Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Details
- Name
- Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
- Synonyms
- 2.1.1.57
- Cap methyltransferase 1
- Cap1 2'O-ribose methyltransferase 1
- FtsJ methyltransferase domain-containing protein 2
- FTSJD2
- hMTr1
- Interferon-stimulated gene 95 kDa protein
- ISG95
- KIAA0082
- MTR1
- Gene Name
- CMTR1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049708|Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 MKRRTDPECTAPIKKQKKRVAELALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGK QHSSDSFDDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFREGEGLGKYSQGRKDIVEAS SQKGRRGLGLTLRGFDQELNVDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKR KMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKM ANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGM TLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENISAFRNFVLDNTDRKGVHF LMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLL YCCFERVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLV VPLEVIKGDHEFTDYMIRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWG IPDQARVAPSSSDPKSKFFELIQGTEIDIFSYKPTLLTSKTLEKIRPVFDYRCMVSGSEQ KFLIGLGKSQIYTWDGRQSDRWIKLDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHI LDVLVLNGTDVREQHFNQRIQLAEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLE MKIIKGSSGTPKLSYTGRDDRHFVPMGLYIVRTVNEPWTMGFSKSFKKKFFYNKKTKDST FDLPADSIAPFHICYYGRLFWEWGDGIRVHDSQKPQDQDKLSKEDVLSFIQMHRA
- Number of residues
- 835
- Molecular Weight
- 95319.96
- Theoretical pI
- Not Available
- GO Classification
- FunctionsmRNA (nucleoside-2'-O-)-methyltransferase activity / nucleic acid bindingProcesses7-methylguanosine mRNA capping / cap1 mRNA methylation / mRNA methylationComponentscytosol / nucleoplasm / nucleus
- General Function
- S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
- Specific Function
- Mrna (nucleoside-2'-o-)-methyltransferase activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0049709|Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (CMTR1) ATGAAGAGGAGAACTGACCCAGAATGCACTGCCCCCATCAAGAAACAGAAAAAAAGAGTT GCAGAGCTTGCCCTGAGCCTCAGCTCCACGTCCGATGATGAACCTCCCTCCTCTGTCAGT CATGGAGCAAAAGCATCTACTACAAGCCTTAGTGGGTCTGATAGTGAGACCGAGGGGAAA CAACACAGCTCTGACTCTTTTGACGATGCATTCAAAGCAGACTCTCTTGTGGAAGGAACT TCTTCTCGCTATTCCATGTATAATAGCGTCTCCCAGAAGCTTATGGCCAAGATGGGCTTC AGGGAAGGTGAAGGATTGGGTAAATACAGCCAGGGTCGGAAGGACATCGTTGAGGCTTCC AGTCAGAAAGGTCGAAGAGGCTTGGGTCTGACACTCCGGGGCTTTGACCAGGAGCTGAAC GTGGACTGGCGAGATGAGCCAGAGCCCAGTGCTTGTGAGCAGGTGTCATGGTTTCCAGAA TGTACCACTGAAATTCCTGACACTCAGGAAATGAGCGATTGGATGGTGGTGGGAAAGAGA AAGATGATTATTGAAGATGAAACAGAGTTTTGTGGGGAAGAGCTGCTTCACAGTGTGTTG CAGTGTAAGAGCGTGTTTGATGTCTTGGATGGGGAAGAGATGCGGCGAGCTCGGACTCGG GCCAATCCCTATGAGATGATCCGAGGAGTCTTCTTTCTAAACAGGGCAGCAATGAAGATG GCTAACATGGATTTTGTATTTGATCGCATGTTCACAAATCCGCGGGACTCTTATGGGAAG CCACTGGTGAAGGACCGGGAAGCTGAGCTTCTGTACTTTGCTGATGTCTGCGCAGGCCCA GGTGGCTTCTCAGAGTATGTGCTGTGGAGGAAGAAGTGGCATGCAAAGGGCTTTGGAATG ACTTTGAAGGGCCCTAATGACTTCAAGCTGGAGGACTTCTACTCTGCTTCCAGTGAACTC TTCGAACCCTACTATGGTGAGGGTGGGATTGATGGAGATGGAGATATCACCCGCCCAGAG AACATCTCTGCTTTTCGGAATTTTGTCCTGGATAACACAGATCGCAAGGGTGTCCATTTT CTGATGGCTGATGGGGGTTTCTCGGTGGAGGGGCAGGAGAACCTGCAGGAGATCCTCAGC AAGCAGCTGCTTCTGTGTCAGTTCCTCATGGCGCTGTCCATTGTCCGGACAGGAGGCCAC TTCATCTGTAAAACCTTTGACCTGTTCACACCGTTTAGTGTGGGGCTTGTCTACCTGCTG TACTGCTGCTTTGAACGAGTTTGTCTCTTCAAGCCTATTACCAGCCGTCCTGCCAACTCA GAGAGGTATGTGGTGTGCAAGGGCCTGAAGGTGGGCATAGATGATGTTCGGGATTACCTC