Potassium voltage-gated channel subfamily G member 4
Details
- Name
- Potassium voltage-gated channel subfamily G member 4
- Synonyms
- KCNG3
- Voltage-gated potassium channel subunit Kv6.4
- Gene Name
- KCNG4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052245|Potassium voltage-gated channel subfamily G member 4 MPMPSRDGGLHPRHHHYGSHSPWSQLLSSPMETPSIKGLYYRRVRKVGALDASPVDLKKE ILINVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAF GVIVSFLAAGKLVLLQEMCALSFQEELAYWGIEEAHLERCCLRKLLRKLEELEELAKLHR EDVLRQQRETRRPASHSSRWGLCMNRLREMVENPQSGLPGKVFACLSILFVATTAVSLCV STMPDLRAEEDQGECSRKCYYIFIVETICVAWFSLEFCLRFVQAQDKCQFFQGPLNIIDI LAISPYYVSLAVSEEPPEDGERPSGSSYLEKVGLVLRVLRALRILYVMRLARHSLGLQTL GLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKESGRVLEFTSIPASYWWAIISMTTVG YGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFSHSYLELKKEQEQLQARLRHLQN TGPASECELLDPHVASEHELMNDVNDLILEGPALPIMHM
- Number of residues
- 519
- Molecular Weight
- 58978.79
- Theoretical pI
- Not Available
- GO Classification
- Functionsdelayed rectifier potassium channel activity / ion channel binding / voltage-gated potassium channel activityProcessespotassium ion transmembrane transport / protein homooligomerization / regulation of ion transmembrane transportComponentsintegral component of membrane / plasma membrane / voltage-gated potassium channel complex
- General Function
- Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135).
- Specific Function
- Delayed rectifier potassium channel activity
- Pfam Domain Function
- Transmembrane Regions
- 219-240 262-283 295-314 329-353 369-390 433-461
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052246|Potassium voltage-gated channel subfamily G member 4 (KCNG4) ATGCCCATGCCTTCCAGAGACGGGGGCCTGCATCCCAGACACCACCACTATGGTTCCCAC AGCCCTTGGAGTCAGCTCCTGTCCAGCCCCATGGAGACGCCGTCCATCAAGGGCCTTTAC TACCGGAGGGTGCGGAAGGTGGGTGCCCTGGACGCCTCCCCAGTGGACCTGAAGAAGGAG ATCCTGATCAACGTGGGGGGCAGGAGGTATCTCCTCCCCTGGAGCACACTGGACCGGTTC CCGCTGAGCCGCCTGAGCAAACTCAGGCTCTGTCGGAGCTACGAGGAGATCGTGCAGCTC TGCGATGATTACGACGAGGACAGCCAGGAGTTCTTCTTCGACAGGAGCCCCAGCGCCTTC GGGGTGATCGTGAGCTTCCTGGCGGCCGGGAAGCTGGTGCTTCTGCAGGAGATGTGCGCG CTGTCCTTCCAGGAGGAGCTGGCCTACTGGGGCATCGAGGAGGCCCACCTGGAGAGGTGC TGCCTGCGGAAGCTGCTGAGGAAGCTGGAGGAGCTGGAGGAGCTGGCCAAGCTGCACAGG GAGGACGTACTGAGGCAGCAGAGGGAGACCCGCCGCCCCGCCTCGCACTCCTCGCGCTGG GGCCTGTGCATGAACCGGCTGCGCGAGATGGTGGAAAACCCGCAGTCCGGGCTGCCCGGG AAGGTCTTCGCTTGCCTCTCCATCCTCTTCGTGGCCACCACAGCCGTCAGCCTGTGTGTC AGCACCATGCCCGACCTCAGGGCAGAGGAGGACCAGGGCGAATGCTCTCGGAAGTGCTAC TATATTTTCATCGTGGAGACCATCTGCGTGGCCTGGTTCTCCCTGGAGTTCTGCCTGCGG TTTGTCCAGGCCCAAGACAAGTGTCAGTTCTTCCAGGGGCCCCTGAACATCATCGACATC CTGGCCATCTCCCCATACTACGTGTCGCTGGCGGTGTCTGAGGAGCCCCCGGAGGACGGC GAGAGGCCGAGCGGGAGCTCCTACCTGGAGAAGGTGGGGCTGGTCCTGCGTGTGCTGCGA GCGCTGCGCATCCTCTACGTGATGCGCCTGGCTCGCCACTCGCTGGGGCTGCAGACGCTG GGGCTCACCGTGCGCCGTTGCACACGTGAGTTCGGCCTGCTCCTTCTCTTCCTGGCCGTG GCCATCACCCTCTTCTCCCCTTTGGTCTACGTGGCCGAGAAGGAGTCCGGGCGGGTGCTG GAGTTCACCAGCATCCCCGCCTCCTATTGGTGGGCCATCATCTCCATGACAACGGTGGGC TACGGGGACATGGTGCCCCGCAGTGTGCCAGGCCAGATGGTGGCCCTCAGCAGCATCCTG AGCGGGATCCTCATCATGGCCTTCCCGGCCACGTCTATCTTCCACACCTTCTCCCACTCC TACCTGGAGCTCAAGAAGGAGCAGGAGCAGCTTCAGGCCCGCCTCCGCCACCTCCAAAAC ACCGGTCCAGCCAGTGAATGTGAACTCCTGGACCCCCATGTGGCCAGTGAACATGAGCTC ATGAACGATGTCAATGACCTAATCCTGGAGGGCCCAGCCTTGCCTATCATGCACATGTAA
- Chromosome Location
- 16
- Locus
- 16q24.1
- External Identifiers
Resource Link UniProtKB ID Q8TDN1 UniProtKB Entry Name KCNG4_HUMAN HGNC ID HGNC:19697 - General References
- Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ: Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7986-91. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Mederos Y Schnitzler M, Rinne S, Skrobek L, Renigunta V, Schlichthorl G, Derst C, Gudermann T, Daut J, Preisig-Muller R: Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. J Biol Chem. 2009 Feb 13;284(7):4695-704. doi: 10.1074/jbc.M808786200. Epub 2008 Dec 11. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00228 Enflurane approved, investigational, vet_approved unknown inhibitoractivator Details DB01069 Promethazine approved, investigational unknown inducer Details DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details