Scavenger receptor class B member 1

Details

Name
Scavenger receptor class B member 1
Synonyms
  • CD36 and LIMPII analogous 1
  • CD36 antigen-like 1
  • CD36L1
  • CLA-1
  • CLA1
  • Collagen type I receptor, thrombospondin receptor-like 1
  • SR-BI
  • SRB1
Gene Name
SCARB1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000377|Scavenger receptor class B member 1
MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIP
IPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQ
FQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIM
WGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGL
SKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYR
FVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTG
LHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESG
AMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSH
SLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLE
GLGPSLGGGTGS
Number of residues
552
Molecular Weight
60877.385
Theoretical pI
8.31
GO Classification
Functions
1-phosphatidylinositol binding / apolipoprotein A-I binding / apolipoprotein binding / high-density lipoprotein particle receptor activity / lipopolysaccharide binding / lipopolysaccharide receptor activity / low-density lipoprotein particle binding / phosphatidylserine binding / transporter activity / virus receptor activity
Processes
adhesion of symbiont to host / cell adhesion / cholesterol efflux / cholesterol homeostasis / cholesterol import / detection of lipopolysaccharide / high-density lipoprotein particle clearance / high-density lipoprotein particle remodeling / lipopolysaccharide transport / lipopolysaccharide-mediated signaling pathway / lipoprotein metabolic process / low-density lipoprotein particle clearance / phospholipid transport / positive regulation of cholesterol storage / positive regulation of endothelial cell migration / positive regulation of nitric-oxide synthase activity / positive regulation of triglyceride biosynthetic process / receptor-mediated endocytosis / recognition of apoptotic cell / regulation of phagocytosis / regulation of phosphatidylcholine catabolic process / reverse cholesterol transport / small molecule metabolic process / triglyceride homeostasis / vitamin transmembrane transport / wound healing
Components
caveola / cell surface / endocytic vesicle membrane / extracellular exosome / integral component of membrane / intracellular membrane-bounded organelle / lysosomal membrane / plasma membrane
General Function
Virus receptor activity
Specific Function
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity).(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes.
Pfam Domain Function
Transmembrane Regions
12-32 444-464
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0009993|Scavenger receptor class B member 1 (SCARB1)
ATGGGCTGCTCCGCCAAAGCGCGCTGGGCTGCCGGGGCGCTGGGCGTCGCGGGGCTACTG
TGCGCTGTGCTGGGCGCTGTCATGATCGTGATGGTGCCGTCGCTCATCAAGCAGCAGGTC
CTTAAGAACGTGCGCATCGACCCCAGTAGCCTGTCCTTCAACATGTGGAAGGAGATCCCT
ATCCCCTTCTATCTCTCCGTCTACTTCTTTGACGTCATGAACCCCAGCGAGATCCTGAAG
GGCGAGAAGCCGCAGGTGCGGGAGCGCGGGCCCTACGTGTACAGGGAGTTCAGGCACAAA
AGCAACATCACCTTCAACAACAACGACACCGTGTCCTTCCTCGAGTACCGCACCTTCCAG
TTCCAGCCCTCCAAGTCCCACGGCTCGGAGAGCGACTACATCGTCATGCCCAACATCCTG
GTCTTGGGTGCGGCGGTGATGATGGAGAATAAGCCCATGACCCTGAAGCTCATCATGACC
TTGGCATTCACCACCCTCGGCGAACGTGCCTTCATGAACCGCACTGTGGGTGAGATCATG
TGGGGCTACAAGGACCCCCTTGTGAATCTCATCAACAAGTACTTTCCAGGCATGTTCCCC
TTCAAGGACAAGTTCGGATTATTTGCTGAGCTCAACAACTCCGACTCTGGGCTCTTCACG
GTGTTCACGGGGGTCCAGAACATCAGCAGGATCCACCTCGTGGACAAGTGGAACGGGCTG
AGCAAGGTTGACTTCTGGCATTCCGATCAGTGCAACATGATCAATGGAACTTCTGGGCAA
ATGTGGCCGCCCTTCATGACTCCTGAGTCCTCGCTGGAGTTCTACAGCCCGGAGGCCTGC
CGATCCATGAAGCTAATGTACAAGGAGTCAGGGGTGTTTGAAGGCATCCCCACCTATCGC
TTCGTGGCTCCCAAAACCCTGTTTGCCAACGGGTCCATCTACCCACCCAACGAAGGCTTC
TGCCCGTGCCTGGAGTCTGGAATTCAGAACGTCAGCACCTGCAGGTTCAGTGCCCCCTTG
TTTCTCTCCCATCCTCACTTCCTCAACGCTGACCCGGTTCTGGCAGAAGCGGTGACTGGC
CTGCACCCTAACCAGGAGGCACACTCCTTGTTCCTGGACATCCACCCGGTCACGGGAATC
CCCATGAACTGCTCTGTGAAACTGCAGCTGAGCCTCTACATGAAATCTGTCGCAGGCATT
GGACAAACTGGGAAGATTGAGCCTGTGGTCCTGCCGCTGCTCTGGTTTGCAGAGAGCGGG
GCCATGGAGGGGGAGACTCTTCACACATTCTACACTCAGCTGGTGTTGATGCCCAAGGTG
ATGCACTATGCCCAGTACGTCCTCCTGGCGCTGGGCTGCGTCCTGCTGCTGGTCCCTGTC
ATCTGCCAAATCCGGAGCCAAGGTCCTGAGGACACCGTGAGCCAGCCAGGCCTGGCCGCT
GGGCCTGACCGGCCCCCCAGCCCCTACACCCCGCTTCTCCCGGACTCTCCCAGCGGACAG
CCCCCCAGCCCCACAGCCTGA
Chromosome Location
12
Locus
12q24.31
External Identifiers
ResourceLink
UniProtKB IDQ8WTV0
UniProtKB Entry NameSCRB1_HUMAN
GenBank Protein ID397607
GenBank Gene IDZ22555
GenAtlas IDSCARB1
HGNC IDHGNC:1664
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00144Phosphatidyl serineinvestigational, nutraceuticalunknownDetails
DB11251Tocopherolapproved, investigationalnotransporterDetails
DB14003alpha-Tocopherol acetateapprovednosubstrateDetails
DB11635TocofersolanapprovednosubstrateDetails
DB00163Vitamin Eapproved, nutraceutical, vet_approvedunknownsubstrateDetails