2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Details

Name
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Synonyms
  • 4.6.1.12
  • MECDP-synthase
Gene Name
ispF
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Amino acid sequence
>lcl|BSEQ0016497|2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
MRIGYGEDSHRLEEGRPLYLCGLLIPSPVGALAHSDGDAALHALTDALLSAYGLGDIGLL
FPDTDPRWRGERSEVFLREALRLVEARGAKLLQASLVLTLDRPKLGPHRKALVDSLSRLL
RLPQDRIGLTFKTSEGLAPSHVQARAVVLLDG
Number of residues
152
Molecular Weight
16519.835
Theoretical pI
7.73
GO Classification
Functions
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity / metal ion binding
Processes
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway / terpenoid biosynthetic process
General Function
Metal ion binding
Specific Function
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0016498|2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF)
ATGCGCATCGGCTACGGCGAGGACAGCCACCGCCTGGAGGAGGGGAGGCCGCTTTACCTC
TGCGGCCTCCTCATTCCAAGCCCCGTGGGGGCCCTGGCCCACTCCGATGGGGACGCCGCC
CTCCACGCCCTCACCGACGCCCTCCTTTCCGCCTACGGCCTTGGGGACATCGGCCTCCTC
TTCCCCGACACCGATCCCCGCTGGCGGGGCGAGCGGAGCGAGGTGTTTCTCCGGGAGGCC
CTCCGCCTCGTGGAAGCGCGGGGGGCGAAGCTGCTTCAGGCGAGCCTCGTCCTCACCCTG
GACCGGCCCAAGCTCGGCCCCCACCGCAAGGCCTTGGTGGACAGCCTATCCCGCCTCCTC
CGCCTTCCCCAGGACCGCATTGGCCTCACCTTCAAGACCTCGGAGGGCCTGGCGCCTTCC
CACGTCCAGGCCCGGGCGGTGGTGCTTCTGGATGGTTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ8RQP5
UniProtKB Entry NameISPF_THET8
GenBank Protein ID19911566
GenBank Gene IDAB082126
General References
  1. Kishida H, Wada T, Unzai S, Kuzuyama T, Takagi M, Terada T, Shirouzu M, Yokoyama S, Tame JR, Park SY: Structure and catalytic mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MECDP) synthase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):23-31. Epub 2002 Dec 19. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03403Cytidine-5'-MonophosphateexperimentalunknownDetails
DB04555Cytidine-5'-DiphosphateexperimentalunknownDetails