Calcium-dependent protein kinase 4

Details

Name
Calcium-dependent protein kinase 4
Synonyms
  • 2.7.11.1
  • CDPK4
Gene Name
CPK4
Organism
Plasmodium falciparum (isolate 3D7)
Amino acid sequence
>lcl|BSEQ0051515|Calcium-dependent protein kinase 4
MGQEVSSVNNTKNEHHKTNKKSLKGGNERHEMKESSVGISKKIVENSFNNSKLRPGMFIQ
NSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVE
LLKMLDHINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARIIKQILSG
ITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAP
DVLHGTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDK
AKDLIKKMLMYTSAVRISARDALEHEWIKMMTSKDNLNIDIPSLELSIANIRQFQSTQKL
AQAALLYMGSKLTTIDETKELTKIFKKMDKNGDGQLDRNELIIGYKELLKLKGEDTSDLD
NAAIEYEVDQILNSIDLDQNGYIEYSEFLTVSIDRKLLLSTERLEKAFKLFDKDGSGKIS
ANELAQLFGLSDVSSECWKTVLKEVDQNNDGEIDFKEFRDMLVKLCNY
Number of residues
528
Molecular Weight
60779.205
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / calcium ion binding / calcium-dependent protein serine/threonine kinase activity / calcium-dependent protein serine/threonine phosphatase activity / calmodulin binding / calmodulin-dependent protein kinase activity / catalytic activity
Processes
cell differentiation / intracellular signal transduction / multicellular organism development / peptidyl-serine phosphorylation / protein autophosphorylation / protein phosphorylation
Components
cytoplasm / nucleus
General Function
Calcium-dependent kinase that plays a central role in the sexual reproduction and mosquito transmission of P.falciparum. Required for cell cycle progression in the male gametocyte, an essential step in parasite transmission to the mosquito (By similarity).
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051516|Calcium-dependent protein kinase 4 (CPK4)
ATGGGACAAGAGGTATCGAGTGTTAACAACACAAAAAATGAACACCATAAAACAAATAAG
AAAAGTTTGAAAGGGGGTAATGAGAGACATGAAATGAAAGAGAGTAGTGTAGGTATATCT
AAGAAAATCGTAGAGAATAGTTTTAATAATAGTAAATTAAGACCTGGTATGTTTATACAG
AATAGTAATGTTGTATTTAATGAACAATATAAAGGAATAAAAATATTGGGTAAAGGTTCT
TTTGGTGAGGTGATACTTAGTAGGGATAAACATACTGGTCATGAGTATGCAATAAAAGTT
ATTAGCAAAAAACATGTTAAAAGAAAAACTGATAAAGAAAGTTTATTAAGAGAAGTAGAG
TTATTAAAAATGTTAGATCATATTAATATAATGAAATTATATGAATTTTTTGAAGATAAT
AATTATTATTATTTAGTGTCTGATGTATATACAGGAGGAGAATTATTTGATGAAATTATT
AGTAGAAAGAGATTTTATGAAATAGATGCAGCAAGAATTATTAAACAAATTTTAAGTGGA
ATTACATATATGCATAAAAATAATGTTGTTCATAGAGATTTAAAACCAGAAAATATTTTA
TTAGAAACTAAAAATAAAGAAGATATGATAATTAAAATTATCGACTTTGGATTATCTACA
CATTTTGAATATAGTAAAAAAATGAAAGACAAAATAGGAACTGCTTATTATATTGCTCCA
GATGTATTACATGGTACATACGACGAAAAATGTGATATCTGGTCATGTGGAGTGATCCTC
TACATACTTCTCTCAGGGTGCCCCCCTTTCAACGGGTCGAACGAATACGATATTTTAAAA
AAAGTGGAAGCGGGGAAATATACATTCGATTTACCACAATTCAAAAAAATTAGTGATAAG
GCAAAAGACTTAATAAAAAAAATGCTCATGTATACGAGTGCTGTTAGGATATCGGCAAGG
GACGCACTAGAACATGAGTGGATAAAAATGATGACAAGCAAAGATAACTTAAATATAGAT
ATTCCGTCCTTAGAATTGAGTATAGCAAATATCAGACAATTTCAAAGTACCCAGAAGTTA
GCTCAAGCAGCTTTATTATATATGGGTTCCAAATTAACAACAATTGATGAAACAAAAGAA
TTAACAAAAATTTTTAAAAAGATGGATAAAAATGGTGATGGTCAATTAGATAGAAATGAA
CTCATAATAGGATACAAAGAATTATTAAAACTTAAAGGAGAAGATACAAGTGATTTAGAT
AATGCTGCTATCGAATATGAAGTTGATCAAATCTTGAATTCTATAGATTTAGATCAAAAT
GGATATATTGAATATTCTGAATTTTTAACAGTTTCTATTGATCGAAAACTTTTATTATCA
ACTGAAAGATTAGAAAAAGCCTTCAAATTATTTGATAAAGATGGGTCAGGTAAAATATCA
GCAAATGAATTAGCTCAATTATTTGGACTTAGTGATGTCAGCTCAGAATGTTGGAAAACC
GTCCTTAAAGAAGTGGATCAAAATAATGATGGAGAAATCGACTTTAAAGAATTTAGGGAT
ATGCTAGTCAAACTTTGTAATTATTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ8IBS5
UniProtKB Entry NameCDPK4_PLAF7
General References
  1. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. [Article]
  2. Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG: Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature. 2002 Oct 3;419(6906):527-31. [Article]
  3. Lasonder E, Ishihama Y, Andersen JS, Vermunt AM, Pain A, Sauerwein RW, Eling WM, Hall N, Waters AP, Stunnenberg HG, Mann M: Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry. Nature. 2002 Oct 3;419(6906):537-42. doi: 10.1038/nature01111. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails