Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

Details

Name
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Synonyms
  • 2.1.1.57
  • Cap methyltransferase 1
  • Cap1 2'O-ribose methyltransferase 1
  • FtsJ methyltransferase domain-containing protein 2
  • FTSJD2
  • hMTr1
  • Interferon-stimulated gene 95 kDa protein
  • ISG95
  • KIAA0082
  • MTR1
Gene Name
CMTR1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049708|Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
MKRRTDPECTAPIKKQKKRVAELALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGK
QHSSDSFDDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFREGEGLGKYSQGRKDIVEAS
SQKGRRGLGLTLRGFDQELNVDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKR
KMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKM
ANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGM
TLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENISAFRNFVLDNTDRKGVHF
LMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLL
YCCFERVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLV
VPLEVIKGDHEFTDYMIRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWG
IPDQARVAPSSSDPKSKFFELIQGTEIDIFSYKPTLLTSKTLEKIRPVFDYRCMVSGSEQ
KFLIGLGKSQIYTWDGRQSDRWIKLDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHI
LDVLVLNGTDVREQHFNQRIQLAEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLE
MKIIKGSSGTPKLSYTGRDDRHFVPMGLYIVRTVNEPWTMGFSKSFKKKFFYNKKTKDST
FDLPADSIAPFHICYYGRLFWEWGDGIRVHDSQKPQDQDKLSKEDVLSFIQMHRA
Number of residues
835
Molecular Weight
95319.96
Theoretical pI
Not Available
GO Classification
Functions
mRNA (nucleoside-2'-O-)-methyltransferase activity / nucleic acid binding
Processes
7-methylguanosine mRNA capping / cap1 mRNA methylation / mRNA methylation
Components
cytosol / nucleoplasm / nucleus
General Function
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.
Specific Function
Mrna (nucleoside-2'-o-)-methyltransferase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0049709|Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (CMTR1)
ATGAAGAGGAGAACTGACCCAGAATGCACTGCCCCCATCAAGAAACAGAAAAAAAGAGTT
GCAGAGCTTGCCCTGAGCCTCAGCTCCACGTCCGATGATGAACCTCCCTCCTCTGTCAGT
CATGGAGCAAAAGCATCTACTACAAGCCTTAGTGGGTCTGATAGTGAGACCGAGGGGAAA
CAACACAGCTCTGACTCTTTTGACGATGCATTCAAAGCAGACTCTCTTGTGGAAGGAACT
TCTTCTCGCTATTCCATGTATAATAGCGTCTCCCAGAAGCTTATGGCCAAGATGGGCTTC
AGGGAAGGTGAAGGATTGGGTAAATACAGCCAGGGTCGGAAGGACATCGTTGAGGCTTCC
