1-deoxypentalenic acid 11-beta-hydroxylase

Details

Name
1-deoxypentalenic acid 11-beta-hydroxylase
Synonyms
  • 1.14.11.35
  • Neopentalenolactone biosynthesis protein H
Gene Name
ptlH
Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Amino acid sequence
>lcl|BSEQ0012617|1-deoxypentalenic acid 11-beta-hydroxylase
MTNVTGDYTDCTPLLGDRAALDSFYEEHGYLFLRNVLDRDLVKTVAEQMREGLVALGAAD
PHATLEELTIDSFESVDEVAMHDYVKYDAFWNNPSTIKVFEQVFGEPVFVFLSTTIRYYP
SQAGSEEPSFHYLTPFHQDGFYIGPNQDFRTFWIPLIRTTRESGGVALADGSHRRGKRDH
VLNESFRRFGHPVRGIPPTEVSEDEHLLHSPMEPGDILLFHAHMCHKSIPNLSKDPRLMR
MSMDTRVQPAKSHRGFNAMTPWTESAKDASKGIMAKITGTPTDVE
Number of residues
285
Molecular Weight
32264.03
Theoretical pI
5.68
GO Classification
Functions
iron ion binding / L-ascorbic acid binding / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Processes
antibiotic biosynthetic process / lactone biosynthetic process / oxidation-reduction process
General Function
Not Available
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0012618|1-deoxypentalenic acid 11-beta-hydroxylase (ptlH)
GTGACGAACGTGACTGGGGACTACACGGACTGCACTCCTCTGCTCGGCGACCGAGCGGCA
CTCGACAGCTTCTACGAGGAACACGGCTACTTATTCCTGCGGAACGTACTCGACCGTGAC
CTCGTCAAAACGGTGGCGGAGCAGATGCGGGAAGGACTCGTCGCGCTCGGTGCCGCGGAT
CCGCACGCCACGCTCGAGGAACTCACGATCGACTCCTTCGAGTCGGTCGACGAAGTGGCC
ATGCACGACTACGTCAAATACGACGCATTCTGGAACAACCCGTCGACCATCAAGGTTTTC
GAGCAGGTGTTCGGCGAGCCGGTATTCGTGTTCCTCTCCACGACCATCCGGTACTACCCG
TCGCAGGCGGGCTCCGAGGAGCCGTCCTTCCACTACCTGACGCCGTTTCACCAGGACGGC
TTCTACATAGGGCCCAACCAGGACTTTCGCACCTTCTGGATCCCCCTGATACGGACGACC
AGGGAGTCCGGAGGTGTCGCGCTGGCGGACGGCAGCCACCGGCGCGGAAAGCGCGACCAC
GTGCTCAACGAGTCCTTCCGCAGGTTCGGCCACCCGGTGCGCGGAATTCCGCCGACGGAG
GTGAGTGAGGACGAACACCTGCTGCACTCCCCCATGGAGCCGGGAGACATCCTCCTCTTT
CATGCGCACATGTGCCACAAATCAATTCCGAACCTGTCGAAGGACCCGCGCCTCATGCGG
ATGTCGATGGACACCCGGGTACAGCCCGCGAAATCCCACCGCGGCTTCAACGCAATGACG
CCCTGGACGGAATCGGCAAAGGACGCGTCAAAGGGAATCATGGCGAAGATCACCGGTACC
CCCACCGACGTGGAATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ82IZ1
UniProtKB Entry NamePTLH_STRAW
GenBank Protein ID29603637
GenBank Gene IDBA000030
General References
  1. Omura S, Ikeda H, Ishikawa J, Hanamoto A, Takahashi C, Shinose M, Takahashi Y, Horikawa H, Nakazawa H, Osonoe T, Kikuchi H, Shiba T, Sakaki Y, Hattori M: Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12215-20. Epub 2001 Sep 25. [Article]
  2. Ikeda H, Ishikawa J, Hanamoto A, Shinose M, Kikuchi H, Shiba T, Sakaki Y, Hattori M, Omura S: Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol. 2003 May;21(5):526-31. Epub 2003 Apr 14. [Article]
  3. You Z, Omura S, Ikeda H, Cane DE: Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlH, a non-heme iron dioxygenase of Streptomyces avermitilis. J Am Chem Soc. 2006 May 24;128(20):6566-7. [Article]
  4. Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE: Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone. Biochemistry. 2011 Mar 15;50(10):1739-54. doi: 10.1021/bi1019786. Epub 2011 Feb 8. [Article]
  5. You Z, Omura S, Ikeda H, Cane DE, Jogl G: Crystal structure of the non-heme iron dioxygenase PtlH in pentalenolactone biosynthesis. J Biol Chem. 2007 Dec 14;282(50):36552-60. Epub 2007 Oct 16. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB06903(1S,3aS,5aR,8aS)-1,7,7-trimethyl-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene-4-carboxylic acidexperimentalunknownDetails