TTCGCAGTGAATATTAAACTCAATCAGCTGCGGAACACGGATTCCGACGTCAACTTGGTG GTCCCCCTGGAGGTGATCAAGGGAGACCATGAATTTACTGACTACATGATACGGTCCAAT GAGAGCCACTGTAGTCTGCAGATCAAAGCTCTGGCGAAAATCCATGCCTTTGTTCAAGAC ACGACACTGAGTGAGCCTCGACAGGCAGAGATACGGAAGGAGTGCCTCCGACTCTGGGGG ATCCCAGACCAGGCTCGTGTGGCTCCTTCTTCCTCCGACCCTAAATCGAAGTTCTTTGAG CTAATCCAGGGCACTGAGATTGACATCTTCAGCTACAAGCCCACACTGCTCACCTCTAAA ACCCTGGAGAAGATCCGCCCTGTGTTTGACTACCGCTGCATGGTATCTGGCAGTGAGCAG AAGTTCCTCATCGGCCTGGGGAAATCCCAGATCTACACATGGGATGGCCGCCAGTCAGAC CGCTGGATCAAGCTAGACCTGAAGACAGAGCTGCCCCGGGACACTCTGCTATCTGTGGAA ATTGTGCATGAGCTGAAAGGGGAGGGGAAGGCCCAGAGGAAGATCAGTGCCATCCACATC CTCGATGTCCTTGTGCTGAATGGCACCGACGTTCGGGAGCAGCACTTTAACCAGCGAATT CAGCTTGCCGAGAAATTTGTGAAAGCCGTTTCCAAGCCTAGTCGGCCCGACATGAATCCC ATCAGGGTGAAGGAGGTGTACAGACTGGAAGAGATGGAGAAGATTTTTGTCAGGTTGGAG ATGAAGATCATCAAGGGCTCCAGTGGCACCCCAAAGCTCAGCTACACAGGGCGTGATGAC CGGCACTTTGTACCCATGGGCCTCTACATCGTCAGGACAGTGAATGAGCCCTGGACTATG GGATTCAGCAAAAGCTTCAAGAAGAAGTTCTTCTACAACAAGAAAACCAAGGACTCTACT TTTGACCTCCCTGCAGACTCCATTGCCCCATTTCACATTTGCTACTATGGCCGGCTCTTC TGGGAGTGGGGGGATGGCATTCGTGTGCATGACTCCCAGAAGCCCCAGGACCAGGACAAG CTGTCCAAGGAGGACGTCCTCTCCTTCATCCAGATGCACAGGGCCTAA
- Chromosome Location
- 6
- Locus
- 6p21.2
- External Identifiers
Resource Link UniProtKB ID Q8N1G2 UniProtKB Entry Name CMTR1_HUMAN HGNC ID HGNC:21077 - General References
- Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al.: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 1995;2(1):37-43. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Geiss GK, Carter VS, He Y, Kwieciszewski BK, Holzman T, Korth MJ, Lazaro CA, Fausto N, Bumgarner RE, Katze MG: Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein. J Virol. 2003 Jun;77(11):6367-75. [Article]
- Guerra S, Lopez-Fernandez LA, Pascual-Montano A, Munoz M, Harshman K, Esteban M: Cellular gene expression survey of vaccinia virus infection of human HeLa cells. J Virol. 2003 Jun;77(11):6493-506. [Article]
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [Article]
- Haline-Vaz T, Silva TC, Zanchin NI: The human interferon-regulated ISG95 protein interacts with RNA polymerase II and shows methyltransferase activity. Biochem Biophys Res Commun. 2008 Aug 8;372(4):719-24. doi: 10.1016/j.bbrc.2008.05.137. Epub 2008 Jun 3. [Article]
- Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
- Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [Article]
- Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M: Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science. 2009 Aug 14;325(5942):834-40. doi: 10.1126/science.1175371. Epub 2009 Jul 16. [Article]
- Belanger F, Stepinski J, Darzynkiewicz E, Pelletier J: Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase. J Biol Chem. 2010 Oct 22;285(43):33037-44. doi: 10.1074/jbc.M110.155283. Epub 2010 Aug 16. [Article]
- Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. [Article]
- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
- Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM: 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. Nucleic Acids Res. 2011 Jun;39(11):4756-68. doi: 10.1093/nar/gkr038. Epub 2011 Feb 9. [Article]
- Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Smietanski M, Werner M, Purta E, Kaminska KH, Stepinski J, Darzynkiewicz E, Nowotny M, Bujnicki JM: Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation. Nat Commun. 2014;5:3004. doi: 10.1038/ncomms4004. [Article]