3-oxoacyl-[acyl-carrier-protein] reductase

Details

Name
3-oxoacyl-[acyl-carrier-protein] reductase
Synonyms
  • 1.1.1.100
  • 3-ketoacyl-[acyl-carrier-protein] reductase beta subunit
  • Carbonyl reductase family member 4
  • CBR4
  • KAR beta subunit
  • Quinone reductase CBR4
  • SDR45C1
  • Short chain dehydrogenase/reductase family 45C member 1
Gene Name
CBR4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052673|3-oxoacyl-[acyl-carrier-protein] reductase
MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKE
HDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMR
TMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGF
VHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL
Number of residues
237
Molecular Weight
25301.24
Theoretical pI
Not Available
GO Classification
Functions
3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity / NAD(P)H dehydrogenase (quinone) activity / NADPH binding / NADPH dehydrogenase (quinone) activity / oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor / quinone binding
Processes
daunorubicin metabolic process / doxorubicin metabolic process / fatty acid biosynthetic process / fatty-acyl-CoA biosynthetic process / protein heterotetramerization / protein homotetramerization
Components
mitochondrial matrix / oxidoreductase complex
General Function
Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis (PubMed:25203508). The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19000905). As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508).
Specific Function
3-oxoacyl-[acyl-carrier-protein] reductase (nadh) activity
Pfam Domain Function
Not Available
Transmembrane Regions
Not Available
Cellular Location
Mitochondrion matrix
Gene sequence
>lcl|BSEQ0052674|3-oxoacyl-[acyl-carrier-protein] reductase (CBR4)
ATGGACAAAGTGTGTGCTGTTTTTGGAGGCTCCCGAGGCATTGGCAGAGCTGTGGCCCAG
TTAATGGCCCGGAAAGGCTACCGACTGGCGGTCATTGCCAGAAACCTGGAAGGGGCCAAA
GCCGCCGCCGGTGACCTCGGCGGAGATCATTTGGCATTTAGCTGTGATGTTGCTAAAGAA
CATGATGTTCAAAATACATTTGAAGAGCTGGAGAAACATTTAGGTCGAGTAAATTTCTTG
GTAAATGCAGCTGGTATTAACAGGGATGGTCTTTTAGTAAGAACAAAAACTGAAGATATG
GTATCTCAGCTTCATACTAACCTCTTGGGTTCCATGCTGACCTGTAAAGCTGCCATGAGG
ACTATGATTCAACAACAGGGAGGGTCTATTGTTAATGTAGGAAGCATTGTTGGCTTAAAA
GGCAACTCTGGCCAGTCCGTTTACAGTGCCAGTAAAGGAGGATTAGTTGGATTTTCACGT
GCTCTTGCTAAAGAGGTAGCAAGAAAGAAAATTAGAGTGAATGTAGTTGCACCAGGATTT
GTACACACAGATATGACGAAAGACTTGAAAGAAGAACATTTAAAGAAAAATATTCCTCTT
GGGAGGTTTGGAGAAACTATTGAGGTGGCACATGCGGTTGTGTTTCTTTTAGAATCACCG
TATATTACAGGGCATGTTCTGGTAGTGGATGGGGGATTACAACTCATTTTGTAA
Chromosome Location
4
Locus
4q32.3
External Identifiers
ResourceLink
UniProtKB IDQ8N4T8
UniProtKB Entry NameCBR4_HUMAN
HGNC IDHGNC:25891
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails