Glutamate racemase
Details
- Name
- Glutamate racemase
- Synonyms
- 5.1.1.3
- Gene Name
- murI
- Organism
- Enterococcus faecalis (strain ATCC 700802 / V583)
- Amino acid sequence
>lcl|BSEQ0012881|Glutamate racemase MSNQEAIGLIDSGVGGLTVLKEALKQLPNERLIYLGDTARCPYGPRPAEQVVQFTWEMAD FLLKKRIKMLVIACNTATAVALEEIKAALPIPVVGVILPGARAAVKVTKNNKIGVIGTLG TIKSASYEIAIKSKAPTIEVTSLDCPKFVPIVESNQYRSSVAKKIVAETLQALQLKGLDT LILGCTHYPLLRPVIQNVMGSHVTLIDSGAETVGEVSMLLDYFDIAHTPEAPTQPHEFYT TGSAKMFEEIASSWLGIENLKAQQIHLGGNEND
- Number of residues
- 273
- Molecular Weight
- 29479.01
- Theoretical pI
- 6.36
- GO Classification
- Functionsglutamate racemase activityProcessescell wall organization / peptidoglycan biosynthetic process / regulation of cell shape
- General Function
- Glutamate racemase activity
- Specific Function
- Provides the (R)-glutamate required for cell wall biosynthesis.
- Pfam Domain Function
- Asp_Glu_race (PF01177)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012882|Glutamate racemase (murI) ATGAGCAATCAAGAAGCCATTGGATTAATTGATTCTGGCGTTGGTGGATTAACTGTTTTA AAGGAAGCGCTAAAACAATTACCAAATGAACGATTAATTTATTTAGGAGATACAGCCCGT TGCCCATATGGTCCACGACCAGCCGAACAAGTCGTTCAGTTTACTTGGGAAATGGCCGAT TTTTTATTGAAAAAACGAATAAAAATGCTAGTAATCGCATGTAATACCGCGACGGCTGTC GCATTAGAAGAAATTAAAGCTGCCTTGCCAATTCCAGTTGTCGGTGTTATTTTACCTGGC GCACGAGCAGCCGTTAAAGTCACAAAAAATAACAAGATTGGTGTCATAGGTACGTTAGGG ACAATCAAAAGTGCTTCCTATGAAATCGCCATTAAAAGTAAGGCACCAACAATTGAGGTG ACTAGTTTAGATTGCCCTAAATTTGTCCCCATTGTTGAAAGTAATCAATATCGTTCTTCC GTAGCAAAAAAAATTGTGGCAGAAACACTTCAAGCACTACAATTAAAAGGACTTGATACG TTGATTTTAGGTTGTACCCATTACCCGTTGTTACGTCCGGTGATTCAAAATGTGATGGGG AGTCATGTGACATTAATTGACTCAGGAGCCGAAACAGTTGGCGAAGTCAGCATGCTTCTC GATTATTTTGACATTGCCCACACGCCTGAAGCGCCTACACAGCCCCATGAATTTTATACA ACTGGTTCTGCAAAAATGTTTGAAGAGATTGCAAGCAGTTGGCTTGGTATAGAGAACTTA AAAGCACAACAGATTCACTTAGGAGGAAACGAAAATGATTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q836J0 UniProtKB Entry Name MURI_ENTFA GenBank Protein ID 29342120 GenBank Gene ID AE016830 - General References
- Paulsen IT, Banerjei L, Myers GS, Nelson KE, Seshadri R, Read TD, Fouts DE, Eisen JA, Gill SR, Heidelberg JF, Tettelin H, Dodson RJ, Umayam L, Brinkac L, Beanan M, Daugherty S, DeBoy RT, Durkin S, Kolonay J, Madupu R, Nelson W, Vamathevan J, Tran B, Upton J, Hansen T, Shetty J, Khouri H, Utterback T, Radune D, Ketchum KA, Dougherty BA, Fraser CM: Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science. 2003 Mar 28;299(5615):2071-4. [Article]
- Lundqvist T, Fisher SL, Kern G, Folmer RH, Xue Y, Newton DT, Keating TA, Alm RA, de Jonge BL: Exploitation of structural and regulatory diversity in glutamate racemases. Nature. 2007 Jun 14;447(7146):817-22. [Article]
- Geng B, Breault G, Comita-Prevoir J, Petrichko R, Eyermann C, Lundqvist T, Doig P, Gorseth E, Noonan B: Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4368-72. doi: 10.1016/j.bmcl.2008.06.068. Epub 2008 Jun 24. [Article]