Peptide deformylase
Details
- Name
- Peptide deformylase
- Synonyms
- 3.5.1.88
- def1
- pdf1
- Polypeptide deformylase
- Gene Name
- def
- Organism
- Staphylococcus aureus (strain MW2)
- Amino acid sequence
>lcl|BSEQ0016511|Peptide deformylase MLTMKDIIRDGHPTLRQKAAELELPLTKEEKETLIAMREFLVNSQDEEIAKRYGLRSGVG LAAPQINISKRMIAVLIPDDGSGKSYDYMLVNPKIVSHSVQEAYLPTGEGCLSVDDNVAG LVHRHNRITIKAKDIEGNDIQLRLKGYPAIVFQHEIDHLNGVMFYDHIDKDHPLQPHTDA VEV
- Number of residues
- 183
- Molecular Weight
- 20559.37
- Theoretical pI
- 6.03
- GO Classification
- Functionsiron ion binding / peptide deformylase activityProcessestranslation
- General Function
- Peptide deformylase activity
- Specific Function
- Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
- Pfam Domain Function
- Pep_deformylase (PF01327)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0003274|552 bp TTAAACTTCTACAGCATCTGTATGTGGTTGTAATGGGTGATCTTTGTCAATGTGATCATA GAACATTACACCATTTAAATGGTCAATTTCATGTTGGAAAACAATTGCTGGATATCCTTT TAGACGTAATTGTATATCATTACCTTCGATGTCTTTGGCTTTAATTGTAATTCTATTATG ACGGTGAACTAGACCAGCAACATTATCATCGACACTAAGGCAACCTTCACCAGTTGGTAA ATAAGCTTCTTGAACGCTATGACTTACAATTTTTGGGTTCACAAGCATATAGTCATAAGA TTTGCCACTGCCATCATCTGGTATTAAAACAGCAATCATACGTTTAGAAATATTAATTTG AGGTGCAGCCAAACCAACGCCTGAACGTAAACCATATCGTTTCGCGATTTCCTCATCTTG ACTATTTACTAAAAACTCTCTCATGGCGATTAATGTTTCTTTTTCTTCTTTAGTTAATGG TAATTCTAACTCAGCTGCTTTTTGACGCAAAGTTGGATGACCATCTCTAATGATGTCTTT CATTGTTAACAT
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8NX78 UniProtKB Entry Name DEF_STAAW GenBank Protein ID 21204141 GenBank Gene ID BA000033 - General References
- Baba T, Takeuchi F, Kuroda M, Yuzawa H, Aoki K, Oguchi A, Nagai Y, Iwama N, Asano K, Naimi T, Kuroda H, Cui L, Yamamoto K, Hiramatsu K: Genome and virulence determinants of high virulence community-acquired MRSA. Lancet. 2002 May 25;359(9320):1819-27. [Article]