Synaptic vesicular amine transporter
Details
- Name
- Synaptic vesicular amine transporter
- Synonyms
- Monoamine transporter
- Solute carrier family 18 member 2
- VAT2
- Vesicular amine transporter 2
- Vmat2
- Gene Name
- Slc18a2
- Organism
- Mouse
- Amino acid sequence
>lcl|BSEQ0052032|Synaptic vesicular amine transporter MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNTTEI QTARPALTASTSESFHSIFSYYNNSTVFTGNATGGLPGGESPKATTTQHTVTNTTVPPDC PSEDKDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFA FSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPP FGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIA AGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGR WLCALLGMIVVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSV YGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIVFAPLCFFLRSPPAKE EKMAILMDHNCPIKTKMYTQNNVQPYPVGDDEESESD
- Number of residues
- 517
- Molecular Weight
- 55753.05
- Theoretical pI
- Not Available
- GO Classification
- Functionsamine transmembrane transporter activity / drug binding / drug transmembrane transporter activity / enzyme binding / heat shock protein binding / monoamine transmembrane transporter activity / serotoninProcessesaging / aminergic neurotransmitter loading into synaptic vesicle / cellular response to drug / glucose homeostasis / insulin secretion / locomotory behavior / monoamine transport / negative regulation of neurotransmitter transport / neurotransmitter loading into synaptic vesicle / neurotransmitter transport / post-embryonic development / response to amphetamine / response to toxic substanceComponentsaxon terminus / cell body / cell projection / cytoplasm / dense core granule / dopaminergic synapse / integral component of neuronal dense core vesicle membrane / integral component of synaptic vesicle membrane / neuron projection / neuronal cell body / neuronal dense core vesicle / postsynapse / synaptic vesicle / synaptic vesicle membrane / terminal bouton
- General Function
- Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis (By similarity).
- Specific Function
- Amine transmembrane transporter activity
- Pfam Domain Function
- MFS_1 (PF07690)
- Transmembrane Regions
- 21-41 133-153 163-183 193-213 223-245 252-274 295-314 332-355 361-381 393-413 418-438 444-465
- Cellular Location
- Cytoplasmic vesicle membrane
- Gene sequence
>lcl|BSEQ0052033|Synaptic vesicular amine transporter (Slc18a2) ATGGCCCTGAGCGATCTGGTGCTGCTGCGATGGCTGCGGGACAGCCGCCACTCGCGCAAG CTGATCCTGTTCATCGTGTTCCTCGCGCTGCTGCTAGACAACATGCTGCTCACCGTCGTA GTTCCCATCATTCCCAGCTACCTGTACAGCATTAAGCACGAGAAAAATACTACGGAAATC CAGACTGCCAGGCCAGCGCTCACAGCCTCCACTTCCGAAAGCTTCCACAGCATCTTCTCT TACTATAACAACTCTACTGTGTTCACGGGGAATGCCACGGGGGGCCTCCCAGGAGGGGAG TCACCCAAGGCTACCACCACACAGCACACTGTGACCAACACGACTGTCCCTCCCGACTGC CCCAGTGAAGACAAAGACCTTCTAAATGAGAATGTGCAAGTTGGGCTGCTGTTTGCCTCC AAAGCCACTGTCCAGCTCCTCACCAACCCATTCATAGGACTTCTAACCAACAGAATTGGC TATCCAATTCCCATGTTTGCTGGATTCTGCATTATGTTTATCTCAACAGTTATGTTTGCC TTCTCCAGCAGCTATGCCTTCCTGCTGATCGCCAGGTCCCTGCAGGGAATCGGCTCCTCT TGCTCATCTGTGGCTGGGATGGGCATGCTGGCCAGCGTGTACACAGATGATGAAGAGAGG GGTAACGCCATGGGGATTGCTCTGGGGGGCCTGGCCATGGGGGTCTTAGTGGGACCCCCC TTTGGAAGTGTGCTCTATGAGTTTGTGGGGAAGACAGCTCCTTTCCTGGTGCTTGCTGCC TTGGTGCTCTTGGATGGAGCTATTCAGCTCTTTGTGCTCCAGCCATCCCGAGTGCAGCCA GAAAGTCAGAAGGGGACACCTCTTACGACCTTGCTGAAGGACCCATACATTCTCATCGCT GCAGGCTCCATCTGCTTTGCAAACATGGGGATAGCCATGCTGGAGCCCGCCCTGCCCATC TGGATGATGGAGACCATGTGTTCCCGAAAGTGGCAGCTGGGCGTTGCCTTCCTGCCAGCG AGCATCTCTTATCTCATTGGAACCAATATTTTTGGGATACTTGCACACAAAATGGGAAGG TGGCTGTGTGCTCTTCTGGGAATGATAGTTGTTGGGATCAGCATTTTATGTATTCCTTTT GCAAAAAATATCTACGGACTCATCGCTCCCAACTTTGGAGTTGGTTTTGCCATTGGGATG GTGGACTCCTCCATGATGCCTATCATGGGCTACCTGGTGGACCTGCGGCACGTGTCTGTC TATGGGAGTGTGTATGCCATTGCAGATGTAGCCTTCTGCATGGGGTATGCTATCGGTCCC TCTGCTGGTGGTGCTATTGCAAAGGCAATTGGCTTTCCTTGGCTCATGACAATTATTGGG ATAATTGATATTGTTTTTGCTCCACTCTGCTTTTTTCTTCGAAGTCCACCTGCTAAGGAA GAAAAAATGGCTATCCTCATGGACCACAACTGCCCCATTAAGACAAAGATGTACACTCAG AATAATGTCCAGCCGTACCCCGTCGGTGATGATGAAGAATCTGAGAGTGACTGA
- Chromosome Location
- 19
- Locus
- 19 54.64 cM
- External Identifiers
Resource Link UniProtKB ID Q8BRU6 UniProtKB Entry Name VMAT2_MOUSE - General References
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