AGTCAGAAAGGTCGAAGAGGCTTGGGTCTGACACTCCGGGGCTTTGACCAGGAGCTGAAC
GTGGACTGGCGAGATGAGCCAGAGCCCAGTGCTTGTGAGCAGGTGTCATGGTTTCCAGAA
TGTACCACTGAAATTCCTGACACTCAGGAAATGAGCGATTGGATGGTGGTGGGAAAGAGA
AAGATGATTATTGAAGATGAAACAGAGTTTTGTGGGGAAGAGCTGCTTCACAGTGTGTTG
CAGTGTAAGAGCGTGTTTGATGTCTTGGATGGGGAAGAGATGCGGCGAGCTCGGACTCGG
GCCAATCCCTATGAGATGATCCGAGGAGTCTTCTTTCTAAACAGGGCAGCAATGAAGATG
GCTAACATGGATTTTGTATTTGATCGCATGTTCACAAATCCGCGGGACTCTTATGGGAAG
CCACTGGTGAAGGACCGGGAAGCTGAGCTTCTGTACTTTGCTGATGTCTGCGCAGGCCCA
GGTGGCTTCTCAGAGTATGTGCTGTGGAGGAAGAAGTGGCATGCAAAGGGCTTTGGAATG
ACTTTGAAGGGCCCTAATGACTTCAAGCTGGAGGACTTCTACTCTGCTTCCAGTGAACTC
TTCGAACCCTACTATGGTGAGGGTGGGATTGATGGAGATGGAGATATCACCCGCCCAGAG
AACATCTCTGCTTTTCGGAATTTTGTCCTGGATAACACAGATCGCAAGGGTGTCCATTTT
CTGATGGCTGATGGGGGTTTCTCGGTGGAGGGGCAGGAGAACCTGCAGGAGATCCTCAGC
AAGCAGCTGCTTCTGTGTCAGTTCCTCATGGCGCTGTCCATTGTCCGGACAGGAGGCCAC
TTCATCTGTAAAACCTTTGACCTGTTCACACCGTTTAGTGTGGGGCTTGTCTACCTGCTG
TACTGCTGCTTTGAACGAGTTTGTCTCTTCAAGCCTATTACCAGCCGTCCTGCCAACTCA
GAGAGGTATGTGGTGTGCAAGGGCCTGAAGGTGGGCATAGATGATGTTCGGGATTACCTC
TTCGCAGTGAATATTAAACTCAATCAGCTGCGGAACACGGATTCCGACGTCAACTTGGTG
GTCCCCCTGGAGGTGATCAAGGGAGACCATGAATTTACTGACTACATGATACGGTCCAAT
GAGAGCCACTGTAGTCTGCAGATCAAAGCTCTGGCGAAAATCCATGCCTTTGTTCAAGAC
ACGACACTGAGTGAGCCTCGACAGGCAGAGATACGGAAGGAGTGCCTCCGACTCTGGGGG
ATCCCAGACCAGGCTCGTGTGGCTCCTTCTTCCTCCGACCCTAAATCGAAGTTCTTTGAG
CTAATCCAGGGCACTGAGATTGACATCTTCAGCTACAAGCCCACACTGCTCACCTCTAAA
ACCCTGGAGAAGATCCGCCCTGTGTTTGACTACCGCTGCATGGTATCTGGCAGTGAGCAG
AAGTTCCTCATCGGCCTGGGGAAATCCCAGATCTACACATGGGATGGCCGCCAGTCAGAC
CGCTGGATCAAGCTAGACCTGAAGACAGAGCTGCCCCGGGACACTCTGCTATCTGTGGAA
ATTGTGCATGAGCTGAAAGGGGAGGGGAAGGCCCAGAGGAAGATCAGTGCCATCCACATC
CTCGATGTCCTTGTGCTGAATGGCACCGACGTTCGGGAGCAGCACTTTAACCAGCGAATT
CAGCTTGCCGAGAAATTTGTGAAAGCCGTTTCCAAGCCTAGTCGGCCCGACATGAATCCC
ATCAGGGTGAAGGAGGTGTACAGACTGGAAGAGATGGAGAAGATTTTTGTCAGGTTGGAG
ATGAAGATCATCAAGGGCTCCAGTGGCACCCCAAAGCTCAGCTACACAGGGCGTGATGAC
CGGCACTTTGTACCCATGGGCCTCTACATCGTCAGGACAGTGAATGAGCCCTGGACTATG
GGATTCAGCAAAAGCTTCAAGAAGAAGTTCTTCTACAACAAGAAAACCAAGGACTCTACT
TTTGACCTCCCTGCAGACTCCATTGCCCCATTTCACATTTGCTACTATGGCCGGCTCTTC
TGGGAGTGGGGGGATGGCATTCGTGTGCATGACTCCCAGAAGCCCCAGGACCAGGACAAG
CTGTCCAAGGAGGACGTCCTCTCCTTCATCCAGATGCACAGGGCCTAA
Chromosome Location
6
Locus
6p21.2
External Identifiers
ResourceLink
UniProtKB IDQ8N1G2
UniProtKB Entry NameCMTR1_HUMAN
HGNC IDHGNC:21077
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00118Ademetionineapproved, investigational, nutraceuticalunknownDetails