Thiosulfate:glutathione sulfurtransferase

Details

Name

Thiosulfate:glutathione sulfurtransferase

Synonyms

• 2.8.1.-
• KAT
• TST

Gene Name

TSTD1

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052795|Thiosulfate:glutathione sulfurtransferase
MAGAPTVSLPELRSLLASGRARLFDVRSREEAAAGTIPGALNIPVSELESALQMEPAAFQ
ALYSAEKPKLEDEHLVFFCQMGKRGLQATQLARSLGYTGARNYAGAYREWLEKES

Number of residues

115

Molecular Weight

12530.1

Theoretical pI

Not Available

GO Classification

Functions

DNA-binding transcription factor activity, RNA polymerase II-specific / double-stranded DNA binding / identical protein binding / protein-containing complex binding / sequence-specific DNA binding / thiosulfate-thiol sulfurtransferase activity

Processes

glucose metabolic process / positive regulation of transcription by RNA polymerase II / sulfide oxidation, using sulfide

Components

cytoplasm / cytoplasmic ribonucleoprotein granule / cytosol / nucleus / perinuclear region of cytoplasm

General Function

Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolism (PubMed:24981631). Provides the link between the first step in mammalian H(2)S metabolism performed by the sulfide:quinone oxidoreductase (SQOR) which catalyzes the conversion of H(2)S to thiosulfate, and the sulfur dioxygenase (SDO) which uses GSS(-) as substrate (PubMed:24981631). The thermodynamic coupling of the irreversible SDO and reversible TST reactions provides a model for the physiologically relevant reaction with thiosulfate as the sulfane donor (PubMed:24981631).

Specific Function

Dna-binding transcription factor activity, rna polymerase ii-specific

Pfam Domain Function

• Rhodanese (PF00581)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0052796|Thiosulfate:glutathione sulfurtransferase (TSTD1)
ATGGCTGGAGCGCCCACGGTCTCGCTTCCTGAACTCCGTTCACTCCTAGCCTCCGGACGG
GCCCGGCTCTTCGACGTGCGCTCTCGCGAGGAGGCGGCAGCTGGGACCATCCCAGGGGCG
CTCAACATCCCGGTGTCCGAGTTGGAGAGTGCTCTGCAGATGGAGCCAGCTGCCTTCCAG
GCTTTATATTCTGCTGAGAAGCCAAAGCTGGAAGATGAGCATCTCGTTTTCTTCTGTCAG
ATGGGCAAGCGGGGCCTCCAGGCCACGCAGCTGGCCCGGAGTCTTGGATACACTGGGGCT
CGCAACTACGCTGGAGCCTATAGAGAATGGTTGGAGAAAGAGAGTTAG

Chromosome Location

1

Locus

1q23.3

External Identifiers

Resource	Link
UniProtKB ID	Q8NFU3
UniProtKB Entry Name	TSTD1_HUMAN
HGNC ID	HGNC:35410

General References

Not Available

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB09499	Thiosulfuric acid	approved, investigational	unknown	substrate	Details