UDP-galactose 4-epimerase

Details

Name
UDP-galactose 4-epimerase
Synonyms
  • EC 5.1.3.2
Gene Name
galE
Organism
Trypanosoma brucei
Amino acid sequence
>lcl|BSEQ0022431|UDP-galactose 4-epimerase
MRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGP
KPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNNVV
GILRLLQAMLLHKCDKIIFSSSAAIFGNPTMGSVSTNAEPIDINAKKSPESPYGESKLIA
ERMIRDCAEAYGIKGICLRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIAPDQRL
TIHEDASTDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDKSKYFS
VFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWKPKYD
TLEAIMETSWKFQRTHPNGYASQENGTPGGRTTKL
Number of residues
395
Molecular Weight
43519.96
Theoretical pI
6.91
GO Classification
Functions
coenzyme binding / nucleotide binding / UDP-glucose 4-epimerase activity
Processes
galactose metabolic process
General Function
Udp-glucose 4-epimerase activity
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0005132|1188 bp
ATGCGCGTTTTGGTTTGTGGAGGCGCAGGTTACATTGGAAGCCACTTCGTGCGGGCTCTT
TTGCGCGACACGAACCACAGTGTTGTCATCGTTGACTCGCTTGTGGGGACGCATGGGAAA
AGCGACCATGTGGAAACCAGGGAAAATGTAGCGCGAAAGTTGCAACAAAGTGATGGACCG
AAGCCGCCGTGGGCGGATCGATACGCCGCACTGGAGGTGGGAGACGTGCGTAACGAAGAC
TTCCTTAACGGCGTTTTCACTCGCCATGGTCCTATCGATGCTGTTGTCCACATGTGTGCT
TTCCTTGCCGTTGGTGAGAGTGTGAGAGATCCACTAAAGTATTATGACAACAATGTGGTT
GGTATTCTAAGGTTGCTTCAAGCGATGTTGTTACACAAGTGCGACAAAATCATCTTCTCC
AGTAGTGCCGCCATTTTTGGCAACCCAACAATGGGCTCCGTGTCCACAAACGCAGAACCC
ATCGATATTAACGCCAAAAAGAGCCCAGAAAGTCCATATGGCGAGTCAAAACTTATTGCG
GAGAGGATGATAAGGGATTGCGCGGAAGCATACGGGATTAAAGGCATTTGCCTCCGTTAC
TTCAATGCCTGTGGAGCGCACGAGGATGGAGATATCGGTGAGCATTACCAAGGCTCCACG
CATCTAATCCCTATAATCTTGGGTAGGGTAATGAGCGACATCGCACCGGATCAAAGATTA
ACAATTCACGAGGATGCGTCAACTGACAAGAGAATGCCCATATTTGGTACAGACTATCCT
ACACCCGACGGCACGTGTGTACGGGACTATGTTCACGTGTGTGATCTTGCGTCGGCTCAC
ATATTAGCTCTTGATTACGTGGAGAAACTGGGACCGAATGACAAGTCCAAGTACTTCTCT
GTGTTTAACCTTGGCACTTCGCGGGGGTACTCCGTGCGTGAGGTTATAGAAGTGGCGCGC
AAGACTACTGGGCACCCGATTCCGGTGCGTGAGTGTGGCCGTCGGGAGGGGGACCCGGCG
TATCTTGTGGCTGCCAGCGATAAGGCACGGGAGGTGCTGGGCTGGAAACCAAAATACGAC
ACTCTCGAGGCCATCATGGAAACATCCTGGAAGTTTCAGCGCACTCACCCTAATGGGTAC
GCATCACAGGAAAATGGAACGCCGGGGGGAAGGACCACTAAGTTGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ8T8E9
UniProtKB Entry NameQ8T8E9_9TRYP
GenBank Gene IDAJ430490
General References
  1. Shaw MP, Bond CS, Roper JR, Gourley DG, Ferguson MA, Hunter WN: High-resolution crystal structure of Trypanosoma brucei UDP-galactose 4'-epimerase: a potential target for structure-based development of novel trypanocides. Mol Biochem Parasitol. 2003 Feb;126(2):173-80. [Article]
  2. Alphey MS, Burton A, Urbaniak MD, Boons GJ, Ferguson MA, Hunter WN: Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Sep 1;62(Pt 9):829-34. Epub 2006 Aug 11. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03435Uridine-5'-DiphosphateexperimentalunknownDetails