ACTTATGAAAAGCACCTTAACAAATATTTTTACCTCAATAAACCCACCTAG

Chromosome Location

9

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q7Z4J2
UniProtKB Entry Name	GL6D1_HUMAN
HGNC ID	HGNC:23671

General References

1. Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blocker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I: DNA sequence and analysis of human chromosome 9. Nature. 2004 May 27;429(6990):369-74. [Article]
2. Schaefer AS, Richter GM, Nothnagel M, Manke T, Dommisch H, Jacobs G, Arlt A, Rosenstiel P, Noack B, Groessner-Schreiber B, Jepsen S, Loos BG, Schreiber S: A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis. Hum Mol Genet. 2010 Feb 1;19(3):553-62. doi: 10.1093/hmg/ddp508. Epub 2009 Nov 6. [Article]
3. Casals F, Ferrer-Admetlla A, Sikora M, Ramirez-Soriano A, Marques-Bonet T, Despiau S, Roubinet F, Calafell F, Bertranpetit J, Blancher A: Human pseudogenes of the ABO family show a complex evolutionary dynamics and loss of function. Glycobiology. 2009 Jun;19(6):583-91. doi: 10.1093/glycob/cwp017. Epub 2009 Feb 13. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB03435	Uridine-5'-Diphosphate	experimental	unknown		Details
DB03685	Uridine monophosphate	experimental	unknown		Details
DB02379	Beta-D-Glucose	experimental	unknown		Details
DB01861	Uridine diphosphate glucose	experimental	unknown		Details
DB04465	Lactose	approved, experimental, investigational	unknown		Details