Zinc transporter 8
Details
- Name
- Zinc transporter 8
- Synonyms
- Solute carrier family 30 member 8
- ZnT-8
- ZNT8
- Gene Name
- SLC30A8
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052355|Zinc transporter 8 MEFLERTYLVNDKAAKMYAFTLESVELQQKPVNKDQCPRERPEELESGGMYHCHSGSKPT EKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFS LWLSSKPPSKRLTFGWHRAEILGALLSILCIWVVTGVLVYLACERLLYPDYQIQATVMII VSSCAVAANIVLTVVLHQRCLGHNHKEVQANASVRAAFVHALGDLFQSISVLISALIIYF KPEYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSV HSLHIWSLTMNQVILSAHVATAASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQDPD CLFCEDPCD
- Number of residues
- 369
- Molecular Weight
- 40754.16
- Theoretical pI
- Not Available
- GO Classification
- Functionsprotein homodimerization activity / zinc ion binding / zinc ion transmembrane transporter activityProcessescellular zinc ion homeostasis / insulin secretion / positive regulation of insulin secretion / regulation of sequestering of zinc ion / regulation of vesicle-mediated transport / response to glucose / response to interferon-gamma / response to interleukin-1 / response to zinc ion / sequestering of zinc ion / zinc ion transmembrane transport / zinc ion transportComponentscell / cytoplasmic vesicle / integral component of membrane / membrane / plasma membrane / secretory granule / secretory granule membrane / transport vesicle membrane
- General Function
- Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.
- Specific Function
- Protein homodimerization activity
- Pfam Domain Function
- Cation_efflux (PF01545)
- Transmembrane Regions
- 80-100 104-124 141-161 176-196 218-238 246-266
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052356|Zinc transporter 8 (SLC30A8) ATGGAGTTTCTTGAAAGAACGTATCTTGTGAATGATAAAGCTGCCAAGATGTATGCTTTC ACACTAGAAAGTGTGGAACTCCAACAGAAACCGGTGAATAAAGATCAGTGTCCCAGAGAG AGACCAGAGGAGCTGGAGTCAGGAGGCATGTACCACTGCCACAGTGGCTCCAAGCCCACA GAAAAGGGGGCGAATGAGTACGCCTATGCCAAGTGGAAACTCTGTTCTGCTTCAGCAATA TGCTTCATTTTCATGATTGCAGAGGTCGTGGGTGGGCACATTGCTGGGAGTCTTGCTGTT GTCACAGATGCTGCCCACCTCTTAATTGACCTGACCAGTTTCCTGCTCAGTCTCTTCTCC CTGTGGTTGTCATCGAAGCCTCCCTCTAAGCGGCTGACATTTGGATGGCACCGAGCAGAG ATCCTTGGTGCCCTGCTCTCCATCCTGTGCATCTGGGTGGTGACTGGCGTGCTAGTGTAC CTGGCATGTGAGCGCCTGCTGTATCCTGATTACCAGATCCAGGCGACTGTGATGATCATC GTTTCCAGCTGCGCAGTGGCGGCCAACATTGTACTAACTGTGGTTTTGCACCAGAGATGC CTTGGCCACAATCACAAGGAAGTACAAGCCAATGCCAGCGTCAGAGCTGCTTTTGTGCAT GCCCTTGGAGATCTATTTCAGAGTATCAGTGTGCTAATTAGTGCACTTATTATCTACTTT AAGCCAGAGTATAAAATAGCCGACCCAATCTGCACATTCATCTTTTCCATCCTGGTCTTG GCCAGCACCATCACTATCTTAAAGGACTTCTCCATCTTACTCATGGAAGGTGTGCCAAAG AGCCTGAATTACAGTGGTGTGAAAGAGCTTATTTTAGCAGTCGACGGGGTGCTGTCTGTG CACAGCCTGCACATCTGGTCTCTAACAATGAATCAAGTAATTCTCTCAGCTCATGTTGCT ACAGCAGCCAGCCGGGACAGCCAAGTGGTTCGGAGAGAAATTGCTAAAGCCCTTAGCAAA AGCTTTACGATGCACTCACTCACCATTCAGATGGAATCTCCAGTTGACCAGGACCCCGAC TGCCTTTTCTGTGAAGACCCCTGTGACTAG
- Chromosome Location
- 8
- Locus
- 8q24.11
- External Identifiers
Resource Link UniProtKB ID Q8IWU4 UniProtKB Entry Name ZNT8_HUMAN HGNC ID HGNC:20303 - General References
- Chimienti F, Devergnas S, Favier A, Seve M: Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes. 2004 Sep;53(9):2330-7. doi: 10.2337/diabetes.53.9.2330. [Article]
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