MIO-dependent tyrosine 2,3-aminomutase

Details

Name
MIO-dependent tyrosine 2,3-aminomutase
Synonyms
  • 5.4.3.6
  • Tyrosine ammonia-lyase
Gene Name
Not Available
Organism
Streptomyces globisporus
Amino acid sequence
>lcl|BSEQ0012622|MIO-dependent tyrosine 2,3-aminomutase
MALTQVETEIVPVSVDGETLTVEAVRRVAEERATVDVPAESIAKAQKSREIFEGIAEQNI
PIYGVTTGYGEMIYMQVDKSKEVELQTNLVRSHSAGVGPLFAEDEARAIVAARLNTLAKG
HSAVRPIILERLAQYLNEGITPAIPEIGSLGASGDLAPLSHVASTLIGEGYVLRDGRPVE
TAQVLAERGIEPLELRFKEGLALINGTSGMTGLGSLVVGRALEQAQQAEIVTALLIEAVR
GSTSPFLAEGHDIARPHEGQIDTAANMRALMRGSGLTVEHADLRRELQKDKEAGKDVQRS
EIYLQKAYSLRAIPQVVGAVRDTLYHARHKLRIELNSANDNPLFFEGKEIFHGANFHGQP
IAFAMDFVTIALTQLGVLAERQINRVLNRHLSYGLPEFLVSGDPGLHSGFAGAQYPATAL
VAENRTIGPASTQSVPSNGDNQDVVSMGLISARNARRVLSNNNKILAVEYLAAAQAVDIS
GRFDGLSPAAKATYEAVRRLVPTLGVDRYMADDIELVADALSRGEFLRAIARETDIQLR
Number of residues
539
Molecular Weight
58138.44
Theoretical pI
5.4
GO Classification
Functions
tyrosine 2,3-aminomutase activity / tyrosine ammonia-lyase activity
Processes
antibiotic biosynthetic process / toxin biosynthetic process
General Function
Tyrosine ammonia-lyase activity
Specific Function
Involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. Catalyzes the MIO-dependent deamination of L-tyrosine generating the corresponding alpha,beta-unsaturated acid, (S)-beta-tyrosine.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm (By similarity)
Gene sequence
>lcl|BSEQ0007206|1497 bp
GTGAGGGCTCTGCCGGGAAGTGGCGGATTGCGCATGGCAGGAGATGCCCCGACAGCGGCC
GGGAATCGACGATGTCCCCCGACCCCTATCCAGCGTCCGCTGATCCTCAGGAGGCAGACC
TTGCAGGCTCCAGAAGCGAAGAACGGCCGGTCCCCGGAGCAGCCGCAGGAAGAGCGGATC
GTCCTGGACGTATGGCTGGCGAACTACCCGTTCCCCACCTATGACGGGCGTGACTTCCTC
GCTCCGCTGCGCGAGCGGGCGGCGGAGTTCGAGCGCGCCCACCCCCGATACCGGGTCGAC
ATCAACGGCCACGACTTCTGGACCATCCCCGAGAAGGTGGCGCGCGCCACCGCGGAGGGC
AGGCCTCCGCACATAGCGGGCTACTACGCCACCGACAGCCAGTTGGCGCGGGACGCGCGC
AGGCCCGACGGGAAGCCGGTCTTCACCTCGGTGGAGGCCGCGTTGGCCGGCCGGACGGAG
ATACTGGGACACCCGGTGGTGGTGGAGGACCTCGACCCCGTGGTGCGCGACTCCTACTCG
TTCGGGGGCGAGTTGGTGTCGCTGCCGCTCACGGTCACCACCATGCTCTGCTACGCCAAC
TCCTCCCTCCTCGCGCGCGCCGGTGTTCCGGAGTTGCCCCGTACCTGGGATGAGGTCGAA
GCAGCCTGCCAGGCGGTGGCCAGCGTCGACGGGGGGCCCGGTCACGGAATCACCTGGGCC
AACGACGGCTGGGTTTTCCAGCAGGCCGTCGCCCTTCAGAACGGGGTGCTGACCGATCAG
GACAACGGCCGCTCCGGCTCCGCCACGACGGTGGACGTCACATCGGACGAGATGCTGGAC
TGGGTCCGCTGGTGGACGCACCTCCATGAGCGCGGCCATTACCTCTACACGGGCGGGCCC
TCGGACTGGGGCGGGGCGTTCGAGGCTTTCGTCCAGCAGAAGGTCGCATTCACCTTCGAC
TCGTCCAAGGCCGCCCGGGAACTCATCCAGGCCGGTGCACAGGCCGGTTTCGAGGTCGCG
GTGTTCCCGTTGCCCAGGAACGCGAAGGCCCCGGTAGCGGGCCAGCCCGTCTCGGGAGAC
TCCCTGTGGCTGGCCGCGGGACTCGACGAGACCACGCAGGACGGGCTGCTCGCTCTCACC
CAGTACCTGATCAGCCCGGCCAACGCCGCGGACTGGCACCGCACCAACGGTTTCGTACCG
GTGACCGGCGCGGCCGGGGAACTGCTGGAAGCGACAGGCTGGTTCGACCGCCGGCCGCAG
CAACGGGTGGCCGGGGAGCAGTTGAAGGCGTCCGACCGGTCACCGGCGGCGCTCGGCGCG
CTGCTCGGCGACTTCGCGGCCGTCAACGAGGTCATCACCGCAGCGATGGACGATGTCCTG
CGCAGTGGAGCGGACCCCGCGAAGGCCTTCGCCGAAGCCGGCGTGGCCGCCCAGCAACTG
CTCGATGCCTACAACGCCCGGAACCGCTCCGGATCCGGGACCCCCTCCGCCGTCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ8GMG0
UniProtKB Entry NameTAM_STRGL
GenBank Protein ID24575077
GenBank Gene IDAY048670
General References
  1. Liu W, Christenson SD, Standage S, Shen B: Biosynthesis of the enediyne antitumor antibiotic C-1027. Science. 2002 Aug 16;297(5584):1170-3. [Article]
  2. Christianson CV, Montavon TJ, Van Lanen SG, Shen B, Bruner SD: The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway. Biochemistry. 2007 Jun 19;46(24):7205-14. Epub 2007 May 22. [Article]
  3. Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD: Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM. Bioorg Med Chem Lett. 2008 May 15;18(10):3099-102. Epub 2007 Nov 19. [Article]
  4. Cooke HA, Bruner SD: Probing the active site of MIO-dependent aminomutases, key catalysts in the biosynthesis of beta-amino acids incorporated in secondary metabolites. Biopolymers. 2010 Sep;93(9):802-10. doi: 10.1002/bip.21500. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB06946(2S,3S)-3-(4-fluorophenyl)-2,3-dihydroxypropanoic acidexperimentalunknownDetails