Potassium voltage-gated channel subfamily G member 3
Details
- Name
- Potassium voltage-gated channel subfamily G member 3
- Synonyms
- Voltage-gated potassium channel subunit Kv10.1
- Voltage-gated potassium channel subunit Kv6.3
- Gene Name
- KCNG3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052237|Potassium voltage-gated channel subfamily G member 3 MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNE YFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRM SDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVF VIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRF IVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVI KLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSI PAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELK FRSARYSRSLSTEFLN
- Number of residues
- 436
- Molecular Weight
- 49592.025
- Theoretical pI
- Not Available
- GO Classification
- Functionsdelayed rectifier potassium channel activity / voltage-gated potassium channel activityProcessespotassium ion transmembrane transport / protein homooligomerization / regulation of ion transmembrane transportComponentsendoplasmic reticulum / integral component of membrane / plasma membrane / voltage-gated potassium channel complex
- General Function
- Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135).
- Specific Function
- Delayed rectifier potassium channel activity
- Pfam Domain Function
- Transmembrane Regions
- 169-190 221-242 254-274 285-305 321-342 388-416
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052238|Potassium voltage-gated channel subfamily G member 3 (KCNG3) ATGACCTTCGGGCGCAGCGGGGCGGCCTCGGTGGTGCTGAACGTGGGCGGCGCCCGGTAT TCGCTGTCCCGGGAGCTGCTGAAGGACTTCCCGCTGCGCCGCGTGAGCCGGCTGCACGGC TGCCGCTCCGAGCGCGACGTGCTCGAGGTGTGCGACGACTACGACCGCGAGCGCAACGAG TACTTCTTCGACCGGCACTCGGAGGCCTTCGGCTTCATCCTGCTCTACGTGCGCGGCCAC GGCAAGCTGCGCTTCGCGCCGCGGATGTGCGAGCTCTCCTTCTACAACGAGATGATCTAC TGGGGCCTGGAGGGCGCGCACCTCGAGTACTGCTGCCAGCGCCGCCTCGACGACCGCATG TCCGACACCTACACCTTCTACTCGGCCGACGAGCCGGGCGTGCTGGGCCGCGACGAGGCG CGCCCCGGCGGGGCCGAGGCGGCTCCCTCCAGGCGCTGGCTGGAGCGCATGCGGCGGACC TTCGAGGAGCCCACGTCGTCGCTGGCCGCGCAGATCCTGGCTAGCGTGTCGGTGGTGTTC GTGATCGTGTCCATGGTGGTGCTGTGCGCCAGCACGTTGCCCGACTGGCGCAACGCAGCC GCCGACAACCGCAGCCTGGATGACCGGAGCAGGTACTCCGCCGGCCCTGGGAGGGAGCCC TCCGGGATAATTGAAGCTATCTGCATAGGTTGGTTCACTGCCGAGTGCATCGTGAGGTTC ATTGTCTCCAAAAACAAGTGTGAGTTTGTCAAGAGACCCCTGAACATCATTGATTTACTG GCAATCACGCCGTATTACATCTCTGTGTTGATGACAGTGTTTACAGGCGAGAACTCTCAA CTCCAGAGGGCTGGAGTCACCTTGAGGGTACTTAGAATGATGAGGATTTTTTGGGTGATT AAGCTTGCCCGTCACTTCATTGGTCTTCAGACACTCGGTTTGACTCTCAAACGTTGCTAC CGAGAGATGGTTATGTTACTTGTCTTCATTTGTGTTGCCATGGCAATCTTTAGTGCACTT TCTCAGCTTCTTGAACATGGGCTGGACCTGGAAACATCCAACAAGGACTTTACCAGCATT CCTGCTGCCTGCTGGTGGGTGATTATCTCTATGACTACAGTTGGCTATGGAGATATGTAT CCTATCACAGTGCCTGGAAGAATTCTTGGAGGAGTTTGTGTTGTCAGTGGAATTGTTCTA TTGGCATTACCTATCACTTTTATCTACCATAGCTTTGTGCAGTGTTATCATGAGCTCAAG TTTAGATCTGCTAGGTATAGTAGGAGCCTCTCCACTGAATTCCTGAATTAA
- Chromosome Location
- 2
- Locus
- 2p21
- External Identifiers
Resource Link UniProtKB ID Q8TAE7 UniProtKB Entry Name KCNG3_HUMAN HGNC ID HGNC:18306 - General References
- Sano Y, Mochizuki S, Miyake A, Kitada C, Inamura K, Yokoi H, Nozawa K, Matsushime H, Furuichi K: Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. FEBS Lett. 2002 Feb 13;512(1-3):230-4. [Article]
- Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ: Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7986-91. [Article]
- Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Mederos Y Schnitzler M, Rinne S, Skrobek L, Renigunta V, Schlichthorl G, Derst C, Gudermann T, Daut J, Preisig-Muller R: Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. J Biol Chem. 2009 Feb 13;284(7):4695-704. doi: 10.1074/jbc.M808786200. Epub 2008 Dec 11. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00228 Enflurane approved, investigational, vet_approved unknown inhibitoractivator Details DB01069 Promethazine approved, investigational unknown inducer Details DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details