Pol protein
Details
- Name
- Pol protein
- Synonyms
- Not Available
- Gene Name
- pol
- Organism
- Human immunodeficiency virus 1
- Amino acid sequence
>lcl|BSEQ0012335|Pol protein PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
- Number of residues
- 99
- Molecular Weight
- 10792.72
- Theoretical pI
- 8.77
- GO Classification
- Functionsaspartic-type endopeptidase activity
- General Function
- Aspartic-type endopeptidase activity
- Specific Function
- Not Available
- Pfam Domain Function
- RVP (PF00077)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0006514|297 bp CCTCAAATCACTCTTTGGCAACGACCCCTCGTCACAATAAAGATAGGGGGGCAACTAAAG GAAGCTCTATTAGATACAGGAGCAGATGATACAGTATTAGAAGAAATGAGTTTACCAGGG AGATGGAAACCAAAAATGATAGGGGGAATTGGAGGTTTTATCAAAGTAAGACAGTATGAT CAGATACTCATAGAAATCTGTGGACATAAAGCTATAGGTACAGTATTAGTAGGACCTACA CCTGTCAACATAATTGGAAGAAATCTGTTGACTCAGATTGGCTGCACTTTAAATTTT
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8Q3H0 UniProtKB Entry Name Q8Q3H0_9HIV1 GenBank Gene ID AF481428 - General References
- Sung H, Foley BT, Ahn SH, Kim YB, Chae JD, Shin YO, Kang HI, Cho YK: Natural polymorphisms of protease in protease inhibitor-naive HIV-1 infected patients in Korea: a novel L63M in subtype B. AIDS Res Hum Retroviruses. 2003 Jun;19(6):525-30. [Article]
- Ekegren JK, Ginman N, Johansson A, Wallberg H, Larhed M, Samuelsson B, Unge T, Hallberg A: Microwave-accelerated synthesis of P1'-extended HIV-1 protease inhibitors encompassing a tertiary alcohol in the transition-state mimicking scaffold. J Med Chem. 2006 Mar 9;49(5):1828-32. [Article]
- Sung H, Jung YS, Kang MW, Bae IG, Chang HH, Woo JH, Cho YK: High frequency of drug resistance mutations in human immunodeficiency virus type 1-infected Korean patients treated with HAART. AIDS Res Hum Retroviruses. 2007 Oct;23(10):1223-9. [Article]
- Wu X, Ohrngren P, Joshi AA, Trejos A, Persson M, Arvela RK, Wallberg H, Vrang L, Rosenquist A, Samuelsson BB, Unge J, Larhed M: Synthesis, X-ray analysis, and biological evaluation of a new class of stereopure lactam-based HIV-1 protease inhibitors. J Med Chem. 2012 Mar 22;55(6):2724-36. doi: 10.1021/jm201620t. Epub 2012 Mar 13. [Article]
- Ghosh AK, Martyr CD, Kassekert LA, Nyalapatla PR, Steffey M, Agniswamy J, Wang YF, Weber IT, Amano M, Mitsuya H: Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands. Org Biomol Chem. 2015 Dec 28;13(48):11607-21. doi: 10.1039/c5ob01930c. Epub 2015 Oct 14. [Article]