Potassium voltage-gated channel subfamily G member 3

Details

Name
Potassium voltage-gated channel subfamily G member 3
Synonyms
  • Voltage-gated potassium channel subunit Kv10.1
  • Voltage-gated potassium channel subunit Kv6.3
Gene Name
KCNG3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052237|Potassium voltage-gated channel subfamily G member 3
MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNE
YFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRM
SDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVF
VIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRF
IVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVI
KLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSI
PAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELK
FRSARYSRSLSTEFLN
Number of residues
436
Molecular Weight
49592.025
Theoretical pI
Not Available
GO Classification
Functions
delayed rectifier potassium channel activity / voltage-gated potassium channel activity
Processes
potassium ion transmembrane transport / protein homooligomerization / regulation of ion transmembrane transport
Components
endoplasmic reticulum / integral component of membrane / plasma membrane / voltage-gated potassium channel complex
General Function
Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135).
Specific Function
Delayed rectifier potassium channel activity
Pfam Domain Function
Transmembrane Regions
169-190 221-242 254-274 285-305 321-342 388-416
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052238|Potassium voltage-gated channel subfamily G member 3 (KCNG3)
ATGACCTTCGGGCGCAGCGGGGCGGCCTCGGTGGTGCTGAACGTGGGCGGCGCCCGGTAT
TCGCTGTCCCGGGAGCTGCTGAAGGACTTCCCGCTGCGCCGCGTGAGCCGGCTGCACGGC
TGCCGCTCCGAGCGCGACGTGCTCGAGGTGTGCGACGACTACGACCGCGAGCGCAACGAG
TACTTCTTCGACCGGCACTCGGAGGCCTTCGGCTTCATCCTGCTCTACGTGCGCGGCCAC
GGCAAGCTGCGCTTCGCGCCGCGGATGTGCGAGCTCTCCTTCTACAACGAGATGATCTAC
TGGGGCCTGGAGGGCGCGCACCTCGAGTACTGCTGCCAGCGCCGCCTCGACGACCGCATG
TCCGACACCTACACCTTCTACTCGGCCGACGAGCCGGGCGTGCTGGGCCGCGACGAGGCG
CGCCCCGGCGGGGCCGAGGCGGCTCCCTCCAGGCGCTGGCTGGAGCGCATGCGGCGGACC
TTCGAGGAGCCCACGTCGTCGCTGGCCGCGCAGATCCTGGCTAGCGTGTCGGTGGTGTTC
GTGATCGTGTCCATGGTGGTGCTGTGCGCCAGCACGTTGCCCGACTGGCGCAACGCAGCC
GCCGACAACCGCAGCCTGGATGACCGGAGCAGGTACTCCGCCGGCCCTGGGAGGGAGCCC
TCCGGGATAATTGAAGCTATCTGCATAGGTTGGTTCACTGCCGAGTGCATCGTGAGGTTC
ATTGTCTCCAAAAACAAGTGTGAGTTTGTCAAGAGACCCCTGAACATCATTGATTTACTG
GCAATCACGCCGTATTACATCTCTGTGTTGATGACAGTGTTTACAGGCGAGAACTCTCAA
CTCCAGAGGGCTGGAGTCACCTTGAGGGTACTTAGAATGATGAGGATTTTTTGGGTGATT
AAGCTTGCCCGTCACTTCATTGGTCTTCAGACACTCGGTTTGACTCTCAAACGTTGCTAC
CGAGAGATGGTTATGTTACTTGTCTTCATTTGTGTTGCCATGGCAATCTTTAGTGCACTT
TCTCAGCTTCTTGAACATGGGCTGGACCTGGAAACATCCAACAAGGACTTTACCAGCATT
CCTGCTGCCTGCTGGTGGGTGATTATCTCTATGACTACAGTTGGCTATGGAGATATGTAT
CCTATCACAGTGCCTGGAAGAATTCTTGGAGGAGTTTGTGTTGTCAGTGGAATTGTTCTA
TTGGCATTACCTATCACTTTTATCTACCATAGCTTTGTGCAGTGTTATCATGAGCTCAAG
TTTAGATCTGCTAGGTATAGTAGGAGCCTCTCCACTGAATTCCTGAATTAA
Chromosome Location
2
Locus
2p21
External Identifiers
ResourceLink
UniProtKB IDQ8TAE7
UniProtKB Entry NameKCNG3_HUMAN
HGNC IDHGNC:18306
General References
  1. Sano Y, Mochizuki S, Miyake A, Kitada C, Inamura K, Yokoi H, Nozawa K, Matsushime H, Furuichi K: Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. FEBS Lett. 2002 Feb 13;512(1-3):230-4. [Article]
  2. Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ: Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7986-91. [Article]
  3. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Mederos Y Schnitzler M, Rinne S, Skrobek L, Renigunta V, Schlichthorl G, Derst C, Gudermann T, Daut J, Preisig-Muller R: Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. J Biol Chem. 2009 Feb 13;284(7):4695-704. doi: 10.1074/jbc.M808786200. Epub 2008 Dec 11. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00228Enfluraneapproved, investigational, vet_approvedunknowninhibitoractivatorDetails
DB01069Promethazineapproved, investigationalunknowninducerDetails
DB01110Miconazoleapproved, investigational, vet_approvedunknowninhibitorDetails