UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Details

Name
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Synonyms
  • 6.3.2.10
  • D-alanyl-D-alanine-adding enzyme
Gene Name
murF
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Amino acid sequence
>lcl|BSEQ0022438|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
MKLTIHEIAQVVGAKNDISIFEDTQLEKAEFDSRLIGTGDLFVPLKGARDGHDFIETAFE
NGAAVTLSEKEVSNHPYILVDDVLTAFQSLASYYLEKTTVDVFAVTGSNGKTTTKDMLAH
LLSTRYKTYKTQGNYNNEIGLPYTVLHMPEGTEKLVLEMGQDHLGDIHLLSELARPKTAI
VTLVGEAHLAFFKDRSEIAKGKMQIADGMASGSLLLAPADPIVEDYLPIDKKVVRFGQGA
ELEITDLVERKDSLTFKANFLEQALDLPVTGKYNATNAMIASYVALQEGVSEEQIRLAFQ
HLELTRNRTEWKKAANGADILSDVYNANPTAMKLILETFSAIPANEGGKKIAVLADMKEL
GDQSVQLHNQMILSLSPDVLDIVIFYGEDIAQLAQLASQMFPIGHVYYFKKTEDQDQFED
LVKQVKESLGAHDQILLKGSNSMNLAKLVESLENEDK
Number of residues
457
Molecular Weight
50502.04
Theoretical pI
4.64
GO Classification
Functions
ATP binding / UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity / UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
Processes
cell cycle / cell division / cell wall organization / peptidoglycan biosynthetic process / regulation of cell shape
Components
cytoplasm
General Function
Udp-n-acetylmuramoylalanyl-d-glutamyl-2,6-diaminopimelate-d-alanyl-d-alanine ligase activity
Specific Function
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0022439|UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (murF)
ATGAAATTAACAATCCATGAAATTGCCCAAGTTGTTGGAGCCAAAAATGATATCAGTATC
TTTGAGGACACTCAGTTAGAAAAAGCTGAGTTTGATAGTCGTTTGATTGGAACTGGAGAT
TTATTTGTGCCACTTAAAGGTGCGCGTGATGGCCATGACTTTATTGAAACAGCCTTTGAA
AATGGTGCAGCAGTAACCTTGTCTGAGAAAGAGGTCTCAAATCATCCTTACATTTTAGTA
GATGATGTTTTGACAGCCTTTCAATCCCTAGCATCCTACTATCTTGAAAAAACGACTGTT
GATGTCTTTGCTGTTACAGGTTCAAATGGCAAGACAACGACTAAGGATATGTTGGCGCAT
TTACTGTCAACAAGATACAAGACCTACAAAACACAAGGCAATTACAATAATGAGATTGGC
CTTCCTTACACAGTTCTTCATATGCCTGAAGGAACAGAAAAGTTGGTTTTGGAGATGGGA
CAGGATCACTTGGGAGATATTCATCTCTTGTCTGAATTGGCTCGTCCAAAAACAGCCATC
GTGACCTTGGTTGGAGAAGCTCATTTGGCCTTTTTCAAAGATCGTTCTGAGATTGCTAAA
GGAAAAATGCAAATTGCAGACGGAATGGCTTCAGGTTCCTTGCTTTTAGCGCCGGCTGAC
CCTATCGTAGAGGACTATTTGCCAATTGATAAAAAGGTGGTTCGTTTTGGTCAAGGAGCA
GAGCTGGAAATTACTGACTTGGTTGAGCGTAAGGACAGTCTGACCTTTAAGGCTAATTTC
TTGGAACAAGCCCTTGATTTGCCAGTAACTGGCAAGTACAATGCGACAAATGCTATGATT
GCATCCTATGTTGCCTTGCAAGAAGGAGTTTCAGAGGAGCAAATTCGTTTGGCATTCCAA
CATCTTGAATTGACGCGTAACCGTACCGAGTGGAAGAAAGCAGCCAATGGAGCAGATATC
CTGTCAGATGTTTACAATGCCAATCCAACTGCTATGAAACTGATTTTAGAGACTTTCTCT
GCCATTCCAGCCAATGAAGGTGGCAAGAAAATTGCAGTGTTGGCGGATATGAAGGAGCTT
GGTGACCAGTCTGTTCAACTTCATAATCAGATGATTTTGAGCCTCTCCCCAGATGTGCTT
GATATCGTTATTTTCTATGGAGAAGATATTGCTCAGTTGGCTCAATTGGCCAGTCAAATG
TTCCCAATCGGCCACGTTTACTACTTCAAGAAAACAGAAGACCAGGATCAATTTGAAGAC
CTAGTCAAGCAGGTCAAGGAAAGCCTTGGAGCCCATGACCAAATCCTGCTCAAAGGCTCT
AACTCTATGAATCTAGCCAAGTTGGTAGAAAGTTTAGAAAATGAAGACAAGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ8DNV6
UniProtKB Entry NameQ8DNV6_STRR6
GenBank Protein ID15457529
GenBank Gene IDAE007317
General References
  1. Hoskins J, Alborn WE Jr, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR Jr, Skatrud PL, Glass JI: Genome of the bacterium Streptococcus pneumoniae strain R6. J Bacteriol. 2001 Oct;183(19):5709-17. [Article]
  2. Longenecker KL, Stamper GF, Hajduk PJ, Fry EH, Jakob CG, Harlan JE, Edalji R, Bartley DM, Walter KA, Solomon LR, Holzman TF, Gu YG, Lerner CG, Beutel BA, Stoll VS: Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure. Protein Sci. 2005 Dec;14(12):3039-47. [Article]
  3. Hrast M, Turk S, Sosic I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S: Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF. Eur J Med Chem. 2013 Aug;66:32-45. doi: 10.1016/j.ejmech.2013.05.013. Epub 2013 May 21. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB069702-CHLORO-N-(3-CYANO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHEN-2-YL)-5-DIETHYLSULFAMOYL-BENZAMIDEexperimentalunknownDetails