Carboxypeptidase A6
Details
- Name
- Carboxypeptidase A6
- Synonyms
- 3.4.17.-
- CPAH
- Gene Name
- CPA6
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052489|Carboxypeptidase A6 MKCLGKRRGQAAAFLPLCWLFLKILQPGHSHLYNNRYAGDKVIRFIPKTEEEAYALKKIS YQLKVDLWQPSSISYVSEGTVTDVHIPQNGSRALLAFLQEANIQYKVLIEDLQKTLEKGS SLHTQRNRRSLSGYNYEVYHSLEEIQNWMHHLNKTHSGLIHMFSIGRSYEGRSLFILKLG RRSRLKRAVWIDCGIHAREWIGPAFCQWFVKEALLTYKSDPAMRKMLNHLYFYIMPVFNV DGYHFSWTNDRFWRKTRSRNSRFRCRGVDANRNWKVKWCDEGASMHPCDDTYCGPFPESE PEVKAVANFLRKHRKHIRAYLSFHAYAQMLLYPYSYKYATIPNFRCVESAAYKAVNALQS VYGVRYRYGPASTTLYVSSGSSMDWAYKNGIPYAFAFELRDTGYFGFLLPEMLIKPTCTE TMLAVKNITMHLLKKCP
- Number of residues
- 437
- Molecular Weight
- 51007.48
- Theoretical pI
- Not Available
- GO Classification
- Functionsmetallocarboxypeptidase activity / zinc ion bindingProcessesproteolysisComponentsextracellular space
- General Function
- May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II (PubMed:18178555). Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine (PubMed:20855895).
- Specific Function
- Metallocarboxypeptidase activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0052490|Carboxypeptidase A6 (CPA6) ATGAAGTGTCTCGGGAAGCGCAGGGGCCAGGCAGCTGCTTTCCTGCCTCTTTGCTGGCTC TTTTTGAAGATTCTGCAACCGGGGCACAGCCACCTTTATAACAACCGCTATGCTGGTGAT AAAGTGATAAGATTTATTCCCAAAACAGAAGAGGAAGCATATGCACTGAAGAAAATATCC TATCAACTTAAGGTGGACCTGTGGCAGCCCAGCAGTATCTCCTATGTATCAGAGGGAACA GTTACTGATGTCCATATCCCCCAAAATGGTTCCCGAGCCCTGTTAGCCTTCTTACAGGAA GCCAACATCCAGTACAAGGTCCTCATAGAAGATCTTCAGAAAACACTGGAGAAGGGAAGC AGCTTGCACACCCAGAGAAACCGAAGATCCCTCTCTGGATATAATTATGAAGTTTATCAC TCCTTAGAAGAAATTCAAAATTGGATGCATCATCTGAATAAAACTCACTCAGGCCTCATT CACATGTTCTCTATTGGAAGATCATATGAGGGAAGATCTCTTTTTATTTTAAAGCTGGGC AGACGATCACGACTCAAAAGAGCTGTTTGGATAGACTGTGGTATTCATGCAAGAGAATGG ATTGGTCCTGCCTTTTGTCAGTGGTTTGTAAAAGAAGCTCTTCTAACATATAAGAGTGAC CCAGCCATGAGAAAAATGTTGAATCATCTATATTTCTATATCATGCCTGTGTTTAACGTC GATGGATACCATTTTAGTTGGACCAATGATCGATTTTGGAGAAAAACAAGGTCAAGGAAC TCAAGGTTTCGCTGCCGTGGAGTGGATGCCAATAGAAACTGGAAAGTGAAGTGGTGTGAT GAAGGAGCTTCTATGCACCCTTGTGATGACACATACTGTGGCCCTTTTCCAGAATCTGAG CCGGAAGTGAAGGCTGTAGCTAACTTCCTTCGAAAACACAGAAAGCACATTAGGGCTTAT CTCTCCTTTCATGCATATGCTCAGATGTTACTGTATCCCTATTCTTACAAATATGCAACA ATTCCCAATTTTAGATGTGTGGAATCTGCAGCTTATAAAGCTGTGAATGCACTTCAGTCA GTATACGGGGTACGATACAGATATGGACCAGCCTCCACAACGTTGTATGTGAGCTCTGGT AGCTCAATGGATTGGGCCTACAAAAATGGAATACCTTATGCATTTGCTTTCGAACTACGT GACACTGGATATTTTGGATTTTTACTCCCAGAGATGCTCATCAAACCCACCTGTACAGAA ACTATGCTGGCTGTGAAAAATATCACAATGCACCTGCTAAAGAAATGTCCCTGA
- Chromosome Location
- 8
- Locus
- 8q13.2
- External Identifiers
Resource Link UniProtKB ID Q8N4T0 UniProtKB Entry Name CBPA6_HUMAN HGNC ID HGNC:17245 - General References
- Wei S, Segura S, Vendrell J, Aviles FX, Lanoue E, Day R, Feng Y, Fricker LD: Identification and characterization of three members of the human metallocarboxypeptidase gene family. J Biol Chem. 2002 Apr 26;277(17):14954-64. doi: 10.1074/jbc.M112254200. Epub 2002 Feb 8. [Article]
- Pizzuti A, Calabrese G, Bozzali M, Telvi L, Morizio E, Guida V, Gatta V, Stuppia L, Ion A, Palka G, Dallapiccola B: A peptidase gene in chromosome 8q is disrupted by a balanced translocation in a duane syndrome patient. Invest Ophthalmol Vis Sci. 2002 Dec;43(12):3609-12. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Lyons PJ, Callaway MB, Fricker LD: Characterization of carboxypeptidase A6, an extracellular matrix peptidase. J Biol Chem. 2008 Mar 14;283(11):7054-63. doi: 10.1074/jbc.M707680200. Epub 2008 Jan 4. [Article]
- Lyons PJ, Fricker LD: Substrate specificity of human carboxypeptidase A6. J Biol Chem. 2010 Dec 3;285(49):38234-42. doi: 10.1074/jbc.M110.158626. Epub 2010 Sep 20. [Article]
- Salzmann A, Guipponi M, Lyons PJ, Fricker LD, Sapio M, Lambercy C, Buresi C, Ouled Amar Bencheikh B, Lahjouji F, Ouazzani R, Crespel A, Chaigne D, Malafosse A: Carboxypeptidase A6 gene (CPA6) mutations in a recessive familial form of febrile seizures and temporal lobe epilepsy and in sporadic temporal lobe epilepsy. Hum Mutat. 2012 Jan;33(1):124-35. doi: 10.1002/humu.21613. Epub 2011 Oct 31. [Article]